Specificity and Heterogeneity of Terahertz Radiation Effect on Gene Expression in Mouse Mesenchymal Stem Cells

Alexandrov, Boian S.; Phipps, M. Lisa; Alexandrov, Ludmil B.; Booshehri, Layla G.; Erat, Anna; Zabolotny, Janice; Mielke, Charles H.; Chen, Hou-Tong; Rodriguez, George; Rasmussen, Kim O.; Martinez, Jennifer S.; Bishop, Alan R.; Usheva, Anny

doi:10.1038/srep01184

Title: Specificity and Heterogeneity of Terahertz Radiation Effect on Gene Expression in Mouse Mesenchymal Stem Cells

Journal Article · Wed Jan 30 23:00:00 EST 2013 · Scientific Reports

DOI: https://doi.org/10.1038/srep01184 · OSTI ID:1321721

Alexandrov, Boian S. ^[1]; Phipps, M. Lisa ^[2]; Alexandrov, Ludmil B. ^[3]; Booshehri, Layla G. ^[4]; Erat, Anna ^[5]; Zabolotny, Janice ^[6]; Mielke, Charles H. ^[4]; Chen, Hou-Tong ^[2]; Rodriguez, George ^[2]; Rasmussen, Kim O. ^[7]; Martinez, Jennifer S. ^[2]; Bishop, Alan R. ^[7]; Usheva, Anny ^[6]

Los Alamos National Lab. (LANL), Los Alamos, NM (United States). Theoretical Division; Harvard Medical School, Boston, MA (United States). Beth Israel Deaconess Medical Center. Dept. of Medicine
Los Alamos National Lab. (LANL), Los Alamos, NM (United States). Center for Integrated Nanotechnologies
Wellcome Trust Sanger Inst., Cambridge (United Kingdom). Cancer Genome Project
Los Alamos National Lab. (LANL), Los Alamos, NM (United States). Materials Physics and Applications Division. National High Magnetic Field Lab. (NHMFL)
Harvard Medical School, Boston, MA (United States). Beth Israel Deaconess Medical Center. Dept. of Medicine; Univ. Hospital Zurich (Switzerland). Research Unit of the Division of Internal Medicine
Harvard Medical School, Boston, MA (United States). Beth Israel Deaconess Medical Center. Dept. of Medicine
Los Alamos National Lab. (LANL), Los Alamos, NM (United States). Theoretical Division

In this paper, we report that terahertz (THz) irradiation of mouse mesenchymal stem cells (mMSCs) with a single-frequency (SF) 2.52 THz laser or pulsed broadband (centered at 10 THz) source results in irradiation specific heterogenic changes in gene expression. The THz effect depends on irradiation parameters such as the duration and type of THz source, and on the degree of stem cell differentiation. Our microarray survey and RT-PCR experiments demonstrate that prolonged broadband THz irradiation drives mMSCs toward differentiation, while 2-hour irradiation (regardless of THz sources) affects genes transcriptionally active in pluripotent stem cells. The strictly controlled experimental environment indicates minimal temperature changes and the absence of any discernable response to heat shock and cellular stress genes imply a non-thermal response. Computer simulations of the core promoters of two pluripotency markers reveal association between gene upregulation and propensity for DNA breathing. Finally, we propose that THz radiation has potential for non-contact control of cellular gene expression.

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Research Organization:: Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Harvard Medical School, Boston, MA (United States)

Sponsoring Organization:: USDOE Office of Science (SC), Basic Energy Sciences (BES) (SC-22)

Grant/Contract Number:: AC52-06NA25396; AC04-94AL85000

OSTI ID:: 1321721

Report Number(s):: LA-UR--12-24696

Journal Information:: Scientific Reports, Journal Name: Scientific Reports Vol. 3; ISSN 2045-2322

Publisher:: Nature Publishing GroupCopyright Statement

Country of Publication:: United States

Language:: English

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Title: Specificity and Heterogeneity of Terahertz Radiation Effect on Gene Expression in Mouse Mesenchymal Stem Cells

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