Ultra-low field MRI: bringing MRI to new arenas

Magnelind, Per Erik; Matlashov, Andrei Nikolaevich; Newman, Shaun Garrett; Sandin, Henrik; Urbaitis, Algis V.; Volegov, Petr Lvovich; Espy, Michelle A.

Title: Ultra-low field MRI: bringing MRI to new arenas

Full Record
Other Related Research

Abstract

Conventional magnetic resonance imaging (MRI) is moving toward the use of stronger and stronger magnetic fields with 3T, and even 7 T systems being increasingly used in routine clinical applications. However there is another branch of MRI, namely Ultra Low Field MRI (ULF-MRI) where the magnetic fields during readout are several orders of magnitude smaller, namely 1–100 μT. While conventional high-field MRI remains the gold standard there are several situations such as in military emergencies or in developing countries where for cost and logistical reasons, conventional MRI is not practical. In such scenarios, ULF-MRI could provide a solution. Lastly, this article describes the basic principles and the potential of ULF-MRI.

Authors:

^[1]; Matlashov, Andrei Nikolaevich ^[1];

^[1]; Sandin, Henrik ^[1];

^[1]; Volegov, Petr Lvovich ^[1];

^[1]

Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

Publication Date:: Tue Nov 01 00:00:00 EDT 2016

Research Org.:: Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

Sponsoring Org.:: USDOE Laboratory Directed Research and Development (LDRD) Program

OSTI Identifier:: 1351230

Report Number(s):: LA-UR-16-27869
Journal ID: ISSN 1461-0051

Grant/Contract Number:: AC52-06NA25396

Resource Type:: Accepted Manuscript

Journal Name:: Diagnostic Imaging Europe

Additional Journal Information:: Journal Name: Diagnostic Imaging Europe; Journal ID: ISSN 1461-0051

Publisher:: DI Europe

Country of Publication:: United States

Language:: English

Subject:: 62 RADIOLOGY AND NUCLEAR MEDICINE; 59 BASIC BIOLOGICAL SCIENCES; Biological Science; Magnetic Resonance Imaging

Citation Formats


                    Magnelind, Per Erik, Matlashov, Andrei Nikolaevich, Newman, Shaun Garrett, Sandin, Henrik, Urbaitis, Algis V., Volegov, Petr Lvovich, and Espy, Michelle A. Ultra-low field MRI: bringing MRI to new arenas.  United States: N. p., 2016. 
Web.

Copy to clipboard


                    Magnelind, Per Erik, Matlashov, Andrei Nikolaevich, Newman, Shaun Garrett, Sandin, Henrik, Urbaitis, Algis V., Volegov, Petr Lvovich, & Espy, Michelle A. Ultra-low field MRI: bringing MRI to new arenas.  United States.

Copy to clipboard


                    Magnelind, Per Erik, Matlashov, Andrei Nikolaevich, Newman, Shaun Garrett, Sandin, Henrik, Urbaitis, Algis V., Volegov, Petr Lvovich, and Espy, Michelle A. Tue .  
"Ultra-low field MRI: bringing MRI to new arenas".  United States.  https://www.osti.gov/servlets/purl/1351230.

Copy to clipboard


                    
@article{osti_1351230,

  title        = {Ultra-low field MRI: bringing MRI to new arenas},

  author       = {Magnelind, Per Erik and Matlashov, Andrei Nikolaevich and Newman, Shaun Garrett and Sandin, Henrik and Urbaitis, Algis V. and Volegov, Petr Lvovich and Espy, Michelle A.},

  abstractNote = {Conventional magnetic resonance imaging (MRI) is moving toward the use of stronger and stronger magnetic fields with 3T, and even 7 T systems being increasingly used in routine clinical applications. However there is another branch of MRI, namely Ultra Low Field MRI (ULF-MRI) where the magnetic fields during readout are several orders of magnitude smaller, namely 1–100 μT. While conventional high-field MRI remains the gold standard there are several situations such as in military emergencies or in developing countries where for cost and logistical reasons, conventional MRI is not practical. In such scenarios, ULF-MRI could provide a solution. Lastly, this article describes the basic principles and the potential of ULF-MRI.},

  doi          = {},

  journal      = {Diagnostic Imaging Europe},

  number       = ,

  volume       = ,

  place        = {United States},

  year         = {Tue Nov 01 00:00:00 EDT 2016},

  month        = {Tue Nov 01 00:00:00 EDT 2016}

}

Copy to clipboard

Journal Article:

Free Publicly Available Full Text

Accepted Manuscript (DOE)

Publisher's Version of Record

The DOI is not currently available

Other availability

Search WorldCat to find libraries that may hold this journal

Save / Share:

Export Metadata

Save to My Library

Similar Records in DOE PAGES and OSTI.GOV collections:

Progress on detection of liquid explosives using ultra-low field MRI

Conference Espy, Michelle A ; Matlashov, Andrei N ; Volegov, Petr L ; ...

Nuclear magnetic resonance (NMR) and magnetic resonance imaging (MRI) methods are widely used in medicine, chemistry and industry. Over the past several years there has been increasing interest in performing NMR and MRI in the ultra-low field (ULF) regime, with measurement field strengths of 10-100 microTesla and pre-polarization fields of 30-50 mTesla. The real-time signal-to-noise ratio for such measurements is about 100. Our group at LANL has built and demonstrated the performance of SQUID-based ULF NMR/MRI instrumentation for classification of materials and detection of liquid explosives via their relaxation properties measured at ULF, using T{sub 1}, and T{sub 2}, andmore »« less
https://doi.org/10.1109/TASC.2011.2105235

Full Text Available
High-sensitivity in vivo contrast for ultra-low field magnetic resonance imaging using superparamagnetic iron oxide nanoparticles

Journal Article Waddington, David E. J. ; Boele, Thomas ; Maschmeyer, Richard ; ... - Science Advances

Magnetic resonance imaging (MRI) scanners operating at ultra-low magnetic fields (ULF; <10 mT) are uniquely positioned to reduce the cost and expand the clinical accessibility of MRI. A fundamental challenge for ULF MRI is obtaining high-contrast images without compromising acquisition sensitivity to the point that scan times become clinically unacceptable. Here, we demonstrate that the high magnetization of superparamagnetic iron oxide nanoparticles (SPIONs) at ULF makes possible relaxivity- and susceptibility-based effects unachievable with conventional contrast agents (CAs). We leverage these effects to acquire high-contrast images of SPIONs in a rat model with ULF MRI using short scan times. This workmore »« less
https://doi.org/10.1126/sciadv.abb0998

Full Text Available
Impact of the MLC on the MRI field distortion of a prototype MRI-linac

Journal Article Kolling, Stefan ; Keall, Paul ; Oborn, Brad - Medical Physics

Purpose: To cope with intrafraction tumor motion, integrated MRI-linac systems for real-time image guidance are currently under development. The multileaf collimator (MLC) is a key component in every state-of-the-art radiotherapy treatment system, allowing for accurate field shaping and tumor tracking. This work quantifies the magnetic impact of a widely used MLC on the MRI field homogeneity for such a modality.Methods: The finite element method was employed to model a MRI-linac assembly comprised of a 1.0 T split-bore MRI magnet and the key ferromagnetic components of a Varian Millennium 120 MLC, namely, the leaves and motors. Full 3D magnetic field maps ofmore »« less
https://doi.org/10.1118/1.4828792
Philips 3T Intera Magnetic Resonance Imaging System and Upgrade of existing MRI equipment

Technical Report Evanochko, William T

The objective of this proposal was twofold. First, upgrade existing MRI equipment, specifically a research 4.1T whole-body system. Second, purchase a clinical, state-of-the-art 3T MRI system tailored specifically to cardiovascular and neurological applications. This project was within the guidelines of ''Medical Applications and Measurement Science''. The goals were: [1] to develop beneficial applications of magnetic resonance imaging; [2] discover new applications of MR strategies for medical research; and [2] apply them for clinical diagnosis. Much of this proposal searched for breakthroughs in this noninvasive and nondestructive imaging technology. Finally, this proposal's activities focused on research in the basic science ofmore »« less
https://doi.org/10.2172/834766

Full Text Available
An RF dosimeter for independent SAR measurement in MRI scanners

Journal Article Qian, Di ; Bottomley, Paul A. ; El-Sharkawy, AbdEl-Monem M. ; ... - Medical Physics

Purpose: The monitoring and management of radio frequency (RF) exposure is critical for ensuring magnetic resonance imaging (MRI) safety. Commercial MRI scanners can overestimate specific absorption rates (SAR) and improperly restrict clinical MRI scans or the application of new MRI sequences, while underestimation of SAR can lead to tissue heating and thermal injury. Accurate scanner-independent RF dosimetry is essential for measuring actual exposure when SAR is critical for ensuring regulatory compliance and MRI safety, for establishing RF exposure while evaluating interventional leads and devices, and for routine MRI quality assessment by medical physicists. However, at present there are no scanner-independentmore »« less
https://doi.org/10.1118/1.4829527

Similar Records