skip to main content

DOE PAGESDOE PAGES

Title: Molecular clock of HIV-1 envelope genes under early immune selection

Here, the molecular clock hypothesis that genes or proteins evolve at a constant rate is a key tool to reveal phylogenetic relationships among species. Using the molecular clock, we can trace an infection back to transmission using HIV-1 sequences from a single time point. Whether or not a strict molecular clock applies to HIV-1’s early evolution in the presence of immune selection has not yet been fully examined.
Authors:
 [1] ;  [2] ;  [3] ;  [1] ;  [1]
  1. Univ. of Southern California, Los Angeles, CA (United States)
  2. Univ. of Rochester, Rochester, NY (United States)
  3. Los Alamos National Lab. (LANL), Los Alamos, NM (United States)
Publication Date:
OSTI Identifier:
1321764
Report Number(s):
LA-UR--15-25156
Journal ID: ISSN 1742-4690
Grant/Contract Number:
AC52-06NA25396
Type:
Accepted Manuscript
Journal Name:
Retrovirology
Additional Journal Information:
Journal Volume: 13; Journal Issue: 1; Journal ID: ISSN 1742-4690
Publisher:
BioMed Central
Research Org:
Los Alamos National Lab. (LANL), Los Alamos, NM (United States)
Sponsoring Org:
WFO; USDOE
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES biological science; HIV-1; envelope gene; molecular clock; mathematical model