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Title: Dopaminergic inputs in the dentate gyrus direct the choice of memory encoding

Rewarding experiences are often well remembered, and such memory formation is known to be dependent on dopamine modulation of the neural substrates engaged in learning and memory; however, it is unknown how and where in the brain dopamine signals bias episodic memory toward preceding rather than subsequent events. Here we found that photostimulation of channelrhodopsin-2–expressing dopaminergic fibers in the dentate gyrus induced a long-term depression of cortical inputs, diminished theta oscillations, and impaired subsequent contextual learning. Computational modeling based on this dopamine modulation indicated an asymmetric association of events occurring before and after reward in memory tasks. In subsequent behavioral experiments, preexposure to a natural reward suppressed hippocampus-dependent memory formation, with an effective time window consistent with the duration of dopamine-induced changes of dentate activity. Altogether, our results suggest a mechanism by which dopamine enables the hippocampus to encode memory with reduced interference from subsequent experience.
 [1] ;  [2] ;  [3] ;  [1] ;  [2] ;  [2] ;  [4] ;  [2] ;  [1] ;  [4] ;  [2] ;  [1]
  1. Huazhong Univ. of Science and Technology, Wuhan (China)
  2. Salk Institute for Biological Studies, La Jolla, CA (United States)
  3. Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)
  4. Chinese Academy of Sciences, Shenzhen (China)
Publication Date:
Report Number(s):
Journal ID: ISSN 0027-8424; 646387; TRN: US1700156
Grant/Contract Number:
Accepted Manuscript
Journal Name:
Proceedings of the National Academy of Sciences of the United States of America
Additional Journal Information:
Journal Volume: 113; Journal Issue: 37; Journal ID: ISSN 0027-8424
National Academy of Sciences, Washington, DC (United States)
Research Org:
Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)
Sponsoring Org:
USDOE National Nuclear Security Administration (NNSA)
Country of Publication:
United States
59 BASIC BIOLOGICAL SCIENCES; dopamine; channelrhodopsin-2; theta oscillation; temporal difference learning
OSTI Identifier: