Multiplicity of morphologies in poly (L-lactide) bioresorbable vascular scaffolds
Abstract
Poly(L-lactide) (PLLA) is the structural material of the first clinically approved bioresorbable vascular scaffold (BVS), a promising alternative to permanent metal stents for treatment of coronary heart disease. BVSs are transient implants that support the occluded artery for 6 mo and are completely resorbed in 2 y. Clinical trials of BVSs report restoration of arterial vasomotion and elimination of serious complications such as late stent thrombosis. It is remarkable that a scaffold made from PLLA, known as a brittle polymer, does not fracture when crimped onto a balloon catheter or during deployment in the artery. We used X-ray microdiffraction to discover how PLLA acquired ductile character and found that the crimping process creates localized regions of extreme anisotropy; PLLA chains in the scaffold change orientation from the hoop direction to the radial direction on micrometer-scale distances. This multiplicity of morphologies in the crimped scaffold works in tandem to enable a low-stress response during deployment, which avoids fracture of the PLLA hoops and leaves them with the strength needed to support the artery. Furthermore, the transformations of the semicrystalline PLLA microstructure during crimping explain the unexpected strength and ductility of the current BVS and point the way to thinner resorbable scaffoldsmore »
- Authors:
-
- California Inst. of Technology (CalTech), Pasadena, CA (United States)
- Abbott Vascular, Santa Clara, CA (United States)
- Publication Date:
- Research Org.:
- Argonne National Laboratory (ANL), Argonne, IL (United States)
- Sponsoring Org.:
- USDOE Office of Science (SC), Basic Energy Sciences (BES). Scientific User Facilities Division
- OSTI Identifier:
- 1331703
- Grant/Contract Number:
- AC02-06CH11357; AC02-05CH1123
- Resource Type:
- Accepted Manuscript
- Journal Name:
- Proceedings of the National Academy of Sciences of the United States of America
- Additional Journal Information:
- Journal Volume: 113; Journal Issue: 42; Journal ID: ISSN 0027-8424
- Publisher:
- National Academy of Sciences
- Country of Publication:
- United States
- Language:
- ENGLISH
- Subject:
- 59 BASIC BIOLOGICAL SCIENCES; structural transformation; ductility; poly (l-lactide); coronary heart disease; microdiffraction
Citation Formats
Ailianou, Artemis, Ramachandran, Karthik, Kossuth, Mary Beth, Oberhauser, James Paul, and Kornfield, Julia A. Multiplicity of morphologies in poly (L-lactide) bioresorbable vascular scaffolds. United States: N. p., 2016.
Web. doi:10.1073/pnas.1602311113.
Ailianou, Artemis, Ramachandran, Karthik, Kossuth, Mary Beth, Oberhauser, James Paul, & Kornfield, Julia A. Multiplicity of morphologies in poly (L-lactide) bioresorbable vascular scaffolds. United States. https://doi.org/10.1073/pnas.1602311113
Ailianou, Artemis, Ramachandran, Karthik, Kossuth, Mary Beth, Oberhauser, James Paul, and Kornfield, Julia A. Mon .
"Multiplicity of morphologies in poly (L-lactide) bioresorbable vascular scaffolds". United States. https://doi.org/10.1073/pnas.1602311113. https://www.osti.gov/servlets/purl/1331703.
@article{osti_1331703,
title = {Multiplicity of morphologies in poly (L-lactide) bioresorbable vascular scaffolds},
author = {Ailianou, Artemis and Ramachandran, Karthik and Kossuth, Mary Beth and Oberhauser, James Paul and Kornfield, Julia A.},
abstractNote = {Poly(L-lactide) (PLLA) is the structural material of the first clinically approved bioresorbable vascular scaffold (BVS), a promising alternative to permanent metal stents for treatment of coronary heart disease. BVSs are transient implants that support the occluded artery for 6 mo and are completely resorbed in 2 y. Clinical trials of BVSs report restoration of arterial vasomotion and elimination of serious complications such as late stent thrombosis. It is remarkable that a scaffold made from PLLA, known as a brittle polymer, does not fracture when crimped onto a balloon catheter or during deployment in the artery. We used X-ray microdiffraction to discover how PLLA acquired ductile character and found that the crimping process creates localized regions of extreme anisotropy; PLLA chains in the scaffold change orientation from the hoop direction to the radial direction on micrometer-scale distances. This multiplicity of morphologies in the crimped scaffold works in tandem to enable a low-stress response during deployment, which avoids fracture of the PLLA hoops and leaves them with the strength needed to support the artery. Furthermore, the transformations of the semicrystalline PLLA microstructure during crimping explain the unexpected strength and ductility of the current BVS and point the way to thinner resorbable scaffolds in the future.},
doi = {10.1073/pnas.1602311113},
journal = {Proceedings of the National Academy of Sciences of the United States of America},
number = 42,
volume = 113,
place = {United States},
year = {Mon Sep 26 00:00:00 EDT 2016},
month = {Mon Sep 26 00:00:00 EDT 2016}
}
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