A Theoretical Lower Bound for Selection on the Expression Levels of Proteins
Abstract
We use simple models of the costs and benefits of microbial gene expression to show that changing a protein's expression away from its optimum by 2-fold should reduce fitness by at least [Formula: see text], where P is the fraction the cell's protein that the gene accounts for. As microbial genes are usually expressed at above 5 parts per million, and effective population sizes are likely to be above 10(6), this implies that 2-fold changes to gene expression levels are under strong selection, as [Formula: see text], where Ne is the effective population size and s is the selection coefficient. Thus, most gene duplications should be selected against. On the other hand, we predict that for most genes, small changes in the expression will be effectively neutral.
- Authors:
-
- Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States). Environmental Genomics and Systems Biology
- Publication Date:
- Research Org.:
- Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)
- Sponsoring Org.:
- USDOE Office of Science (SC), Biological and Environmental Research (BER)
- OSTI Identifier:
- 1379417
- Grant/Contract Number:
- AC02-05CH11231
- Resource Type:
- Accepted Manuscript
- Journal Name:
- Genome Biology and Evolution
- Additional Journal Information:
- Journal Volume: 8; Journal Issue: 6; Journal ID: ISSN 1759-6653
- Publisher:
- Society for Molecular Biology and Evolution
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 59 BASIC BIOLOGICAL SCIENCES; 60 APPLIED LIFE SCIENCES; gene expression levels; metabolic models; microbiology
Citation Formats
Price, Morgan N., and Arkin, Adam P. A Theoretical Lower Bound for Selection on the Expression Levels of Proteins. United States: N. p., 2016.
Web. doi:10.1093/gbe/evw126.
Price, Morgan N., & Arkin, Adam P. A Theoretical Lower Bound for Selection on the Expression Levels of Proteins. United States. https://doi.org/10.1093/gbe/evw126
Price, Morgan N., and Arkin, Adam P. Sat .
"A Theoretical Lower Bound for Selection on the Expression Levels of Proteins". United States. https://doi.org/10.1093/gbe/evw126. https://www.osti.gov/servlets/purl/1379417.
@article{osti_1379417,
title = {A Theoretical Lower Bound for Selection on the Expression Levels of Proteins},
author = {Price, Morgan N. and Arkin, Adam P.},
abstractNote = {We use simple models of the costs and benefits of microbial gene expression to show that changing a protein's expression away from its optimum by 2-fold should reduce fitness by at least [Formula: see text], where P is the fraction the cell's protein that the gene accounts for. As microbial genes are usually expressed at above 5 parts per million, and effective population sizes are likely to be above 10(6), this implies that 2-fold changes to gene expression levels are under strong selection, as [Formula: see text], where Ne is the effective population size and s is the selection coefficient. Thus, most gene duplications should be selected against. On the other hand, we predict that for most genes, small changes in the expression will be effectively neutral.},
doi = {10.1093/gbe/evw126},
journal = {Genome Biology and Evolution},
number = 6,
volume = 8,
place = {United States},
year = {Sat Jun 11 00:00:00 EDT 2016},
month = {Sat Jun 11 00:00:00 EDT 2016}
}
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