Simultaneous Separation of Actinium and Radium Isotopes from a Proton Irradiated Thorium Matrix

Mastren, Tara; Radchenko, Valery; Owens, Allison; Copping, Roy; Boll, Rose Ann; Griswold, Justin R.; Mirzadeh, Saed; Wyant, Lance E.; Brugh, Mark; Engle, Jonathan W.; Nortier, Francois M.; Birnbaum, Eva R.; John, Kevin D.; Fassbender, Michael E.

doi:10.1038/s41598-017-08506-9

Title: Simultaneous Separation of Actinium and Radium Isotopes from a Proton Irradiated Thorium Matrix

Journal Article · Tue Aug 15 00:00:00 UTC 2017 · Scientific Reports

DOI: https://doi.org/10.1038/s41598-017-08506-9 · OSTI ID:1396129

^[1]; Radchenko, Valery ^[2];

^[3];

^[3]; Wyant, Lance E. ^[3]; Brugh, Mark ^[2]; Engle, Jonathan W. ^[2]; Nortier, Francois M. ^[2]; Birnbaum, Eva R. ^[2]; John, Kevin D. ^[2]; Fassbender, Michael E. ^[2]

Los Alamos National Lab. (LANL), Los Alamos, NM (United States)
Los Alamos National Lab. (LANL), Los Alamos, NM (United States). Chemistry Division
Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)

A new method has been developed for the isolation of ^223,224,225Ra, in high yield and purity, from a proton irradiated ²³²Th matrix. We report an all-aqueous process using multiple solid-supported adsorption steps including a citrate chelation method developed to remove >99.9% of the barium contaminants by activity from the final radium product. Moreover, we developed a procedure involving the use of three columns in succession, and the separation of ^223,224,225Ra from the thorium matrix was obtained with an overall recovery yield of 91 ± 3%, average radiochemical purity of 99.9%, and production yields that correspond to physical yields based on previously measured excitation functions.

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Research Organization:: Los Alamos National Laboratory (LANL), Los Alamos, NM (United States); Oak Ridge National Laboratory (ORNL), Oak Ridge, TN (United States)

Sponsoring Organization:: USDOE; USDOE Office of Science (SC), Nuclear Physics (NP) (SC-26)

Grant/Contract Number:: AC05-00OR22725; AC52-06NA25396

OSTI ID:: 1396129

Report Number(s):: LA-UR--17-23916

Journal Information:: Scientific Reports, Journal Name: Scientific Reports Journal Issue: 1 Vol. 7; ISSN 2045-2322

Publisher:: Nature Publishing GroupCopyright Statement

Country of Publication:: United States

Language:: English

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An Overview of Targeted Alpha Therapy with ²²⁵ Actinium and ²¹³ Bismuth Morgenstern, Alfred; Apostolidis, Christos; Kratochwil, Clemens Current Radiopharmaceuticals, Vol. 11, Issue 3 https://doi.org/10.2174/1874471011666180502104524	journal	October 2018
The coordination chemistry of Cm ^III , Am ^III , and Ac ^III in nitrate solutions: an actinide L ₃ -edge EXAFS study Ferrier, Maryline G.; Stein, Benjamin W.; Bone, Sharon E. Chemical Science, Vol. 9, Issue 35 https://doi.org/10.1039/c8sc02270d	journal	January 2018
Microfluidics-based separation of actinium-225 from radium-225 for medical applications Davern, Sandra; O’Neil, David; Hallikainen, Hannah Separation Science and Technology, Vol. 54, Issue 12 https://doi.org/10.1080/01496395.2019.1614956	journal	May 2019
Isotope harvesting at FRIB: additional opportunities for scientific discovery Abel, E. Paige; Avilov, Mikael; Ayres, Virginia Journal of Physics G: Nuclear and Particle Physics, Vol. 46, Issue 10 https://doi.org/10.1088/1361-6471/ab26cc	journal	August 2019
Observation of internal-conversion electrons emitted from Th 229 m produced by β decay of Ac 229 Shigekawa, Y.; Kasamatsu, Y.; Watanabe, E. Physical Review C, Vol. 100, Issue 4 https://doi.org/10.1103/physrevc.100.044304	journal	October 2019
Selective biosorption of thorium (IV) from aqueous solutions by ginkgo leaf Huang, Yaoyao; Hu, Yang; Chen, Lvcun PLOS ONE, Vol. 13, Issue 3 https://doi.org/10.1371/journal.pone.0193659	journal	March 2018
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