skip to main content

DOE PAGESDOE PAGES

Title: Mechanisms Underlying CD4+ Treg Immune Regulation in the Adult: From Experiments to Models

To maintain immunological balance the organism has to be tolerant to self while remaining competent to mount an effective immune response against third-party antigens. An important mechanism of this immune regulation involves the action of regulatory T-cell (Tregs). In this mini-review, we discuss some of the known and proposed mechanisms by which Tregs exert their influence in the context of immune regulation, and the contribution of mathematical modeling for these mechanistic studies. These models explore the mechanisms of action of regulatory T cells, and include hypotheses of multiple signals, delivered through simultaneous antigen-presenting cell (APC) conjugation; interaction of feedback loops between APC, Tregs, and effector cells; or production of specific cytokines that act on effector cells. As the field matures, and competing models are winnowed out, it is likely that we will be able to quantify how tolerance-inducing strategies, such as CD4-blockade, affect T-cell dynamics and what mechanisms explain the observed behavior of T-cell based tolerance.
Authors:
 [1] ;  [1] ;  [2]
  1. Inst. Gulbenkian de Ciência, Oeira (Portugal); Univ. of Lisbon (Portugal)
  2. Los Alamos National Lab. (LANL), Los Alamos, NM (United States)
Publication Date:
Report Number(s):
LA-UR-13-27742
Journal ID: ISSN 1664-3224
Grant/Contract Number:
AC52-06NA25396
Type:
Accepted Manuscript
Journal Name:
Frontiers in Immunology
Additional Journal Information:
Journal Volume: 4; Journal ID: ISSN 1664-3224
Publisher:
Frontiers Research Foundation
Research Org:
Los Alamos National Lab. (LANL), Los Alamos, NM (United States)
Sponsoring Org:
Work for Others (WFO); USDOE
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; Biological Science
OSTI Identifier:
1396112

Caridade, Marta, Graca, Luis, and Ribeiro, Ruy M. Mechanisms Underlying CD4+ Treg Immune Regulation in the Adult: From Experiments to Models. United States: N. p., Web. doi:10.3389/fimmu.2013.00378.
Caridade, Marta, Graca, Luis, & Ribeiro, Ruy M. Mechanisms Underlying CD4+ Treg Immune Regulation in the Adult: From Experiments to Models. United States. doi:10.3389/fimmu.2013.00378.
Caridade, Marta, Graca, Luis, and Ribeiro, Ruy M. 2013. "Mechanisms Underlying CD4+ Treg Immune Regulation in the Adult: From Experiments to Models". United States. doi:10.3389/fimmu.2013.00378. https://www.osti.gov/servlets/purl/1396112.
@article{osti_1396112,
title = {Mechanisms Underlying CD4+ Treg Immune Regulation in the Adult: From Experiments to Models},
author = {Caridade, Marta and Graca, Luis and Ribeiro, Ruy M.},
abstractNote = {To maintain immunological balance the organism has to be tolerant to self while remaining competent to mount an effective immune response against third-party antigens. An important mechanism of this immune regulation involves the action of regulatory T-cell (Tregs). In this mini-review, we discuss some of the known and proposed mechanisms by which Tregs exert their influence in the context of immune regulation, and the contribution of mathematical modeling for these mechanistic studies. These models explore the mechanisms of action of regulatory T cells, and include hypotheses of multiple signals, delivered through simultaneous antigen-presenting cell (APC) conjugation; interaction of feedback loops between APC, Tregs, and effector cells; or production of specific cytokines that act on effector cells. As the field matures, and competing models are winnowed out, it is likely that we will be able to quantify how tolerance-inducing strategies, such as CD4-blockade, affect T-cell dynamics and what mechanisms explain the observed behavior of T-cell based tolerance.},
doi = {10.3389/fimmu.2013.00378},
journal = {Frontiers in Immunology},
number = ,
volume = 4,
place = {United States},
year = {2013},
month = {11}
}