Crystal Structures of SgcE6 and SgcC, the Two-Component Monooxygenase That Catalyzes Hydroxylation of a Carrier Protein-Tethered Substrate during the Biosynthesis of the Enediyne Antitumor Antibiotic C-1027 in Streptomyces globisporus

Chang, Chin-Yuan; Lohman, Jeremy R.; Cao, Hongnan; Tan, Kemin; Rudolf, Jeffrey D.; Ma, Ming; Xu, Weijun; Bingman, Craig A.; Yennamalli, Ragothaman M.; Bigelow, Lance; Babnigg, Gyorgy; Yan, Xiaohui; Joachimiak, Andrzej; Phillips, Jr., George N.; Shen, Ben

doi:10.1021/acs.biochem.6b00713

Title: Crystal Structures of SgcE6 and SgcC, the Two-Component Monooxygenase That Catalyzes Hydroxylation of a Carrier Protein-Tethered Substrate during the Biosynthesis of the Enediyne Antitumor Antibiotic C-1027 in Streptomyces globisporus

Journal Article · Thu Sep 01 04:00:00 UTC 2016 · Biochemistry

DOI: https://doi.org/10.1021/acs.biochem.6b00713 · OSTI ID:1324326

Chang, Chin-Yuan ^[1]; Lohman, Jeremy R. ^[1]; Cao, Hongnan ^[2]; Tan, Kemin ^[3]; Rudolf, Jeffrey D. ^[1]; Ma, Ming ^[1]; Xu, Weijun ^[2]; Bingman, Craig A. ^[4]; Yennamalli, Ragothaman M. ^[5]; Bigelow, Lance ^[3]; Babnigg, Gyorgy ^[3]; Yan, Xiaohui ^[1]; Joachimiak, Andrzej ^[3]; Phillips, Jr., George N. ^[2]; Shen, Ben ^[1]

Department of Chemistry, The Scripps Research Institute, Jupiter, Florida 33458, United States
BioScience at Rice and Department of Chemistry, Rice University, Houston, Texas 77251, United States
Midwest Center for Structural Genomics and Structural Biology Center, Biosciences Division, Argonne National Laboratory, Argonne, Illinois 60439, United States
Department of Biochemistry, University of Wisconsin—Madison, Madison, Wisconsin 53705, United States
BioScience at Rice and Department of Chemistry, Rice University, Houston, Texas 77251, United States, Department of Biotechnology and Bioinformatics, Jaypee University of Information Technology, Waknaghat, Himachal Pradesh, India 173234

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Sponsoring Organization:: USDOE

Grant/Contract Number:: AC02-06CH11357

OSTI ID:: 1324326

Journal Information:: Biochemistry, Journal Name: Biochemistry Journal Issue: 36 Vol. 55; ISSN 0006-2960

Publisher:: American Chemical SocietyCopyright Statement

Country of Publication:: United States

Language:: English

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