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Title: Synthetic Analogues of Nitrogenase Metallocofactors: Challenges and Developments

Abstract

Nitrogenase is the only known biological system capable of reducing N2 to NH3, which is a critical component of bioavailable nitrogen fixation. Since the discovery of discrete iron-sulfur metalloclusters within the nitrogenase MoFe protein, synthetic inorganic chemists have sought to reproduce the structural features of these clusters in order to understand how they facilitate the binding, activation and hydrogenation of N2. Through the decades following the initial identification of these clusters, significant progress has been made to synthetically replicate certain compositional and functional aspects of the biogenic clusters. Although much work remains to generate synthetic iron–sulfur clusters that can reduce N2 to NH3, the insights borne from past and recent developments are discussed in this concept article.

Authors:
 [1];  [1];  [1];  [1]
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  1. Univ. of California, Irvine, CA (United States)
Publication Date:
Research Org.:
Univ. of California, Irvine, CA (United States)
Sponsoring Org.:
USDOE Office of Science (SC)
OSTI Identifier:
1533142
Alternate Identifier(s):
OSTI ID: 1375467
Grant/Contract Number:  
SC0014470
Resource Type:
Accepted Manuscript
Journal Name:
Chemistry - A European Journal
Additional Journal Information:
Journal Volume: 23; Journal Issue: 51; Journal ID: ISSN 0947-6539
Publisher:
ChemPubSoc Europe
Country of Publication:
United States
Language:
English
Subject:
37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY; Chemistry

Citation Formats

Sickerman, Nathaniel S., Tanifuji, Kazuki, Hu, Yilin, and Ribbe, Markus W. Synthetic Analogues of Nitrogenase Metallocofactors: Challenges and Developments. United States: N. p., 2017. Web. doi:10.1002/chem.201702496.
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Sickerman, Nathaniel S., Tanifuji, Kazuki, Hu, Yilin, & Ribbe, Markus W. Synthetic Analogues of Nitrogenase Metallocofactors: Challenges and Developments. United States. https://doi.org/10.1002/chem.201702496
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Sickerman, Nathaniel S., Tanifuji, Kazuki, Hu, Yilin, and Ribbe, Markus W. Thu . "Synthetic Analogues of Nitrogenase Metallocofactors: Challenges and Developments". United States. https://doi.org/10.1002/chem.201702496. https://www.osti.gov/servlets/purl/1533142.
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@article{osti_1533142,
title = {Synthetic Analogues of Nitrogenase Metallocofactors: Challenges and Developments},
author = {Sickerman, Nathaniel S. and Tanifuji, Kazuki and Hu, Yilin and Ribbe, Markus W.},
abstractNote = {Nitrogenase is the only known biological system capable of reducing N2 to NH3, which is a critical component of bioavailable nitrogen fixation. Since the discovery of discrete iron-sulfur metalloclusters within the nitrogenase MoFe protein, synthetic inorganic chemists have sought to reproduce the structural features of these clusters in order to understand how they facilitate the binding, activation and hydrogenation of N2. Through the decades following the initial identification of these clusters, significant progress has been made to synthetically replicate certain compositional and functional aspects of the biogenic clusters. Although much work remains to generate synthetic iron–sulfur clusters that can reduce N2 to NH3, the insights borne from past and recent developments are discussed in this concept article.},
doi = {10.1002/chem.201702496},
journal = {Chemistry - A European Journal},
number = 51,
volume = 23,
place = {United States},
year = {Thu Jul 20 00:00:00 EDT 2017},
month = {Thu Jul 20 00:00:00 EDT 2017}
}
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Works referenced in this record:

Glyceride-Mimetic Prodrugs Incorporating Self-Immolative Spacers Promote Lymphatic Transport, Avoid First-Pass Metabolism, and Enhance Oral Bioavailability
journal, August 2016

  • Hu, Luojuan; Quach, Tim; Han, Sifei
  • Angewandte Chemie International Edition, Vol. 55, Issue 44
  • DOI: 10.1002/anie.201604207

The Preparation, Properties and Structure of the Iron Carbonyl Carbide Fe 5 (CO) 15 C
journal, December 1962

  • Braye, Emile H.; Dahl, Lawrence F.; Hubel, Walter.
  • Journal of the American Chemical Society, Vol. 84, Issue 24
  • DOI: 10.1021/ja00883a004

ATP-Independent Formation of Hydrocarbons Catalyzed by Isolated Nitrogenase Cofactors
journal, January 2012

  • Lee, Chi Chung; Hu, Yilin; Ribbe, Markus W.
  • Angewandte Chemie, Vol. 124, Issue 8
  • DOI: 10.1002/ange.201108916

Biomimetic assembly and activation of [FeFe]-hydrogenases
journal, June 2013

  • Berggren, G.; Adamska, A.; Lambertz, C.
  • Nature, Vol. 499, Issue 7456
  • DOI: 10.1038/nature12239

Uncoupling binding of substrate CO from turnover by vanadium nitrogenase
journal, October 2015

  • Lee, Chi Chung; Fay, Aaron W.; Weng, Tsu-Chien
  • Proceedings of the National Academy of Sciences, Vol. 112, Issue 45
  • DOI: 10.1073/pnas.1519696112

Insight into the Iron–Molybdenum Cofactor of Nitrogenase from Synthetic Iron Complexes with Sulfur, Carbon, and Hydride Ligands
journal, June 2016

  • Čorić, Ilija; Holland, Patrick L.
  • Journal of the American Chemical Society, Vol. 138, Issue 23
  • DOI: 10.1021/jacs.6b00747

DINITROGEN FIXATION CATALYZED BY THE REDUCED SPECIES OF [Fe 4 S 4 (SPh) 4 ] 2− AND [Mo 2 Fe 6 S 8 (SPh) 9 ] 3−
journal, August 1982

  • Tanaka, Koji; Hozumi, Yoshiyuki; Tanaka, Toshio
  • Chemistry Letters, Vol. 11, Issue 8
  • DOI: 10.1246/cl.1982.1203

Structural Basis of Biological Nitrogen Fixation
journal, January 1996

  • Howard, James B.; Rees, Douglas C.
  • Chemical Reviews, Vol. 96, Issue 7
  • DOI: 10.1021/cr9500545

Comparison of Iron-Molybdenum Cofactor-deficient Nitrogenase MoFe Proteins by X-ray Absorption Spectroscopy: IMPLICATIONS FOR P-CLUSTER BIOSYNTHESIS
journal, April 2004

  • Corbett, Mary C.; Hu, Yilin; Naderi, Farzad
  • Journal of Biological Chemistry, Vol. 279, Issue 27
  • DOI: 10.1074/jbc.M403156200

Synthesis of New [8Fe-7S] Clusters:  A Topological Link between the Core Structures of P-Cluster, FeMo-co, and FeFe-co of Nitrogenases
journal, August 2007

  • Ohki, Yasuhiro; Ikagawa, Yohei; Tatsumi, Kazuyuki
  • Journal of the American Chemical Society, Vol. 129, Issue 34
  • DOI: 10.1021/ja072256b

Mechanism of Nitrogen Fixation by Nitrogenase: The Next Stage
journal, January 2014

  • Hoffman, Brian M.; Lukoyanov, Dmitriy; Yang, Zhi-Yong
  • Chemical Reviews, Vol. 114, Issue 8
  • DOI: 10.1021/cr400641x

New Synthetic Routes to Metal-Sulfur Clusters Relevant to the Nitrogenase Metallo-Clusters
journal, May 2013

  • Ohki, Yasuhiro; Tatsumi, Kazuyuki
  • Zeitschrift für anorganische und allgemeine Chemie, Vol. 639, Issue 8-9
  • DOI: 10.1002/zaac.201300081

Crystallographic structure of the nitrogenase iron protein from Azotobacter vinelandii
journal, September 1992

Biosynthesis of Nitrogenase Metalloclusters
journal, December 2013

  • Ribbe, Markus W.; Hu, Yilin; Hodgson, Keith O.
  • Chemical Reviews, Vol. 114, Issue 8
  • DOI: 10.1021/cr400463x

Structure of Precursor-Bound NifEN: A Nitrogenase FeMo Cofactor Maturase/Insertase
journal, January 2011

NifS-Mediated Assembly of [4Fe−4S] Clusters in the N- and C-Terminal Domains of the NifU Scaffold Protein †
journal, October 2005

  • Smith, Archer D.; Jameson, Guy N. L.; Dos Santos, Patricia C.
  • Biochemistry, Vol. 44, Issue 39
  • DOI: 10.1021/bi051257i

Structural basis of biological nitrogen fixation
journal, April 2005

  • Rees, Douglas C.; Akif Tezcan, F.; Haynes, Chad A.
  • Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences, Vol. 363, Issue 1829
  • DOI: 10.1098/rsta.2004.1539

Relevance of oxygen ligands to reduction of ligating dinitrogen
journal, January 1976

  • Chatt, Joseph; Pearman, Alan J.; Richards, Raymond L.
  • Nature, Vol. 259, Issue 5540
  • DOI: 10.1038/259204a0

Differential Reduction of CO 2 by Molybdenum and Vanadium Nitrogenases
journal, September 2014

  • Rebelein, Johannes G.; Hu, Yilin; Ribbe, Markus W.
  • Angewandte Chemie International Edition, Vol. 53, Issue 43
  • DOI: 10.1002/anie.201406863

Ligand binding to the FeMo-cofactor: Structures of CO-bound and reactivated nitrogenase
journal, September 2014

Fe-N2/CO complexes that model a possible role for the interstitial C atom of FeMo-cofactor (FeMoco)
journal, September 2013

  • Rittle, J.; Peters, J. C.
  • Proceedings of the National Academy of Sciences, Vol. 110, Issue 40
  • DOI: 10.1073/pnas.1310153110

Reduction of C 1 Substrates to Hydrocarbons by the Homometallic Precursor and Synthetic Mimic of the Nitrogenase Cofactor
journal, January 2017

  • Sickerman, Nathaniel S.; Tanifuji, Kazuki; Lee, Chi Chung
  • Journal of the American Chemical Society, Vol. 139, Issue 2
  • DOI: 10.1021/jacs.6b11633

Identification and characterization of functional homologs of nitrogenase cofactor biosynthesis protein NifB from methanogens
journal, November 2015

  • Fay, Aaron W.; Wiig, Jared A.; Lee, Chi Chung
  • Proceedings of the National Academy of Sciences, Vol. 112, Issue 48
  • DOI: 10.1073/pnas.1510409112

Synthesis and Structural Characterization of the New Mo2Fe6S8(PR3)6(Cl4-cat)2 Clusters. Double Cubanes Containing Two Edge-Linked [MoFe3S4]2+ Reduced Cores
journal, July 1995

  • Demadis, Konstantinos D.; Campana, Charles F.; Coucouvanis, Dimitri
  • Journal of the American Chemical Society, Vol. 117, Issue 29
  • DOI: 10.1021/ja00134a039

Nitrogenase reactivity with P-cluster variants
journal, September 2005

  • Hu, Y.; Corbett, M. C.; Fay, A. W.
  • Proceedings of the National Academy of Sciences, Vol. 102, Issue 39
  • DOI: 10.1073/pnas.0506967102

The Clusters of Nitrogenase:  Synthetic Methodology in the Construction of Weak-Field Clusters
journal, February 2004

  • Lee, Sonny C.; Holm, R. H.
  • Chemical Reviews, Vol. 104, Issue 2
  • DOI: 10.1021/cr0206216

Spontaneous activation of [FeFe]-hydrogenases by an inorganic [2Fe] active site mimic
journal, August 2013

  • Esselborn, Julian; Lambertz, Camilla; Adamska-Venkatesh, Agnieszka
  • Nature Chemical Biology, Vol. 9, Issue 10
  • DOI: 10.1038/nchembio.1311

Bacterial Alternative Nitrogen Fixation Systems
journal, January 1988

  • Joerger, Rolf D.; Bishop, Paul E.; Evans, Harold J.
  • CRC Critical Reviews in Microbiology, Vol. 16, Issue 1
  • DOI: 10.3109/10408418809104465

Differential Reduction of CO 2 by Molybdenum and Vanadium Nitrogenases
journal, September 2014

  • Rebelein, Johannes G.; Hu, Yilin; Ribbe, Markus W.
  • Angewandte Chemie, Vol. 126, Issue 43
  • DOI: 10.1002/ange.201406863

Synthesis and crystallographic characterization of bis(tetramethylammonium) carbidohexadecacarbonylhexaferrate, a hexanuclear carbidocarbonyl derivative of iron
journal, June 1971

  • Churchill, Melvyn R.; Wormald, John; Knight, John
  • Journal of the American Chemical Society, Vol. 93, Issue 12
  • DOI: 10.1021/ja00741a058

Structure and Reactivity of an Asymmetric Synthetic Mimic of Nitrogenase Cofactor
journal, November 2016

  • Tanifuji, Kazuki; Sickerman, Nathaniel; Lee, Chi Chung
  • Angewandte Chemie, Vol. 128, Issue 50
  • DOI: 10.1002/ange.201608806

Catalytic and stoichiometric multielectron reduction of hydrazine to ammonia and acetylene to ethylene with clusters that contain the MFe3S4 cores (MMo, V). Relevance to the function of nitrogenase
journal, May 1996

  • Coucouvanis, Dimitri; Demadis, Konstantinos D.; Malinak, Steven M.
  • Journal of Molecular Catalysis A: Chemical, Vol. 107, Issue 1-3
  • DOI: 10.1016/1381-1169(95)00168-9

The catalytic reduction of hydrazine to ammonia by the MoFe3S4 cubanes and implications regarding the function of nitrogenase. Evidence for direct involvement of the molybdenum atom in substrate reduction
journal, December 1993

  • Coucouvanis, Dimitri; Mosier, Patrick E.; Demadis, Konstantinos D.
  • Journal of the American Chemical Society, Vol. 115, Issue 25
  • DOI: 10.1021/ja00078a079

Combining a Nitrogenase Scaffold and a Synthetic Compound into an Artificial Enzyme
journal, October 2015

  • Tanifuji, Kazuki; Lee, Chi Chung; Ohki, Yasuhiro
  • Angewandte Chemie, Vol. 127, Issue 47
  • DOI: 10.1002/ange.201507646

Molecular insights into nitrogenase FeMoco insertion – The role of His 274 and His 451 of MoFe protein α subunit
journal, November 2007

Conformational Differences between Azotobacter vinelandii Nitrogenase MoFe Proteins As Studied by Small-Angle X-ray Scattering †
journal, July 2007

  • Corbett, Mary C.; Hu, Yilin; Fay, Aaron W.
  • Biochemistry, Vol. 46, Issue 27
  • DOI: 10.1021/bi7005064

Mechanism of Molybdenum Nitrogenase
journal, January 1996

  • Burgess, Barbara K.; Lowe, David J.
  • Chemical Reviews, Vol. 96, Issue 7
  • DOI: 10.1021/cr950055x

Conformational variability in structures of the nitrogenase iron proteins from Azotobacter vinelandii and Clostridium pasteurianum
journal, July 1998

  • Schlessman, Jamie L.; Woo, Deborah; Joshua-Tor, Leemor
  • Journal of Molecular Biology, Vol. 280, Issue 4
  • DOI: 10.1006/jmbi.1998.1898

X-ray Emission Spectroscopy Evidences a Central Carbon in the Nitrogenase Iron-Molybdenum Cofactor
journal, November 2011

Vanadium Nitrogenase Reduces CO
journal, August 2010

Catalytic Reduction of CN − , CO, and CO 2 by Nitrogenase Cofactors in Lanthanide-Driven Reactions
journal, November 2014

  • Lee, Chi Chung; Hu, Yilin; Ribbe, Markus W.
  • Angewandte Chemie International Edition, Vol. 54, Issue 4
  • DOI: 10.1002/anie.201410412

Catalytic Reduction of N 2 to NH 3 by an Fe–N 2 Complex Featuring a C-Atom Anchor
journal, January 2014

  • Creutz, Sidney E.; Peters, Jonas C.
  • Journal of the American Chemical Society, Vol. 136, Issue 3
  • DOI: 10.1021/ja4114962

Structure and Reactivity of an Asymmetric Synthetic Mimic of Nitrogenase Cofactor
journal, November 2016

  • Tanifuji, Kazuki; Sickerman, Nathaniel; Lee, Chi Chung
  • Angewandte Chemie International Edition, Vol. 55, Issue 50
  • DOI: 10.1002/anie.201608806

Nitrogenase MoFe-Protein at 1.16 A Resolution: A Central Ligand in the FeMo-Cofactor
journal, September 2002

Structure and Properties of a Synthetic Analogue of Bacterial Iron-Sulfur Proteins
journal, September 1972

  • Herskovitz, T.; Averill, B. A.; Holm, R. H.
  • Proceedings of the National Academy of Sciences, Vol. 69, Issue 9
  • DOI: 10.1073/pnas.69.9.2437

Reduction of Dinitrogen to Ammonia at a Well-Protected Reaction Site in a Molybdenum Triamidoamine Complex
journal, June 2002

  • Yandulov, Dmitry V.; Schrock, Richard R.
  • Journal of the American Chemical Society, Vol. 124, Issue 22
  • DOI: 10.1021/ja020186x

NifS-directed assembly of a transient [2Fe-2S] cluster within the NifU protein
journal, January 2000

  • Yuvaniyama, P.; Agar, J. N.; Cash, V. L.
  • Proceedings of the National Academy of Sciences, Vol. 97, Issue 2
  • DOI: 10.1073/pnas.97.2.599

Catalytic Reduction of CN − , CO, and CO 2 by Nitrogenase Cofactors in Lanthanide-Driven Reactions
journal, November 2014

  • Lee, Chi Chung; Hu, Yilin; Ribbe, Markus W.
  • Angewandte Chemie, Vol. 127, Issue 4
  • DOI: 10.1002/ange.201410412

Diazenido (iminonitrosyl) (N2H), Hydrazido(2-) (N2H2, and hydrazido(1-) (N2H3) ligands as intermediates in the reduction of ligating dinitrogen to ammonia
journal, November 1975

  • Chatt, Joseph; Pearman, Alan J.; Richards, Raymond L.
  • Journal of Organometallic Chemistry, Vol. 101, Issue 3
  • DOI: 10.1016/S0022-328X(00)92481-1

Biosynthesis of the Metalloclusters of Nitrogenases
journal, June 2016

Structure−Function Relationships of Alternative Nitrogenases
journal, January 1996

The nifU, nifS and nifV gene products are required for activity of all three nitrogenases of Azotobacter vinelandii
journal, February 1992

  • Kennedy, Christina; Dean, Dennis
  • MGG Molecular & General Genetics, Vol. 231, Issue 3
  • DOI: 10.1007/BF00292722

Refining the pathway of carbide insertion into the nitrogenase M-cluster
journal, August 2015

  • Wiig, Jared A.; Hu, Yilin; Ribbe, Markus W.
  • Nature Communications, Vol. 6, Issue 1
  • DOI: 10.1038/ncomms9034

NifEN-B complex of Azotobacter vinelandii is fully functional in nitrogenase FeMo cofactor assembly
journal, May 2011

  • Wiig, J. A.; Hu, Y.; Ribbe, M. W.
  • Proceedings of the National Academy of Sciences, Vol. 108, Issue 21
  • DOI: 10.1073/pnas.1102773108

X-ray Spectroscopic Observation of an Interstitial Carbide in NifEN-Bound FeMoco Precursor
journal, December 2012

  • Lancaster, Kyle M.; Hu, Yilin; Bergmann, Uwe
  • Journal of the American Chemical Society, Vol. 135, Issue 2
  • DOI: 10.1021/ja309254g

Formation of a Nitrogenase P-cluster [Fe 8 S 7 ] Core via Reductive Fusion of Two All-Ferric [Fe 4 S 4 ] Clusters
journal, July 2012

  • Ohki, Yasuhiro; Tanifuji, Kazuki; Yamada, Norihiro
  • Chemistry - An Asian Journal, Vol. 7, Issue 10
  • DOI: 10.1002/asia.201200568

FeMo cofactor maturation on NifEN
journal, October 2006

  • Hu, Y.; Corbett, M. C.; Fay, A. W.
  • Proceedings of the National Academy of Sciences, Vol. 103, Issue 46
  • DOI: 10.1073/pnas.0602647103

Molybdenum−Iron−Sulfur Clusters of Nuclearities Eight and Sixteen, Including a Topological Analogue of the P-Cluster of Nitrogenase
journal, January 2001

  • Osterloh, Frank; Achim, Catalina; Holm, R. H.
  • Inorganic Chemistry, Vol. 40, Issue 2
  • DOI: 10.1021/ic000617h

P-cluster maturation on nitrogenase MoFe protein
journal, June 2007

  • Hu, Y.; Fay, A. W.; Lee, C. C.
  • Proceedings of the National Academy of Sciences, Vol. 104, Issue 25
  • DOI: 10.1073/pnas.0704297104

Developments in the Biomimetic Chemistry of Cubane-Type and Higher Nuclearity Iron–Sulfur Clusters
journal, January 2014

  • Lee, Sonny C.; Lo, Wayne; Holm, R. H.
  • Chemical Reviews, Vol. 114, Issue 7
  • DOI: 10.1021/cr4004067

ATP-Independent Formation of Hydrocarbons Catalyzed by Isolated Nitrogenase Cofactors
journal, January 2012

  • Lee, Chi Chung; Hu, Yilin; Ribbe, Markus W.
  • Angewandte Chemie International Edition, Vol. 51, Issue 8
  • DOI: 10.1002/anie.201108916

Combining a Nitrogenase Scaffold and a Synthetic Compound into an Artificial Enzyme
journal, October 2015

  • Tanifuji, Kazuki; Lee, Chi Chung; Ohki, Yasuhiro
  • Angewandte Chemie International Edition, Vol. 54, Issue 47
  • DOI: 10.1002/anie.201507646

A comprehensive mechanism for the Fischer-Tropsch synthesis
journal, October 1981

Characterization of Isolated Nitrogenase FeVco
journal, September 2010

  • Fay, Aaron W.; Blank, Michael A.; Lee, Chi Chung
  • Journal of the American Chemical Society, Vol. 132, Issue 36
  • DOI: 10.1021/ja1019657

The reduction of mono-coordinated molecular nitrogen to ammonia in a protic environment
journal, January 1975

  • Chatt, J.; Pearman, A. J.; Richards, R. L.
  • Nature, Vol. 253, Issue 5486
  • DOI: 10.1038/253039b0

Widening the Product Profile of Carbon Dioxide Reduction by Vanadium Nitrogenase
journal, August 2015

  • Rebelein, Johannes G.; Hu, Yilin; Ribbe, Markus W.
  • ChemBioChem, Vol. 16, Issue 14
  • DOI: 10.1002/cbic.201500305

Structural Conversions of Synthetic and Protein-Bound Iron–Sulfur Clusters
journal, October 2016

Anionic iron carbido carbonyl clusters with sulfur dioxide ligands
journal, June 1988

  • Bogdan, P. L.; Sabat, M.; Sunshine, S. A.
  • Inorganic Chemistry, Vol. 27, Issue 11
  • DOI: 10.1021/ic00284a018

A New Entry into Molybdenum/Tungsten Sulfur Chemistry:  Synthesis and Reactions of Mononuclear Sulfido Complexes of Pentamethylcyclopentadienyl−Molybdenum(VI) and −Tungsten(VI)
journal, October 1997

  • Kawaguchi, Hiroyuki; Yamada, Kazuhiro; Lang, Jian-Ping
  • Journal of the American Chemical Society, Vol. 119, Issue 43
  • DOI: 10.1021/ja971725e

Abiological Iron−Sulfur Clusters
journal, September 1998

  • Ogino, Hiroshi; Inomata, Shinji; Tobita, Hiromi
  • Chemical Reviews, Vol. 98, Issue 6
  • DOI: 10.1021/cr940081f

Impact of ligands and media on the structure and properties of biological and biomimetic iron-sulfur clusters
journal, May 2017

Maturation of nitrogenase cofactor — the role of a class E radical SAM methyltransferase NifB
journal, April 2016

Binding of dinitrogen to an iron–sulfur–carbon site
journal, September 2015

  • Čorić, Ilija; Mercado, Brandon Q.; Bill, Eckhard
  • Nature, Vol. 526, Issue 7571
  • DOI: 10.1038/nature15246

Facile Route to the Trithiotungsten(VI) Complex (PPh4)[(C5Me5)W(S)3] via Carbon-Sulfur Bond Cleavage of Ethanedithiolate and Its Reactions with Alkyl Halides and Alkynes
journal, April 1995

  • Kawaguchi, Hiroyuki; Tatsumi, Kazuyuki
  • Journal of the American Chemical Society, Vol. 117, Issue 13
  • DOI: 10.1021/ja00118a032

A review of the existing and alternative methods for greener nitrogen fixation
journal, April 2015

  • Cherkasov, N.; Ibhadon, A. O.; Fitzpatrick, P.
  • Chemical Engineering and Processing: Process Intensification, Vol. 90
  • DOI: 10.1016/j.cep.2015.02.004

Controlled Expression of nif and isc Iron-Sulfur Protein Maturation Components Reveals Target Specificity and Limited Functional Replacement between the Two Systems
journal, January 2007

  • Dos Santos, P. C.; Johnson, D. C.; Ragle, B. E.
  • Journal of Bacteriology, Vol. 189, Issue 7
  • DOI: 10.1128/JB.01734-06

Rational design of metalloenzymes: From single to multiple active sites
journal, April 2017

Structure of a Cofactor-Deficient Nitrogenase MoFe Protein
journal, April 2002

Nitrogenase: a general hydrogenator of small molecules
journal, January 2013

Conversion of dinitrogen in its molybdenum and tungsten complexes into ammonia and possible relevance to the nitrogenase reaction
journal, January 1977

  • Chatt, Joseph; Pearman, Alan J.; Richards, Raymond L.
  • Journal of the Chemical Society, Dalton Transactions, Issue 19
  • DOI: 10.1039/dt9770001852

Identification of iron-sulfur centers in the iron-molybdenum proteins of nitrogenase.
journal, October 1979

  • Kurtz, D. M.; McMillan, R. S.; Burgess, B. K.
  • Proceedings of the National Academy of Sciences, Vol. 76, Issue 10
  • DOI: 10.1073/pnas.76.10.4986

Carbonyl nitrosyl clusters. Syntheses and structures of [Fe5C(CO)13(NO)]-, [Fe6C(CO)13(NO)2]2-, and [Fe3(CO)8(NO)(NH)]-
journal, December 1986

Radical SAM-Dependent Carbon Insertion into the Nitrogenase M-Cluster
journal, September 2012

Catalytic Reduction of Dinitrogen to Ammonia at a Single Molybdenum Center
journal, July 2003

Evidence for Interstitial Carbon in Nitrogenase FeMo Cofactor
journal, November 2011

Catalytic Synthesis of Ammonia—A “Never-Ending Story”?
journal, May 2003

Molecular insights into nitrogenase FeMo cofactor insertion: the role of His 362 of the MoFe protein α subunit in FeMo cofactor incorporation
journal, January 2007

  • Hu, Yilin; Fay, Aaron W.; Ribbe, Markus W.
  • JBIC Journal of Biological Inorganic Chemistry, Vol. 12, Issue 4
  • DOI: 10.1007/s00775-006-0199-1

Katalytische Ammoniaksynthese – eine “unendliche Geschichte”?
journal, May 2003

Extending the Carbon Chain: Hydrocarbon Formation Catalyzed by Vanadium/Molybdenum Nitrogenases
journal, August 2011

Synthetic analogs of the active sites of iron-sulfur proteins. II. Synthesis and structure of the tetra[mercapto-.mu.3-sulfido-iron] clusters, [Fe4S4(SR)4]2-
journal, May 1973

  • Averill, B. A.; Herskovitz, T.; Holm, R. H.
  • Journal of the American Chemical Society, Vol. 95, Issue 11
  • DOI: 10.1021/ja00792a013

Assembly scaffold NifEN: A structural and functional homolog of the nitrogenase catalytic component
journal, August 2016

  • Fay, Aaron W.; Blank, Michael A.; Rebelein, Johannes G.
  • Proceedings of the National Academy of Sciences, Vol. 113, Issue 34
  • DOI: 10.1073/pnas.1609574113

Isolation of an iron-molybdenum cofactor from nitrogenase
journal, August 1977

  • Shah, V. K.; Brill, W. J.
  • Proceedings of the National Academy of Sciences, Vol. 74, Issue 8
  • DOI: 10.1073/pnas.74.8.3249

CATALYTIC REDUCTION OF HYDRAZINE TO AMMONIA BY THE REDUCED SPECIES OF [Mo 2 Fe 6 S 8 L 9 ] 3− AND [Fe 4 S 4 L 4 ] 2− (L=SPh, SCH 2 CH 2 OH)
journal, June 1983

  • Hozumi, Yoshiyuki; Imasaka, Yoshinobu; Tanaka, Koji
  • Chemistry Letters, Vol. 12, Issue 6
  • DOI: 10.1246/cl.1983.897
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    A Comparative Analysis of the CO-Reducing Activities of MoFe Proteins Containing Mo- and V-Nitrogenase Cofactors
    journal, February 2018

    N 2 Reduction on Fe‐Based Complexes with Different Supporting Main‐Group Elements: Critical Roles of Anchor and Peripheral Ligands
    journal, October 2018

    Metallo-supramolecular assembly of protic pincer-type complexes: encapsulation of dinitrogen and carbon disulfide into a multiproton-responsive diruthenium cage
    journal, January 2019

    • Toda, Tatsuro; Suzuki, Satoshi; Kuwata, Shigeki
    • Chemical Communications, Vol. 55, Issue 8
    • DOI: 10.1039/c8cc08384c

    Synthesis and reactivity of asymmetric Cr( i ) dinitrogen complexes supported by cyclopentadienyl–phosphine ligands
    journal, January 2019

    • Li, Jiapeng; Yin, Jianhao; Wang, Gao-Xiang
    • Chemical Communications, Vol. 55, Issue 65
    • DOI: 10.1039/c9cc02960e

    A Cu/Zn heterometallic complex with solvent-binding cavity, catalytic activity for the oxidation of 1-phenylethanol and unusual magnetic properties
    journal, January 2019

    • Mielcarek, Agnieszka; Bieńko, Alina; Saramak, Paulina
    • Dalton Transactions, Vol. 48, Issue 48
    • DOI: 10.1039/c9dt03304a
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