Large scale nanoparticle screening for small molecule analysis in laser desorption ionization mass spectrometry

Yagnik, Gargey B.; Hansen, Rebecca L.; Korte, Andrew R.; Reichert, Malinda D.; Vela, Javier; Lee, Young Jin

doi:10.1021/acs.analchem.6b02732

Title: Large scale nanoparticle screening for small molecule analysis in laser desorption ionization mass spectrometry

Journal Article · Tue Aug 30 00:00:00 EDT 2016 · Analytical Chemistry

DOI: https://doi.org/10.1021/acs.analchem.6b02732 · OSTI ID:1337675

Yagnik, Gargey B. ^[1]; Hansen, Rebecca L. ^[1]; Korte, Andrew R. ^[1]; Reichert, Malinda D. ^[2]; Vela, Javier ^[1]; Lee, Young Jin ^[1]

Iowa State Univ., Ames, IA (United States); Ames Lab., Ames, IA (United States)
Iowa State Univ., Ames, IA (United States)

Nanoparticles (NPs) have been suggested as efficient matrixes for small molecule profiling and imaging by laser-desorption ionization mass spectrometry (LDI-MS), but so far there has been no systematic study comparing different NPs in the analysis of various classes of small molecules. Here, we present a large scale screening of 13 NPs for the analysis of two dozen small metabolite molecules. Many NPs showed much higher LDI efficiency than organic matrixes in positive mode and some NPs showed comparable efficiencies for selected analytes in negative mode. Our results suggest that a thermally driven desorption process is a key factor for metal oxide NPs, but chemical interactions are also very important, especially for other NPs. Furthermore, the screening results provide a useful guideline for the selection of NPs in the LDI-MS analysis of small molecules.

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Research Organization:: Ames Laboratory (AMES), Ames, IA (United States)

Sponsoring Organization:: USDOE Office of Science (SC), Basic Energy Sciences (BES) (SC-22)

Grant/Contract Number:: AC02-07CH11358

OSTI ID:: 1337675

Report Number(s):: IS-J--8992

Journal Information:: Analytical Chemistry, Journal Name: Analytical Chemistry Journal Issue: 18 Vol. 88; ISSN 0003-2700

Publisher:: American Chemical Society (ACS)Copyright Statement

Country of Publication:: United States

Language:: English

References (46)

MALDI-MS analysis and imaging of small molecule metabolites with 1,5-diaminonaphthalene (DAN): Diaminonaphthalene as small molecule MALDI matrix Korte, Andrew R.; Lee, Young Jin Journal of Mass Spectrometry, Vol. 49, Issue 8 https://doi.org/10.1002/jms.3400	journal	July 2014
Quantum dots laser desorption/ionization MS: multifunctional CdSe quantum dots as the matrix, concentrating probes and acceleration for microwave enzymatic digestion for peptide analysis and high resolution detection of proteins in a linear MALDI-TOF MS Shrivas, Kamlesh; Kailasa, Suresh Kumar; Wu, Hui-Fen PROTEOMICS, Vol. 9, Issue 10 https://doi.org/10.1002/pmic.200800772	journal	May 2009
On-plate-selective enrichment of glycopeptides using boronic acid-modified gold nanoparticles for direct MALDI-QIT-TOF MS analysis Tang, Jia; Liu, Yingchao; Qi, Dawei PROTEOMICS, Vol. 9, Issue 22 https://doi.org/10.1002/pmic.200900033	journal	November 2009
Protein and polymer analyses up tom/z 100 000 by laser ionization time-of-flight mass spectrometry Tanaka, Koichi; Waki, Hiroaki; Ido, Yutaka Rapid Communications in Mass Spectrometry, Vol. 2, Issue 8 https://doi.org/10.1002/rcm.1290020802	journal	August 1988
Platinum vapor deposition surface-assisted laser desorption/ionization for imaging mass spectrometry of small molecules: SALDI-IMS of small molecules using platinum vapor deposition Kawasaki, Hideya; Ozawa, Tomoyuki; Hisatomi, Hirotaka Rapid Communications in Mass Spectrometry, Vol. 26, Issue 16 https://doi.org/10.1002/rcm.6301	journal	July 2012
Gold nanomaterials as a new tool for bioanalytical applications of laser desorption ionization mass spectrometry Pilolli, Rosa; Palmisano, Francesco; Cioffi, Nicola Analytical and Bioanalytical Chemistry, Vol. 402, Issue 2 https://doi.org/10.1007/s00216-011-5120-2	journal	June 2011
Imaging of lipids in rat heart by MALDI-MS with silver nanoparticles Jackson, Shelley N.; Baldwin, Kathrine; Muller, Ludovic Analytical and Bioanalytical Chemistry, Vol. 406, Issue 5 https://doi.org/10.1007/s00216-013-7525-6	journal	December 2013
Development of Laser Desorption Imaging Mass Spectrometry Methods to Investigate the Molecular Composition of Latent Fingermarks Lauzon, Nidia; Dufresne, Martin; Chauhan, Vinita Journal of The American Society for Mass Spectrometry, Vol. 26, Issue 6 https://doi.org/10.1007/s13361-015-1123-0	journal	April 2015
Profiling and Imaging Ion Mobility-Mass Spectrometry Analysis of Cholesterol and 7-Dehydrocholesterol in Cells Via Sputtered Silver MALDI Xu, Libin; Kliman, Michal; Forsythe, Jay G. Journal of The American Society for Mass Spectrometry, Vol. 26, Issue 6 https://doi.org/10.1007/s13361-015-1131-0	journal	March 2015
Desorption–ionization on silicon mass spectrometry: an application in forensics Thomas, John J.; Shen, Zhouxin; Blackledge, Robert Analytica Chimica Acta, Vol. 442, Issue 2 https://doi.org/10.1016/S0003-2670(01)01107-2	journal	September 2001
Investigation of metal attachment to polystyrenes in matrix-assisted laser desorption ionization Rashidezadeh, H.; Guo, Baochuan Journal of the American Society for Mass Spectrometry, Vol. 9, Issue 7 https://doi.org/10.1016/S1044-0305(98)00038-5	journal	July 1998
CHCA-modified Au nanoparticles for laser desorption ionization mass spectrometric analysis of peptides Duan, Jicheng; Linman, Matthew J.; Chen, Chih-Yuan Journal of the American Society for Mass Spectrometry, Vol. 20, Issue 8 https://doi.org/10.1016/j.jasms.2009.04.009	journal	August 2009
Nanomaterial-based surface-assisted laser desorption/ionization mass spectrometry of peptides and proteins Chiang, Cheng-Kang; Chiang, Mi-Chen; Lin, Zong-Hong Journal of the American Society for Mass Spectrometry, Vol. 21, Issue 7 https://doi.org/10.1016/j.jasms.2010.02.028	journal	July 2010
Role of carbon nano-materials in the analysis of biological materials by laser desorption/ionization-mass spectrometry Najam-ul-Haq, M.; Rainer, M.; Szabó, Z. Journal of Biochemical and Biophysical Methods, Vol. 70, Issue 2 https://doi.org/10.1016/j.jbbm.2006.11.004	journal	March 2007
Nanodiamond MALDI support for enhancing the credibility of identifying proteins Wei, Li-Ming; Xue, Yan; Zhou, Xin-Wen Talanta, Vol. 74, Issue 5 https://doi.org/10.1016/j.talanta.2007.09.020	journal	February 2008
Nanomaterial-based miniaturized extraction and preconcentration techniques coupled to matrix-assisted laser desorption/ionization mass spectrometry for assaying biomolecules Kailasa, Suresh Kumar; Wu, Hui-Fen TrAC Trends in Analytical Chemistry, Vol. 65 https://doi.org/10.1016/j.trac.2014.09.011	journal	February 2015
High-Affinity Capture of Proteins by Diamond Nanoparticles for Mass Spectrometric Analysis Kong, X. L.; Huang, L. C. L.; Hsu, C. -M. Analytical Chemistry, Vol. 77, Issue 1 https://doi.org/10.1021/ac048971a	journal	January 2005
Nile Red-Adsorbed Gold Nanoparticle Matrixes for Determining Aminothiols through Surface-Assisted Laser Desorption/Ionization Mass Spectrometry Huang, Yu-Fen; Chang, Huan-Tsung Analytical Chemistry, Vol. 78, Issue 5 https://doi.org/10.1021/ac0517646	journal	March 2006
Colloidal Graphite-Assisted Laser Desorption/Ionization Mass Spectrometry and MSⁿ of Small Molecules. 1. Imaging of Cerebrosides Directly from Rat Brain Tissue Cha, Sangwon; Yeung, Edward S. Analytical Chemistry, Vol. 79, Issue 6, p. 2373-2385 https://doi.org/10.1021/ac062251h	journal	March 2007
Analysis of Adenosine Triphosphate and Glutathione through Gold Nanoparticles Assisted Laser Desorption/Ionization Mass Spectrometry Huang, Yu-Fen; Chang, Huan-Tsung Analytical Chemistry, Vol. 79, Issue 13 https://doi.org/10.1021/ac070023x	journal	July 2007
Detection of Proteins and Protein−Ligand Complexes Using HgTe Nanostructure Matrixes in Surface-Assisted Laser Desorption/Ionization Mass Spectrometry Chiang, Cheng-Kang; Yang, Zusing; Lin, Yang-Wei Analytical Chemistry, Vol. 82, Issue 11 https://doi.org/10.1021/ac100550c	journal	May 2010
Method for Simultaneous Imaging of Endogenous Low Molecular Weight Metabolites in Mouse Brain Using TiO ₂ Nanoparticles in Nanoparticle-Assisted Laser Desorption/Ionization-Imaging Mass Spectrometry Shrivas, Kamlesh; Hayasaka, Takahiro; Sugiura, Yuki Analytical Chemistry, Vol. 83, Issue 19 https://doi.org/10.1021/ac201602s	journal	October 2011
Sublimation of New Matrix Candidates for High Spatial Resolution Imaging Mass Spectrometry of Lipids: Enhanced Information in Both Positive and Negative Polarities after 1,5-Diaminonapthalene Deposition Thomas, Aurélien; Charbonneau, Jade Laveaux; Fournaise, Erik Analytical Chemistry, Vol. 84, Issue 4 https://doi.org/10.1021/ac2033547	journal	January 2012
Determination of the Intracellular Stability of Gold Nanoparticle Monolayers Using Mass Spectrometry Zhu, Zheng-Jiang; Tang, Rui; Yeh, Yi-Cheun Analytical Chemistry, Vol. 84, Issue 10 https://doi.org/10.1021/ac203408v	journal	April 2012
LDI-MS Assisted by Chemical-Free Gold Nanoparticles: Enhanced Sensitivity and Reduced Background in the Low-Mass Region Amendola, Vincenzo; Litti, Lucio; Meneghetti, Moreno Analytical Chemistry, Vol. 85, Issue 24 https://doi.org/10.1021/ac401662r	journal	November 2013
MALDI MS In-Source Decay of Glycans Using a Glutathione-Capped Iron Oxide Nanoparticle Matrix Liang, Qiaoli; Macher, Thomas; Xu, Yaolin Analytical Chemistry, Vol. 86, Issue 16 https://doi.org/10.1021/ac502422a	journal	July 2014
Nanoparticle-Assisted Laser Desorption/Ionization Based Mass Imaging with Cellular Resolution Taira, Shu; Sugiura, Yuki; Moritake, Shinji Analytical Chemistry, Vol. 80, Issue 12 https://doi.org/10.1021/ac800081z	journal	May 2008
Silver Nanoparticles as Selective Ionization Probes for Analysis of Olefins by Mass Spectrometry Sherrod, Stacy D.; Diaz, Arnaldo J.; Russell, William K. Analytical Chemistry, Vol. 80, Issue 17 https://doi.org/10.1021/ac800904g	journal	September 2008
Ion Desorption Efficiency and Internal Energy Transfer in Carbon-Based Surface-Assisted Laser Desorption/Ionization Mass Spectrometry: Desorption Mechanism(s) and the Design of SALDI Substrates Tang, Ho-Wai; Ng, Kwan-Ming; Lu, Wei Analytical Chemistry, Vol. 81, Issue 12 https://doi.org/10.1021/ac8026367	journal	May 2009
Laser Desorption/Ionization Mass Spectrometry of Peptides and Proteins with Particle Suspension Matrixes Schürenberg, Martin; Dreisewerd, Klaus; Hillenkamp, Franz Analytical Chemistry, Vol. 71, Issue 1 https://doi.org/10.1021/ac980634c	journal	January 1999
Investigation of the Chemical Interface in the Soybean–Aphid and Rice–Bacteria Interactions Using MALDI-Mass Spectrometry Imaging Klein, Adam T.; Yagnik, Gargey B.; Hohenstein, Jessica D. Analytical Chemistry, Vol. 87, Issue 10 https://doi.org/10.1021/acs.analchem.5b00459	journal	May 2015
Multiplexed Imaging of Nanoparticles in Tissues Using Laser Desorption/Ionization Mass Spectrometry Yan, Bo; Kim, Sung Tae; Kim, Chang Soo Journal of the American Chemical Society, Vol. 135, Issue 34 https://doi.org/10.1021/ja406553f	journal	August 2013
Platinum Nanoflowers for Surface-Assisted Laser Desorption/Ionization Mass Spectrometry of Biomolecules Kawasaki, Hideya; Yonezawa, Tetsu; Watanabe, Takehiro The Journal of Physical Chemistry C, Vol. 111, Issue 44 https://doi.org/10.1021/jp075159d	journal	November 2007
Tailoring Nanoparticle Surface Chemistry to Enhance Laser Desorption Ionization of Peptides and Proteins Castellana, Edward T.; Russell, David H. Nano Letters, Vol. 7, Issue 10 https://doi.org/10.1021/nl071469w	journal	October 2007
Synergistic Effect of Graphene Oxide/MWCNT Films in Laser Desorption/Ionization Mass Spectrometry of Small Molecules and Tissue Imaging Kim, Young-Kwan; Na, Hee-Kyung; Kwack, Sul-Jin ACS Nano, Vol. 5, Issue 6 https://doi.org/10.1021/nn200245v	journal	May 2011
Clathrate nanostructures for mass spectrometry Northen, Trent R.; Yanes, Oscar; Northen, Michael T. Nature, Vol. 449, Issue 7165 https://doi.org/10.1038/nature06195	journal	October 2007
Comprehensive bioimaging with fluorinated nanoparticles using breathable liquids Kurczy, Michael E.; Zhu, Zheng-Jiang; Ivanisevic, Julijana Nature Communications, Vol. 6, Issue 1 https://doi.org/10.1038/ncomms6998	journal	January 2015
Nanoparticle-based mass spectrometry for the analysis of biomolecules Chiang, Cheng-Kang; Chen, Wen-Tsen; Chang, Huan-Tsung Chem. Soc. Rev., Vol. 40, Issue 3 https://doi.org/10.1039/C0CS00050G	journal	January 2011
ZnO nanoparticle-modified polymethyl methacrylate-assisted dispersive liquid–liquid microextraction coupled with MALDI-MS for rapid pathogenic bacteria analysis Gedda, Gangaraju; Abdelhamid, Hani Nasser; Khan, M. Shahnawaz RSC Adv., Vol. 4, Issue 86 https://doi.org/10.1039/C4RA03391D	journal	January 2014
Silver nanostructures in laser desorption/ionization mass spectrometry and mass spectrometry imaging Sekuła, Justyna; Nizioł, Joanna; Rode, Wojciech The Analyst, Vol. 140, Issue 18 https://doi.org/10.1039/C5AN00943J	journal	January 2015
Multi-matrix, dual polarity, tandem mass spectrometry imaging strategy applied to a germinated maize seed: toward mass spectrometry imaging of an untargeted metabolome Feenstra, Adam D.; Hansen, Rebecca L.; Lee, Young Jin The Analyst, Vol. 140, Issue 21 https://doi.org/10.1039/C5AN01079A	journal	January 2015
Solvothermal synthesis of perovskites and pyrochlores: crystallisation of functional oxides under mild conditions Modeshia, Deena R.; Walton, Richard I. Chemical Society Reviews, Vol. 39, Issue 11 https://doi.org/10.1039/b904702f	journal	January 2010
Interference free detection for small molecules: Probing the Mn2+-doped effect and cysteine capped effect on the ZnS nanoparticles for coccidiostats and peptide analysis in SALDI-TOF MS Kailasa, Suresh Kumar; Wu, Hui-Fen The Analyst, Vol. 135, Issue 5 https://doi.org/10.1039/b919359f	journal	January 2010
Electronic and optical properties of boron-doped nanocrystalline diamond films Gajewski, W.; Achatz, P.; Williams, O. A. Physical Review B, Vol. 79, Issue 4 https://doi.org/10.1103/PhysRevB.79.045206	journal	January 2009
A rapid separation technique for overcoming suppression of triacylglycerols by phosphatidylcholine using MALDI-TOF MS Emerson, Beth; Gidden, Jennifer; Lay, Jackson O. Journal of Lipid Research, Vol. 51, Issue 8 https://doi.org/10.1194/jlr.D003798	journal	May 2010
Detailed Investigation on the Possibility of Nanoparticles of Various Metal Elements for Surface-Assisted Laser Desorption/Ionization Mass Spectrometry Yonezawa, Tetsu; Kawasaki, Hideya; Tarui, Akira Analytical Sciences, Vol. 25, Issue 3 https://doi.org/10.2116/analsci.25.339	journal	January 2009

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