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Title: An artificial metalloenzyme with the kinetics of native enzymes

Authors:
; ; ; ; ; ;
Publication Date:
Sponsoring Org.:
USDOE
OSTI Identifier:
1345710
Grant/Contract Number:  
AC02-05CH11231
Resource Type:
Published Article
Journal Name:
Science
Additional Journal Information:
Journal Name: Science Journal Volume: 354 Journal Issue: 6308; Journal ID: ISSN 0036-8075
Publisher:
American Association for the Advancement of Science (AAAS)
Country of Publication:
United States
Language:
English

Citation Formats

Dydio, P., Key, H. M., Nazarenko, A., Rha, J. Y. -. E., Seyedkazemi, V., Clark, D. S., and Hartwig, J. F. An artificial metalloenzyme with the kinetics of native enzymes. United States: N. p., 2016. Web. doi:10.1126/science.aah4427.
Dydio, P., Key, H. M., Nazarenko, A., Rha, J. Y. -. E., Seyedkazemi, V., Clark, D. S., & Hartwig, J. F. An artificial metalloenzyme with the kinetics of native enzymes. United States. https://doi.org/10.1126/science.aah4427
Dydio, P., Key, H. M., Nazarenko, A., Rha, J. Y. -. E., Seyedkazemi, V., Clark, D. S., and Hartwig, J. F. Thu . "An artificial metalloenzyme with the kinetics of native enzymes". United States. https://doi.org/10.1126/science.aah4427.
@article{osti_1345710,
title = {An artificial metalloenzyme with the kinetics of native enzymes},
author = {Dydio, P. and Key, H. M. and Nazarenko, A. and Rha, J. Y. -. E. and Seyedkazemi, V. and Clark, D. S. and Hartwig, J. F.},
abstractNote = {},
doi = {10.1126/science.aah4427},
journal = {Science},
number = 6308,
volume = 354,
place = {United States},
year = {Thu Oct 06 00:00:00 EDT 2016},
month = {Thu Oct 06 00:00:00 EDT 2016}
}

Journal Article:
Free Publicly Available Full Text
Publisher's Version of Record
https://doi.org/10.1126/science.aah4427

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Cited by: 219 works
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Works referenced in this record:

P450 BM3 -Axial Mutations: A Gateway to Non-Natural Reactivity
journal, August 2014

  • Hyster, Todd K.; Arnold, Frances H.
  • Israel Journal of Chemistry, Vol. 55, Issue 1
  • DOI: 10.1002/ijch.201400080

Enantioselective Total Synthesis of (−)-Incarviatone A
journal, September 2015

  • Hong, Benke; Li, Chao; Wang, Zhen
  • Journal of the American Chemical Society, Vol. 137, Issue 37
  • DOI: 10.1021/jacs.5b08551

Potassium N -Iodo p -Toluenesulfonamide (TsNIK, Iodamine-T): A New Reagent for the Oxidation of Hydrazones to Diazo Compounds
journal, March 2014

  • Nicolle, Simon M.; Moody, Christopher J.
  • Chemistry - A European Journal, Vol. 20, Issue 15
  • DOI: 10.1002/chem.201304656

Roles of key active-site residues in flavocytochrome P450 BM3
journal, April 1999

  • Noble, Michael A.; Miles, Caroline S.; Chapman, Stephen K.
  • Biochemical Journal, Vol. 339, Issue 2
  • DOI: 10.1042/bj3390371

Engineering a dirhodium artificial metalloenzyme for selective olefin cyclopropanation
journal, July 2015

  • Srivastava, Poonam; Yang, Hao; Ellis-Guardiola, Ken
  • Nature Communications, Vol. 6, Issue 1
  • DOI: 10.1038/ncomms8789

The use of differential scanning fluorimetry to detect ligand interactions that promote protein stability
journal, September 2007

  • Niesen, Frank H.; Berglund, Helena; Vedadi, Masoud
  • Nature Protocols, Vol. 2, Issue 9
  • DOI: 10.1038/nprot.2007.321

Enzymes for chemical synthesis
journal, January 2001

  • Koeller, Kathryn M.; Wong, Chi-Huey
  • Nature, Vol. 409, Issue 6817
  • DOI: 10.1038/35051706

Merging the best of two worlds: artificial metalloenzymes for enantioselective catalysis
journal, January 2011

  • Ringenberg, Mark R.; Ward, Thomas R.
  • Chemical Communications, Vol. 47, Issue 30
  • DOI: 10.1039/c1cc11592h

Dynamic Kinetic Resolution of 2,3-Dihydrobenzo[ b ]furans: Chemoenzymatic Synthesis of Analgesic Agent BRL 37959
journal, July 2012

  • Bongen, Patrick; Pietruszka, Jörg; Simon, Robert Christian
  • Chemistry - A European Journal, Vol. 18, Issue 35
  • DOI: 10.1002/chem.201200683

Iridium( iii )-bis(imidazolinyl)phenyl catalysts for enantioselective C–H functionalization with ethyl diazoacetate
journal, January 2016

  • Weldy, N. Mace; Schafer, A. G.; Owens, C. P.
  • Chemical Science, Vol. 7, Issue 5
  • DOI: 10.1039/C6SC00190D

NMR Chemical Shifts of Trace Impurities: Common Laboratory Solvents, Organics, and Gases in Deuterated Solvents Relevant to the Organometallic Chemist
journal, May 2010

  • Fulmer, Gregory R.; Miller, Alexander J. M.; Sherden, Nathaniel H.
  • Organometallics, Vol. 29, Issue 9
  • DOI: 10.1021/om100106e

Artificial Metalloenzymes and Metallopeptide Catalysts for Organic Synthesis
journal, November 2013


Characterization of the Peroxidase Activity of CYP119, a Thermostable P450 FromSulfolobus acidocaldarius
journal, February 2008

  • Rabe, Kersten S.; Kiko, Kathrin; Niemeyer, Christof M.
  • ChemBioChem, Vol. 9, Issue 3
  • DOI: 10.1002/cbic.200700450

Dynamic Enzymatic Kinetic Resolution of Methyl 2,3-Dihydro-1 H -indene-1-carboxylate
journal, December 2009

  • Pietruszka, Jörg; Simon, Robert Christian; Kruska, Fabian
  • European Journal of Organic Chemistry, Vol. 2009, Issue 35
  • DOI: 10.1002/ejoc.200901025

Iron-Catalyzed Intramolecular Allylic C–H Amination
journal, January 2012

  • Paradine, Shauna M.; White, M. Christina
  • Journal of the American Chemical Society, Vol. 134, Issue 4
  • DOI: 10.1021/ja211600g

Regio- and Enantioselective Alkane Hydroxylation with Engineered Cytochromes P450 BM-3
journal, November 2003

  • Peters, Matthew W.; Meinhold, Peter; Glieder, Anton
  • Journal of the American Chemical Society, Vol. 125, Issue 44, p. 13442-13450
  • DOI: 10.1021/ja0303790

Abiological catalysis by artificial haem proteins containing noble metals in place of iron
journal, June 2016

  • Key, Hanna M.; Dydio, Paweł; Clark, Douglas S.
  • Nature, Vol. 534, Issue 7608
  • DOI: 10.1038/nature17968

The Moderately Efficient Enzyme: Evolutionary and Physicochemical Trends Shaping Enzyme Parameters
journal, May 2011

  • Bar-Even, Arren; Noor, Elad; Savir, Yonatan
  • Biochemistry, Vol. 50, Issue 21
  • DOI: 10.1021/bi2002289

Cytochrome P450 Catalyzed Oxidative Hydroxylation of Achiral Organic Compounds with Simultaneous Creation of Two Chirality Centers in a Single CH Activation Step
journal, March 2014

  • Roiban, Gheorghe-Doru; Agudo, Rubén; Reetz, Manfred T.
  • Angewandte Chemie International Edition, Vol. 53, Issue 33
  • DOI: 10.1002/anie.201310892

Enantio- and Diastereoselective Synthesis of cis -2-Aryl-3-methoxycarbonyl-2,3-dihydrobenzofurans via the Rh(II)-Catalyzed C−H Insertion Process
journal, October 2002

  • Saito, Hiroaki; Oishi, Hiroyuki; Kitagaki, Shinji
  • Organic Letters, Vol. 4, Issue 22
  • DOI: 10.1021/ol0267127

Negishi Coupling of Secondary Alkylzinc Halides with Aryl Bromides and Chlorides
journal, June 2009

  • Han, Chong; Buchwald, Stephen L.
  • Journal of the American Chemical Society, Vol. 131, Issue 22
  • DOI: 10.1021/ja902046m

Structural Adaptability Facilitates Histidine Heme Ligation in a Cytochrome P450
journal, September 2015

  • McIntosh, John A.; Heel, Thomas; Buller, Andrew R.
  • Journal of the American Chemical Society, Vol. 137, Issue 43
  • DOI: 10.1021/jacs.5b07107

BIOCHEMISTRY: How Enzymes Work
journal, June 2008