New insight into the role of MMP14 in metabolic balance
Abstract
Membrane-anchored matrix metalloproteinase 14 (MMP14) is involved broadly in organ development through both its proteolytic and signal-transducing functions. Knockout of Mmp14 (KO) in mice results in a dramatic reduction of body size and wasting followed by premature death, the mechanism of which is poorly understood. Since the mammary gland develops after birth and is thus dependent for its functional progression on systemic and local cues, we chose it as an organ model for understanding why KO mice fail to thrive. A global analysis of the mammary glands’ proteome in the wild type (WT) and KO mice provided insight into an unexpected role of MMP14 in maintaining metabolism and homeostasis. We performed mass spectrometry and quantitative proteomics to determine the protein signatures of mammary glands from 7 to 11 days old WT and KO mice and found that KO rudiments had a significantly higher level of rate-limiting enzymes involved in catabolic pathways. Glycogen and lipid levels in KO rudiments were reduced, and the circulating levels of triglycerides and glucose were lower. Analysis of the ultrastructure of mammary glands imaged by electron microscopy revealed a significant increase in autophagy signatures in KO mice. Finally, Mmp14 silenced mammary epithelial cells displayed enhanced autophagy.more »
- Authors:
-
- Univ. of California, Davis, CA (United States); Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)
- Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Univ. of Calcutta, Calcutta (India)
- Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Univ. de Sao Paulo, Sao Paulo (Brazil)
- Columbia Univ. Medical Center, New York, NY (United States)
- Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)
- Kanazawa Univ., Kanazawa (Japan)
- Univ. of California, Davis, CA (United States)
- Publication Date:
- Research Org.:
- Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)
- Sponsoring Org.:
- USDOE Office of Science (SC), Biological and Environmental Research (BER)
- OSTI Identifier:
- 1378994
- Grant/Contract Number:
- AC02-05CH11231
- Resource Type:
- Accepted Manuscript
- Journal Name:
- PeerJ
- Additional Journal Information:
- Journal Volume: 4; Journal Issue: 7; Journal ID: ISSN 2167-8359
- Publisher:
- PeerJ Inc.
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 59 BASIC BIOLOGICAL SCIENCES
Citation Formats
Mori, Hidetoshi, Bhat, Ramray, Bruni-Cardoso, Alexandre, Chen, Emily I., Jorgens, Danielle M., Coutinho, Kester, Louie, Katherine, Bowen, Benjamin Ben, Inman, Jamie L., Tecca, Victoria, Lee, Sarah J., Becker-Weimann, Sabine, Northen, Trent, Seiki, Motoharu, Borowsky, Alexander D., Auer, Manfred, and Bissell, Mina J. New insight into the role of MMP14 in metabolic balance. United States: N. p., 2016.
Web. doi:10.7717/peerj.2142.
Mori, Hidetoshi, Bhat, Ramray, Bruni-Cardoso, Alexandre, Chen, Emily I., Jorgens, Danielle M., Coutinho, Kester, Louie, Katherine, Bowen, Benjamin Ben, Inman, Jamie L., Tecca, Victoria, Lee, Sarah J., Becker-Weimann, Sabine, Northen, Trent, Seiki, Motoharu, Borowsky, Alexander D., Auer, Manfred, & Bissell, Mina J. New insight into the role of MMP14 in metabolic balance. United States. https://doi.org/10.7717/peerj.2142
Mori, Hidetoshi, Bhat, Ramray, Bruni-Cardoso, Alexandre, Chen, Emily I., Jorgens, Danielle M., Coutinho, Kester, Louie, Katherine, Bowen, Benjamin Ben, Inman, Jamie L., Tecca, Victoria, Lee, Sarah J., Becker-Weimann, Sabine, Northen, Trent, Seiki, Motoharu, Borowsky, Alexander D., Auer, Manfred, and Bissell, Mina J. Wed .
"New insight into the role of MMP14 in metabolic balance". United States. https://doi.org/10.7717/peerj.2142. https://www.osti.gov/servlets/purl/1378994.
@article{osti_1378994,
title = {New insight into the role of MMP14 in metabolic balance},
author = {Mori, Hidetoshi and Bhat, Ramray and Bruni-Cardoso, Alexandre and Chen, Emily I. and Jorgens, Danielle M. and Coutinho, Kester and Louie, Katherine and Bowen, Benjamin Ben and Inman, Jamie L. and Tecca, Victoria and Lee, Sarah J. and Becker-Weimann, Sabine and Northen, Trent and Seiki, Motoharu and Borowsky, Alexander D. and Auer, Manfred and Bissell, Mina J.},
abstractNote = {Membrane-anchored matrix metalloproteinase 14 (MMP14) is involved broadly in organ development through both its proteolytic and signal-transducing functions. Knockout of Mmp14 (KO) in mice results in a dramatic reduction of body size and wasting followed by premature death, the mechanism of which is poorly understood. Since the mammary gland develops after birth and is thus dependent for its functional progression on systemic and local cues, we chose it as an organ model for understanding why KO mice fail to thrive. A global analysis of the mammary glands’ proteome in the wild type (WT) and KO mice provided insight into an unexpected role of MMP14 in maintaining metabolism and homeostasis. We performed mass spectrometry and quantitative proteomics to determine the protein signatures of mammary glands from 7 to 11 days old WT and KO mice and found that KO rudiments had a significantly higher level of rate-limiting enzymes involved in catabolic pathways. Glycogen and lipid levels in KO rudiments were reduced, and the circulating levels of triglycerides and glucose were lower. Analysis of the ultrastructure of mammary glands imaged by electron microscopy revealed a significant increase in autophagy signatures in KO mice. Finally, Mmp14 silenced mammary epithelial cells displayed enhanced autophagy. Applied to a systemic level, these findings indicate that MMP14 is a crucial regulator of tissue homeostasis. If operative on a systemic level, these findings could explain how Mmp14KO litter fail to thrive due to disorder in metabolism.},
doi = {10.7717/peerj.2142},
journal = {PeerJ},
number = 7,
volume = 4,
place = {United States},
year = {Wed Jul 13 00:00:00 EDT 2016},
month = {Wed Jul 13 00:00:00 EDT 2016}
}
Web of Science
Works referenced in this record:
Autophagy in the Cellular Energetic Balance
journal, May 2011
- Singh, Rajat; Cuervo, Ana Maria
- Cell Metabolism, Vol. 13, Issue 5
Laser Scanning–Based Tissue Autofluorescence/Fluorescence Imaging (LS-TAFI), a New Technique for Analysis of Microanatomy in Whole-Mount Tissues
journal, June 2012
- Mori, Hidetoshi; Borowsky, Alexander D.; Bhat, Ramray
- The American Journal of Pathology, Vol. 180, Issue 6
Necrosis Induction in Glioblastoma Cells Reveals a New “Bioswitch” Function for the MT1-MMP/G6PT Signaling Axis in proMMP-2 Activation versus Cell Death Decision
journal, April 2007
- Belkaid, Anissa; Fortier, Simon; Cao, Jian
- Neoplasia, Vol. 9, Issue 4
Quantitative Proteomics Using 15N SILAC Mouse
journal, July 2013
- Koller, Antonius; Wen, Ruofeng; Wu, Xiao
- Journal of Proteomics And Genomics Research, Vol. 1, Issue 2
Target-decoy search strategy for increased confidence in large-scale protein identifications by mass spectrometry
journal, February 2007
- Elias, Joshua E.; Gygi, Steven P.
- Nature Methods, Vol. 4, Issue 3
Cellular activation of proMMP-13 by MT1-MMP depends on the C-terminal domain of MMP-13
journal, November 2002
- Knäuper, Vera; Bailey, Louise; Worley, Joanna R.
- FEBS Letters, Vol. 532, Issue 1-2
A targeted mutation at the known collagenase cleavage site in mouse type I collagen impairs tissue remodeling
journal, July 1995
- Liu, X.
- The Journal of Cell Biology, Vol. 130, Issue 1
A quantitative analysis software tool for mass spectrometry–based proteomics
journal, March 2008
- Park, Sung Kyu; Venable, John D.; Xu, Tao
- Nature Methods, Vol. 5, Issue 4
Cytoplasmic tail of MT1-MMP regulates macrophage motility independently from its protease activity
journal, May 2009
- Sakamoto, Takeharu; Seiki, Motoharu
- Genes to Cells, Vol. 14, Issue 5
Membrane-type 1 matrix metalloproteinase and cell migration
journal, September 2003
- Seiki, Motoharu; Mori, Hidetoshi; Kajita, Masahiro
- Biochemical Society Symposia, Vol. 70
A proteomic approach to identify substrates of matrix metalloproteinase-14 in human plasma
journal, October 2004
- Hwang, In Kwan; Park, Sung Min; Kim, Se Yeon
- Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, Vol. 1702, Issue 1
A Pericellular Collagenase Directs the 3-Dimensional Development of White Adipose Tissue
journal, May 2006
- Chun, Tae-Hwa; Hotary, Kevin B.; Sabeh, Farideh
- Cell, Vol. 125, Issue 3
An Alternative Processing of Integrin α v Subunit in Tumor Cells by Membrane Type-1 Matrix Metalloproteinase
journal, December 2001
- Ratnikov, Boris I.; Rozanov, Dmitri V.; Postnova, Tanya I.
- Journal of Biological Chemistry, Vol. 277, Issue 9
Changes in fat cell morphology during lactation in the mouse
journal, December 1973
- Elias, Joel J.; Pitelka, Dorothy R.; Armstrong, Rosa C.
- The Anatomical Record, Vol. 177, Issue 4
Freeze substitution in 3 hours or less: FREEZE SUBSTIUTION IN 3 HOURS OR LESS
journal, August 2011
- McDONALD, K. L.; Webb, R. I.
- Journal of Microscopy, Vol. 243, Issue 3
CD44 directs membrane-type 1 matrix metalloproteinase to lamellipodia by associating with its hemopexin-like domain
journal, August 2002
- Mori, H.
- The EMBO Journal, Vol. 21, Issue 15
Pro-MMP-9 activation by the MT1-MMP/MMP-2 axis and MMP-3: role of TIMP-2 and plasma membranes
journal, August 2003
- Toth, Marta; Chvyrkova, Irina; Bernardo, M. Margarida
- Biochemical and Biophysical Research Communications, Vol. 308, Issue 2
Strategies for MMP inhibition in cancer: innovations for the post-trial era
journal, September 2002
- Overall, Christopher Mark; López-Otín, Carlos
- Nature Reviews Cancer, Vol. 2, Issue 9
Glycolytic defects in muscle: Aspects of collaboration between basic science and clinical medicine
journal, January 1995
- Tarui, Seiichiro
- Muscle & Nerve, Vol. 18, Issue S14
Collective epithelial cell invasion overcomes mechanical barriers of collagenous extracellular matrix by a narrow tube-like geometry and MMP14-dependent local softening
journal, January 2011
- Alcaraz, Jordi; Mori, Hidetoshi; Ghajar, Cyrus M.
- Integrative Biology, Vol. 3, Issue 12
Glycolytic defects in muscle: Aspects of collaboration between basic science and clinical medicine
journal, January 1995
- Tarui, Seiichiro
- Muscle & Nerve, Vol. 18, Issue S14
Self-organization of engineered epithelial tubules by differential cellular motility
journal, August 2009
- Mori, H.; Gjorevski, N.; Inman, J. L.
- Proceedings of the National Academy of Sciences, Vol. 106, Issue 35
Collective epithelial cell invasion overcomes mechanical barriers of collagenous extracellular matrix by a narrow tube-like geometry and MMP14-dependent local softening
journal, January 2011
- Alcaraz, Jordi; Mori, Hidetoshi; Ghajar, Cyrus M.
- Integrative Biology, Vol. 3, Issue 12
Carnitine palmitoyltransferases 1 and 2: biochemical, molecular and medical aspects
journal, December 2004
- Bonnefont, J.
- Molecular Aspects of Medicine, Vol. 25, Issue 5-6
Strategies for MMP inhibition in cancer: innovations for the post-trial era
journal, September 2002
- Overall, Christopher Mark; López-Otín, Carlos
- Nature Reviews Cancer, Vol. 2, Issue 9
Crosstalk between neovessels and mural cells directs the site-specific expression of MT1-MMP to endothelial tip cells
journal, April 2007
- Yana, I.; Sagara, H.; Takaki, S.
- Journal of Cell Science, Vol. 120, Issue 9
Crosstalk between neovessels and mural cells directs the site-specific expression of MT1-MMP to endothelial tip cells
journal, April 2007
- Yana, I.; Sagara, H.; Takaki, S.
- Journal of Cell Science, Vol. 120, Issue 9
Selective high-affinity transport of aspartate by a Drosophila homologue of the excitatory amino-acid transporters
journal, February 2000
- Besson, Marie-Thérèse; Soustelle, Laurent; Birman, Serge
- Current Biology, Vol. 10, Issue 4
Cytoplasmic lipid droplet accumulation in developing mammary epithelial cells: roles of adipophilin and lipid metabolism
journal, April 2007
- Russell, Tanya D.; Palmer, Carol A.; Orlicky, David J.
- Journal of Lipid Research, Vol. 48, Issue 7
Sexually Dimorphic Diet-Induced Insulin Resistance in Obese Tissue Inhibitor of Metalloproteinase-2 (TIMP-2)-Deficient Mice
journal, April 2011
- Jaworski, Diane M.; Sideleva, Olga; Stradecki, Holly M.
- Endocrinology, Vol. 152, Issue 4
Genetic Link Between Obesity and MMP14-Dependent Adipogenic Collagen Turnover
journal, July 2010
- Chun, T. -H.; Inoue, M.; Morisaki, H.
- Diabetes, Vol. 59, Issue 10
The hemopexin domain of MMP3 is responsible for mammary epithelial invasion and morphogenesis through extracellular interaction with HSP90
journal, April 2013
- Correia, A. L.; Mori, H.; Chen, E. I.
- Genes & Development, Vol. 27, Issue 7
Method to Correlate Tandem Mass Spectra of Modified Peptides to Amino Acid Sequences in the Protein Database
journal, April 1995
- Yates, John R.; Eng, Jimmy K.; McCormack, Ashley L.
- Analytical Chemistry, Vol. 67, Issue 8
Cryoimmobilization and three-dimensional visualization of C. elegans ultrastructure
journal, October 2003
- Muller-Reichert, T.; Hohenberg, H.; O'Toole, E. T.
- Journal of Microscopy, Vol. 212, Issue 1
The Low Density Lipoprotein Receptor-related Protein LRP Is Regulated by Membrane Type-1 Matrix Metalloproteinase (MT1-MMP) Proteolysis in Malignant Cells
journal, November 2003
- Rozanov, Dmitri V.; Hahn-Dantona, Elizabeth; Strickland, Dudley K.
- Journal of Biological Chemistry, Vol. 279, Issue 6
Mass spectrometry imaging for in situ kinetic histochemistry
journal, April 2013
- Louie, Katherine B.; Bowen, Benjamin P.; McAlhany, Stephanie
- Scientific Reports, Vol. 3, Issue 1
Changes in fat cell morphology during lactation in the mouse
journal, December 1973
- Elias, Joel J.; Pitelka, Dorothy R.; Armstrong, Rosa C.
- The Anatomical Record, Vol. 177, Issue 4
Identification of a mutation in liver glycogen phosphorylase in glycogen storage disease type VI
journal, May 1998
- Chang, S.
- Human Molecular Genetics, Vol. 7, Issue 5
Transmembrane/cytoplasmic, rather than catalytic, domains of Mmp14 signal to MAPK activation and mammary branching morphogenesis via binding to integrin 1
journal, December 2012
- Mori, H.; Lo, A. T.; Inman, J. L.
- Development, Vol. 140, Issue 2
MT1-MMP-Dependent Control of Skeletal Stem Cell Commitment via a β1-Integrin/YAP/TAZ Signaling Axis
journal, May 2013
- Tang, Yi; Rowe, R. Grant; Botvinick, Elliot L.
- Developmental Cell, Vol. 25, Issue 4
SnapShot: Branching Morphogenesis
journal, August 2014
- Chuong, Cheng-Ming; Bhat, Ramray; Widelitz, Randall B.
- Cell, Vol. 158, Issue 5
Changes in mammary fat pad composition and lipolytic capacity throughout pregnancy
journal, November 2005
- Pujol, Esperanza; Proenza, Ana M.; Roca, Pilar
- Cell and Tissue Research, Vol. 323, Issue 3
A Pericellular Collagenase Directs the 3-Dimensional Development of White Adipose Tissue
journal, May 2006
- Chun, Tae-Hwa; Hotary, Kevin B.; Sabeh, Farideh
- Cell, Vol. 125, Issue 3
Fatal infantile form of muscle phosphofructokinase deficiency
journal, November 1986
- Servidei, S.; Bonilla, E.; Diedrich, R. G.
- Neurology, Vol. 36, Issue 11
?-enolase deficiency, a new metabolic myopathy of distal glycolysis
journal, January 2001
- Comi, Giacomo P.; Fortunato, Francesco; Lucchiari, Sabrina
- Annals of Neurology, Vol. 50, Issue 2
A matrix metalloproteinase expressed on the surface of invasive tumour cells
journal, July 1994
- Sato, Hiroshi; Takino, Takahisa; Okada, Yasunori
- Nature, Vol. 370, Issue 6484
Distribution and source of lipoprotein lipase in mouse mammary gland
journal, May 1991
- Jensen, Dr; Bessesen, Dh; Etienne, J.
- Journal of Lipid Research, Vol. 32, Issue 5
Metabolic regulation in the lactating mammary gland: a lipid synthesizing machine
journal, February 2007
- Rudolph, Michael C.; McManaman, James L.; Phang, TzuLip
- Physiological Genomics, Vol. 28, Issue 3
Molecular Mechanisms of Hepatic Steatosis and Insulin Resistance in the AGPAT2-Deficient Mouse Model of Congenital Generalized Lipodystrophy
journal, February 2009
- Cortés, Víctor A.; Curtis, David E.; Sukumaran, Suja
- Cell Metabolism, Vol. 9, Issue 2
Autophagy in the Cellular Energetic Balance
journal, May 2011
- Singh, Rajat; Cuervo, Ana Maria
- Cell Metabolism, Vol. 13, Issue 5
Target-decoy search strategy for increased confidence in large-scale protein identifications by mass spectrometry
journal, February 2007
- Elias, Joshua E.; Gygi, Steven P.
- Nature Methods, Vol. 4, Issue 3
A quantitative analysis software tool for mass spectrometry–based proteomics
journal, March 2008
- Park, Sung Kyu; Venable, John D.; Xu, Tao
- Nature Methods, Vol. 5, Issue 4
Laser Scanning–Based Tissue Autofluorescence/Fluorescence Imaging (LS-TAFI), a New Technique for Analysis of Microanatomy in Whole-Mount Tissues
journal, June 2012
- Mori, Hidetoshi; Borowsky, Alexander D.; Bhat, Ramray
- The American Journal of Pathology, Vol. 180, Issue 6
Necrosis Induction in Glioblastoma Cells Reveals a New “Bioswitch” Function for the MT1-MMP/G6PT Signaling Axis in proMMP-2 Activation versus Cell Death Decision
journal, April 2007
- Belkaid, Anissa; Fortier, Simon; Cao, Jian
- Neoplasia, Vol. 9, Issue 4
CD44 directs membrane-type 1 matrix metalloproteinase to lamellipodia by associating with its hemopexin-like domain
journal, August 2002
- Mori, H.
- The EMBO Journal, Vol. 21, Issue 15
SnapShot: Branching Morphogenesis
journal, August 2014
- Chuong, Cheng-Ming; Bhat, Ramray; Widelitz, Randall B.
- Cell, Vol. 158, Issue 5
[39] Bandeiraea simplicifolia lectin II
book, January 1978
- Ebisu, Shigeyuki; Goldstein, Irwin J.
- Methods in Enzymology
Cytoplasmic tail of MT1-MMP regulates macrophage motility independently from its protease activity
journal, May 2009
- Sakamoto, Takeharu; Seiki, Motoharu
- Genes to Cells, Vol. 14, Issue 5
Effect of diet on exercise tolerance in carnitine palmitoyltransferase II deficiency
journal, August 2003
- Orngreen, M. C.; Ejstrup, R.; Vissing, J.
- Neurology, Vol. 61, Issue 4
Metabolic cooperativity between epithelial cells and adipocytes of mice
journal, November 1981
- Bartley, J. C.; Emerman, J. T.; Bissell, M. J.
- American Journal of Physiology-Cell Physiology, Vol. 241, Issue 5
MT1-MMP promotes vascular smooth muscle dedifferentiation through LRP1 processing
journal, December 2008
- Lehti, K.; Rose, N. F.; Valavaara, S.
- Journal of Cell Science, Vol. 122, Issue 1
Matrix Metalloproteinases in Remodeling of the Normal and Neoplastic Mammary Gland
journal, January 1998
- Rudolph-Owen, Laura A.; Matrisian, Lynn M.
- Journal of Mammary Gland Biology and Neoplasia, Vol. 3, Issue 2, p. 177-189
A Rapid Method of Total Lipid Extraction and Purification
journal, January 1959
- Bligh, E. G.; Dyer, W. J.
- Canadian Journal of Biochemistry and Physiology, Vol. 37, Issue 1
AGPAT2 is mutated in congenital generalized lipodystrophy linked to chromosome 9q34
journal, April 2002
- Agarwal, Anil K.; Arioglu, Elif; de Almeida, Salome
- Nature Genetics, Vol. 31, Issue 1
A matrix metalloproteinase expressed on the surface of invasive tumour cells
journal, July 1994
- Sato, Hiroshi; Takino, Takahisa; Okada, Yasunori
- Nature, Vol. 370, Issue 6484
Interrelationship of glycogen metabolism and lactose synthesis in mammary epithelial cells of mice
journal, November 1980
- Emerman, J. T.; Bartley, J. C.; Bissell, M. J.
- Biochemical Journal, Vol. 192, Issue 2
MT1-MMP-Dependent Control of Skeletal Stem Cell Commitment via a β1-Integrin/YAP/TAZ Signaling Axis
journal, May 2013
- Tang, Yi; Rowe, R. Grant; Botvinick, Elliot L.
- Developmental Cell, Vol. 25, Issue 4
Histochemical detection of glycogen usingGriffonia simplicifolia agglutinin II
journal, November 1986
- Hennigar, Randolph A.; Schulte, Bradley A.; Spicer, Samuel S.
- The Histochemical Journal, Vol. 18, Issue 11-12
A targeted mutation at the known collagenase cleavage site in mouse type I collagen impairs tissue remodeling
journal, July 1995
- Liu, X.
- The Journal of Cell Biology, Vol. 130, Issue 1
Autophagy and Metabolism
journal, December 2010
- Rabinowitz, J. D.; White, E.
- Science, Vol. 330, Issue 6009
Validating matrix metalloproteinases as drug targets and anti-targets for cancer therapy
journal, March 2006
- Overall, Christopher M.; Kleifeld, Oded
- Nature Reviews Cancer, Vol. 6, Issue 3
Targeting the Warburg Effect That Arises in Tumor Cells Expressing Membrane Type-1 Matrix Metalloproteinase
journal, March 2011
- Sakamoto, Takeharu; Niiya, Daigo; Seiki, Motoharu
- Journal of Biological Chemistry, Vol. 286, Issue 16
Self-organization of engineered epithelial tubules by differential cellular motility
journal, August 2009
- Mori, H.; Gjorevski, N.; Inman, J. L.
- Proceedings of the National Academy of Sciences, Vol. 106, Issue 35
An MT1-MMP-PDGF receptor- axis regulates mural cell investment of the microvasculature
journal, April 2005
- Lehti, K.
- Genes & Development, Vol. 19, Issue 8
Freeze substitution in 3 hours or less: FREEZE SUBSTIUTION IN 3 HOURS OR LESS
journal, August 2011
- McDONALD, K. L.; Webb, R. I.
- Journal of Microscopy, Vol. 243, Issue 3
Transmembrane/cytoplasmic, rather than catalytic, domains of Mmp14 signal to MAPK activation and mammary branching morphogenesis via binding to integrin 1
journal, December 2012
- Mori, H.; Lo, A. T.; Inman, J. L.
- Development, Vol. 140, Issue 2
Hnrpab regulates neural development and neuron cell survival after glutamate stimulation
journal, February 2012
- Sinnamon, J. R.; Waddell, C. B.; Nik, S.
- RNA, Vol. 18, Issue 4
DTASelect and Contrast: Tools for Assembling and Comparing Protein Identifications from Shotgun Proteomics
journal, February 2002
- Tabb, David L.; McDonald, W. Hayes; Yates, John R.
- Journal of Proteome Research, Vol. 1, Issue 1, p. 21-26
A role for the NAD-dependent deacetylase Sirt1 in the regulation of autophagy
journal, February 2008
- Lee, I. H.; Cao, L.; Mostoslavsky, R.
- Proceedings of the National Academy of Sciences, Vol. 105, Issue 9
An MT1-MMP-PDGF receptor- axis regulates mural cell investment of the microvasculature
journal, April 2005
- Lehti, K.
- Genes & Development, Vol. 19, Issue 8
?-enolase deficiency, a new metabolic myopathy of distal glycolysis
journal, January 2001
- Comi, Giacomo P.; Fortunato, Francesco; Lucchiari, Sabrina
- Annals of Neurology, Vol. 50, Issue 2
MT1-MMP promotes vascular smooth muscle dedifferentiation through LRP1 processing
journal, December 2008
- Lehti, K.; Rose, N. F.; Valavaara, S.
- Journal of Cell Science, Vol. 122, Issue 1
Identification of a mutation in liver glycogen phosphorylase in glycogen storage disease type VI
journal, May 1998
- Chang, S.
- Human Molecular Genetics, Vol. 7, Issue 5
Membrane-type 1 matrix metalloproteinase and cell migration
journal, September 2003
- Seiki, Motoharu; Mori, Hidetoshi; Kajita, Masahiro
- Biochemical Society Symposia, Vol. 70
A proteomic approach to identify substrates of matrix metalloproteinase-14 in human plasma
journal, October 2004
- Hwang, In Kwan; Park, Sung Min; Kim, Se Yeon
- Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, Vol. 1702, Issue 1
Genetic Link Between Obesity and MMP14-Dependent Adipogenic Collagen Turnover
journal, July 2010
- Chun, T. -H.; Inoue, M.; Morisaki, H.
- Diabetes, Vol. 59, Issue 10
MT1-MMP-Deficient Mice Develop Dwarfism, Osteopenia, Arthritis, and Connective Tissue Disease due to Inadequate Collagen Turnover
journal, October 1999
- Holmbeck, Kenn; Bianco, Paolo; Caterina, John
- Cell, Vol. 99, Issue 1
Mass spectrometry imaging for in situ kinetic histochemistry
journal, April 2013
- Louie, Katherine B.; Bowen, Benjamin P.; McAlhany, Stephanie
- Scientific Reports, Vol. 3, Issue 1
Validating matrix metalloproteinases as drug targets and anti-targets for cancer therapy
journal, March 2006
- Overall, Christopher M.; Kleifeld, Oded
- Nature Reviews Cancer, Vol. 6, Issue 3
The hemopexin domain of MMP3 is responsible for mammary epithelial invasion and morphogenesis through extracellular interaction with HSP90
journal, April 2013
- Correia, A. L.; Mori, H.; Chen, E. I.
- Genes & Development, Vol. 27, Issue 7
A Rapid Method of Total Lipid Extraction and Purification
journal, August 1959
- Bligh, E. G.; Dyer, W. J.
- Canadian Journal of Biochemistry and Physiology, Vol. 37, Issue 8
Efecto de la suplementación con grasas protegidas sobre parámetros productivos y reproductivos en vacas lactantes
journal, September 2013
- Duque Q., Mónica; Rosero N., Ricardo; Gallo, Jorge
- Revista MVZ Córdoba, Vol. 18, Issue 3
Sexually Dimorphic Diet-Induced Insulin Resistance in Obese Tissue Inhibitor of Metalloproteinase-2 (TIMP-2)-Deficient Mice
journal, April 2011
- Jaworski, Diane M.; Sideleva, Olga; Stradecki, Holly M.
- Endocrinology, Vol. 152, Issue 4
Works referencing / citing this record:
Pathobiology of the 129:Stat1 −/− mouse model of human age-related ER-positive breast cancer with an immune infiltrate-excluded phenotype
journal, September 2017
- Mori, Hidetoshi; Chen, Jane Q.; Cardiff, Robert D.
- Breast Cancer Research, Vol. 19, Issue 1
Pathobiology of the 129:Stat1 −/− mouse model of human age-related ER-positive breast cancer with an immune infiltrate-excluded phenotype
journal, September 2017
- Mori, Hidetoshi; Chen, Jane Q.; Cardiff, Robert D.
- Breast Cancer Research, Vol. 19, Issue 1
The Expanding Role of MT1-MMP in Cancer Progression
journal, May 2019
- Knapinska, Anna M.; Fields, Gregg B.
- Pharmaceuticals, Vol. 12, Issue 2
Dual functions of ARP101 in targeting membrane type-1 matrix metalloproteinase: Impact on U87 glioblastoma cell invasion and autophagy signaling
journal, October 2018
- Desjarlais, Michel; Annabi, Borhane
- Chemical Biology & Drug Design, Vol. 93, Issue 3
The Expanding Role of MT1-MMP in Cancer Progression
journal, May 2019
- Knapinska, Anna M.; Fields, Gregg B.
- Pharmaceuticals, Vol. 12, Issue 2
Beyond EGFR inhibition: multilateral combat strategies to stop the progression of head and neck cancer
journal, January 2019
- Byeon, Hyung Kwon; Ku, Minhee; Yang, Jaemoon
- Experimental & Molecular Medicine, Vol. 51, Issue 1
Beyond EGFR inhibition: multilateral combat strategies to stop the progression of head and neck cancer
journal, January 2019
- Byeon, Hyung Kwon; Ku, Minhee; Yang, Jaemoon
- Experimental & Molecular Medicine, Vol. 51, Issue 1