Large scale nanoparticle screening for small molecule analysis in laser desorption ionization mass spectrometry

Yagnik, Gargey B.; Hansen, Rebecca L.; Korte, Andrew R.; Reichert, Malinda D.; Vela, Javier; Lee, Young Jin

doi:10.1021/acs.analchem.6b02732

Title: Large scale nanoparticle screening for small molecule analysis in laser desorption ionization mass spectrometry

Journal Article · Tue Aug 30 04:00:00 UTC 2016 · Analytical Chemistry

DOI: https://doi.org/10.1021/acs.analchem.6b02732 · OSTI ID:1337675

Yagnik, Gargey B. ^[1]; Hansen, Rebecca L. ^[1]; Korte, Andrew R. ^[1]; Reichert, Malinda D. ^[2]; Vela, Javier ^[1]; Lee, Young Jin ^[1]

Iowa State Univ., Ames, IA (United States); Ames Lab., Ames, IA (United States)
Iowa State Univ., Ames, IA (United States)

Nanoparticles (NPs) have been suggested as efficient matrixes for small molecule profiling and imaging by laser-desorption ionization mass spectrometry (LDI-MS), but so far there has been no systematic study comparing different NPs in the analysis of various classes of small molecules. Here, we present a large scale screening of 13 NPs for the analysis of two dozen small metabolite molecules. Many NPs showed much higher LDI efficiency than organic matrixes in positive mode and some NPs showed comparable efficiencies for selected analytes in negative mode. Our results suggest that a thermally driven desorption process is a key factor for metal oxide NPs, but chemical interactions are also very important, especially for other NPs. Furthermore, the screening results provide a useful guideline for the selection of NPs in the LDI-MS analysis of small molecules.

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Research Organization:: Ames Laboratory (AMES), Ames, IA (United States)

Sponsoring Organization:: USDOE Office of Science (SC), Basic Energy Sciences (BES) (SC-22)

Grant/Contract Number:: AC02-07CH11358

OSTI ID:: 1337675

Report Number(s):: IS-J--8992

Journal Information:: Analytical Chemistry, Journal Name: Analytical Chemistry Journal Issue: 18 Vol. 88; ISSN 0003-2700

Publisher:: American Chemical Society (ACS)Copyright Statement

Country of Publication:: United States

Language:: English

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