Simultaneous Separation of Actinium and Radium Isotopes from a Proton Irradiated Thorium Matrix
Abstract
A new method has been developed for the isolation of 223,224,225Ra, in high yield and purity, from a proton irradiated 232Th matrix. Herein we report an all-aqueous process using multiple solid-supported adsorption steps including a citrate chelation method developed to remove >99.9% of the barium contaminants by activity from the final radium product. A procedure involving the use of three columns in succession was developed, and the separation of 223,224,225Ra from the thorium matrix was obtained with an overall recovery yield of 91 ± 3%, average radiochemical purity of 99.9%, and production yields that correspond to physical yields based on previously measured excitation functions.
- Authors:
-
- Los Alamos National Lab. (LANL), Los Alamos, NM (United States)
- Los Alamos National Lab. (LANL), Los Alamos, NM (United States). Chemistry Division
- Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)
- Publication Date:
- Research Org.:
- Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)
- Sponsoring Org.:
- USDOE Office of Science (SC), Nuclear Physics (NP)
- OSTI Identifier:
- 1396129
- Alternate Identifier(s):
- OSTI ID: 1491311
- Report Number(s):
- LA-UR-17-23916
Journal ID: ISSN 2045-2322
- Grant/Contract Number:
- AC52-06NA25396; AC05-00OR22725
- Resource Type:
- Accepted Manuscript
- Journal Name:
- Scientific Reports
- Additional Journal Information:
- Journal Volume: 7; Journal Issue: 1; Journal ID: ISSN 2045-2322
- Publisher:
- Nature Publishing Group
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY; 73 NUCLEAR PHYSICS AND RADIATION PHYSICS; experimental nuclear physics; nuclear chemistry
Citation Formats
Mastren, Tara, Radchenko, Valery, Owens, Allison, Copping, Roy, Boll, Rose Ann, Griswold, Justin R., Mirzadeh, Saed, Wyant, Lance E., Brugh, Mark, Engle, Jonathan W., Nortier, Francois M., Birnbaum, Eva R., John, Kevin D., and Fassbender, Michael E. Simultaneous Separation of Actinium and Radium Isotopes from a Proton Irradiated Thorium Matrix. United States: N. p., 2017.
Web. doi:10.1038/s41598-017-08506-9.
Mastren, Tara, Radchenko, Valery, Owens, Allison, Copping, Roy, Boll, Rose Ann, Griswold, Justin R., Mirzadeh, Saed, Wyant, Lance E., Brugh, Mark, Engle, Jonathan W., Nortier, Francois M., Birnbaum, Eva R., John, Kevin D., & Fassbender, Michael E. Simultaneous Separation of Actinium and Radium Isotopes from a Proton Irradiated Thorium Matrix. United States. doi:10.1038/s41598-017-08506-9.
Mastren, Tara, Radchenko, Valery, Owens, Allison, Copping, Roy, Boll, Rose Ann, Griswold, Justin R., Mirzadeh, Saed, Wyant, Lance E., Brugh, Mark, Engle, Jonathan W., Nortier, Francois M., Birnbaum, Eva R., John, Kevin D., and Fassbender, Michael E. Tue .
"Simultaneous Separation of Actinium and Radium Isotopes from a Proton Irradiated Thorium Matrix". United States. doi:10.1038/s41598-017-08506-9. https://www.osti.gov/servlets/purl/1396129.
@article{osti_1396129,
title = {Simultaneous Separation of Actinium and Radium Isotopes from a Proton Irradiated Thorium Matrix},
author = {Mastren, Tara and Radchenko, Valery and Owens, Allison and Copping, Roy and Boll, Rose Ann and Griswold, Justin R. and Mirzadeh, Saed and Wyant, Lance E. and Brugh, Mark and Engle, Jonathan W. and Nortier, Francois M. and Birnbaum, Eva R. and John, Kevin D. and Fassbender, Michael E.},
abstractNote = {A new method has been developed for the isolation of 223,224,225Ra, in high yield and purity, from a proton irradiated 232Th matrix. Herein we report an all-aqueous process using multiple solid-supported adsorption steps including a citrate chelation method developed to remove >99.9% of the barium contaminants by activity from the final radium product. A procedure involving the use of three columns in succession was developed, and the separation of 223,224,225Ra from the thorium matrix was obtained with an overall recovery yield of 91 ± 3%, average radiochemical purity of 99.9%, and production yields that correspond to physical yields based on previously measured excitation functions.},
doi = {10.1038/s41598-017-08506-9},
journal = {Scientific Reports},
number = 1,
volume = 7,
place = {United States},
year = {2017},
month = {8}
}
Web of Science
Figures / Tables:

Works referenced in this record:
Selenium-72 formation via natBr(p,x) induced by 100MeV Protons: Steps towards a novel 72Se/72As generator system
journal, April 2012
- Ballard, B.; Wycoff, D.; Birnbaum, E. R.
- Applied Radiation and Isotopes, Vol. 70, Issue 4
Pretargeted radioimmunotherapy in tumored mice using an in vivo 212Pb/212Bi generator
journal, October 2005
- Su, Fu-Min; Beaumier, Paul; Axworthy, Don
- Nuclear Medicine and Biology, Vol. 32, Issue 7
Ac, La, and Ce radioimpurities in 225Ac produced in 40–200 MeV proton irradiations of thorium
journal, January 2014
- Engle, Jonathan W.; Weidner, John W.; Ballard, Beau D.
- Radiochimica Acta, Vol. 102, Issue 7
Separation of Radium and Barium by Ion Exchange Elution
journal, June 1959
- Power, W. H.; Kirby, H. W.; McCluggage, W. C.
- Analytical Chemistry, Vol. 31, Issue 6
Separation of Th, U, Pa, Ra and Ac from natural uranium and thorium series
journal, November 1999
- Alhassanieh, O.; Abdul-Hadi, A.; Ghafar, M.
- Applied Radiation and Isotopes, Vol. 51, Issue 5
Recovery of Ra-223 from natural thorium irradiated by protons
journal, January 2016
- Vasiliev, Aleksandr N.; Ostapenko, Valentina S.; Lapshina, Elena V.
- Radiochimica Acta, Vol. 104, Issue 8
Production of actinium-225 for alpha particle mediated radioimmunotherapy
journal, May 2005
- Boll, Rose A.; Malkemus, Dairin; Mirzadeh, Saed
- Applied Radiation and Isotopes, Vol. 62, Issue 5
Extraction generator of 223Ra for nuclear medicine
journal, August 2011
- Shishkin, D. N.; Krupitskii, S. V.; Kuznetsov, S. A.
- Radiochemistry, Vol. 53, Issue 4
Preparation of 225Ac by 226Ra(γ, n) photonuclear reaction on an electron accelerator, MT-25 microtron
journal, March 2006
- Maslov, O. D.; Sabel’nikov, A. V.; Dmitriev, S. N.
- Radiochemistry, Vol. 48, Issue 2
Evaluation of potential chelating agents for radium
journal, May 2002
- Henriksen, Gjermund; Hoff, Per; Larsen, Roy H.
- Applied Radiation and Isotopes, Vol. 56, Issue 5
Radium-223: From Radiochemical Development to Clinical Applications in Targeted Cancer Therapy
journal, September 2008
- Bruland, Oyvind; Jonasdottir, Thora; Fisher, Darrell
- Current Radiopharmaceuticalse, Vol. 1, Issue 3
Sequential extraction procedure for determination of uranium, thorium, radium, lead and polonium radionuclides by alpha spectrometry in environmental samples
journal, January 2006
- Oliveira, J. M.; Carvalho, F. P.
- Czechoslovak Journal of Physics, Vol. 56, Issue 1
Formation cross-sections and chromatographic separation of protactinium isotopes formed in proton-irradiated thorium metal
journal, January 2016
- Radchenko, Valery; Engle, Jonathan W.; Wilson, Justin J.
- Radiochimica Acta, Vol. 104, Issue 5
Radium Ra 223 Dichloride Injection: U.S. Food and Drug Administration Drug Approval Summary
journal, November 2013
- Kluetz, P. G.; Pierce, W.; Maher, V. E.
- Clinical Cancer Research, Vol. 20, Issue 1
Separation of radium, thorium, uranium and plutonium on OSTION anion exchanger in atmospheric precipitation samples
journal, April 1988
- Burčík, I.
- Journal of Radioanalytical and Nuclear Chemistry Articles, Vol. 121, Issue 2
Preparation of 227Ac/223Ra by neutron irradiation of 226Ra
journal, August 2014
- Kukleva, Ekaterina; Kozempel, Ján; Vlk, Martin
- Journal of Radioanalytical and Nuclear Chemistry, Vol. 304, Issue 1
Complexes of Alkaline Earth Cations Including Radium with Amino Acids and Related Compounds
journal, July 1954
- Schubert, Jack
- Journal of the American Chemical Society, Vol. 76, Issue 13
Enhanced -odd, -odd electromagnetic moments in reflection asymmetric nuclei
journal, September 1997
- Spevak, V.; Auerbach, N.; Flambaum, V. V.
- Physical Review C, Vol. 56, Issue 3
Cross sections from proton irradiation of thorium at 800 MeV
journal, July 2013
- Engle, Jonathan W.; Mashnik, Stepan G.; Weidner, John W.
- Physical Review C, Vol. 88, Issue 1
Large scale accelerator production of 225Ac: Effective cross sections for 78–192 MeV protons incident on 232Th targets
journal, December 2016
- Griswold, J. R.; Medvedev, D. G.; Engle, J. W.
- Applied Radiation and Isotopes, Vol. 118
Functionalized NaA nanozeolites labeled with 224,225Ra for targeted alpha therapy
journal, October 2013
- Piotrowska, Agata; Leszczuk, Edyta; Bruchertseifer, Frank
- Journal of Nanoparticle Research, Vol. 15, Issue 11
Separation of Radium from Barium by the Use of an Ion-exchange Column Procedure 1
journal, October 1948
- Tompkins, Edward R.
- Journal of the American Chemical Society, Vol. 70, Issue 10
Proton-induced cross sections relevant to production of 225Ac and 223Ra in natural thorium targets below 200MeV
journal, November 2012
- Weidner, J. W.; Mashnik, S. G.; John, K. D.
- Applied Radiation and Isotopes, Vol. 70, Issue 11
223Ra for endoradiotherapeutic applications prepared from an immobilized 227Ac/227Th source
journal, January 2001
- Henriksen, Gjermund; Hoff, P.; Alstad, J.
- Radiochimica Acta, Vol. 89, Issue 10
Biomedical radioisotope generator systems
journal, March 1996
- Mirzadeh, S.; Knapp, F. F.
- Journal of Radioanalytical and Nuclear Chemistry Articles, Vol. 203, Issue 2
Application of ion exchange and extraction chromatography to the separation of actinium from proton-irradiated thorium metal for analytical purposes
journal, February 2015
- Radchenko, V.; Engle, J. W.; Wilson, J. J.
- Journal of Chromatography A, Vol. 1380, p. 55-63
A Radium-223 microgenerator from cyclotron-produced trace Actinium-227
journal, January 2017
- Abou, Diane S.; Pickett, Juile; Mattson, John E.
- Applied Radiation and Isotopes, Vol. 119
First Measurement of the Atomic Electric Dipole Moment of
journal, June 2015
- Parker, R. H.; Dietrich, M. R.; Kalita, M. R.
- Physical Review Letters, Vol. 114, Issue 23
Fissionability of nuclides in the thorium region at excitation energies to 100 MeV
journal, November 1979
- Hogan, J. J.; Gadioli, E.; Gadioli-Erba, E.
- Physical Review C, Vol. 20, Issue 5
Works referencing / citing this record:
Microfluidics-based separation of actinium-225 from radium-225 for medical applications
journal, May 2019
- Davern, Sandra; O’Neil, David; Hallikainen, Hannah
- Separation Science and Technology, Vol. 54, Issue 12
Microfluidics-based separation of actinium-225 from radium-225 for medical applications
journal, May 2019
- Davern, Sandra; O’Neil, David; Hallikainen, Hannah
- Separation Science and Technology, Vol. 54, Issue 12
The coordination chemistry of Cm III , Am III , and Ac III in nitrate solutions: an actinide L 3 -edge EXAFS study
journal, January 2018
- Ferrier, Maryline G.; Stein, Benjamin W.; Bone, Sharon E.
- Chemical Science, Vol. 9, Issue 35
Isotope harvesting at FRIB: additional opportunities for scientific discovery
journal, August 2019
- Abel, E. Paige; Avilov, Mikael; Ayres, Virginia
- Journal of Physics G: Nuclear and Particle Physics, Vol. 46, Issue 10
Observation of internal-conversion electrons emitted from produced by β decay of
journal, October 2019
- Shigekawa, Y.; Kasamatsu, Y.; Watanabe, E.
- Physical Review C, Vol. 100, Issue 4
Selective biosorption of thorium (IV) from aqueous solutions by ginkgo leaf
journal, March 2018
- Huang, Yaoyao; Hu, Yang; Chen, Lvcun
- PLOS ONE, Vol. 13, Issue 3
Optimization of Cation Exchange for the Separation of Actinium-225 from Radioactive Thorium, Radium-223 and Other Metals
journal, May 2019
- Fitzsimmons, Jonathan; Foley, Bryan; Torre, Bryna
- Molecules, Vol. 24, Issue 10
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