Compensatory islet response to insulin resistance revealed by quantitative proteomics
Abstract
Compensatory islet response is a distinct feature of the pre-diabetic insulin resistant state in humans and rodents. To identify alterations in the islet proteome that characterize the adaptive response, we analyzed islets from five-month-old male control, high-fat diet fed (HFD) or obese ob/ob mice by LC-MS(/MS) and quantified ~1,100 islet proteins (at least two peptides) with a false discovery rate <1%. Significant alterations in abundance were observed for ~350 proteins between groups. A majority of alterations were common to both models, and the changes of a subset of ~40 proteins and 12 proteins were verified by targeted quantification using selected reaction monitoring and Western blots, respectively. The insulin resistant islets in both groups exhibited reduced expression of proteins controlling energy metabolism, oxidative phosphorylation, hormone processing, and secretory pathways. Conversely, an increased expression of molecules involved in protein synthesis and folding suggested effects in endoplasmic reticulum stress response, cell survival, and proliferation in both insulin resistant models. In conclusion, we report a unique comparison of the islet proteome that is focused on the compensatory response in two insulin resistant rodent models that are not overtly diabetic. In conclusion, these data provide a valuable resource of candidate proteins to the scientific communitymore »
- Authors:
-
- Brigham and Women's Hospital (Harvard Medical School), Boston, MA (United States). Joslin Diabetes Center
- Pacific Northwest National Lab. (PNNL), Richland, WA (United States). Biological Sciences Division, and Environmental Molecular Sciences Lab. (EMSL)
- Univ. of Illinois at Chicago, Chicago, IL (United States). Dept. of Physiology and Biophysics
- Publication Date:
- Research Org.:
- Pacific Northwest National Laboratory (PNNL), Richland, WA (United States)
- Sponsoring Org.:
- USDOE Office of Science (SC), Biological and Environmental Research (BER)
- OSTI Identifier:
- 1287492
- Grant/Contract Number:
- AC05-76RLO1830; 3-APF-2014-182-A-N; K99 DK090210; R01 DK067536; R01 DK074795; R01 DK103215
- Resource Type:
- Accepted Manuscript
- Journal Name:
- Journal of Proteome Research
- Additional Journal Information:
- Journal Volume: 14; Journal Issue: 8; Journal ID: ISSN 1535-3893
- Publisher:
- American Chemical Society (ACS)
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 59 BASIC BIOLOGICAL SCIENCES; 60 APPLIED LIFE SCIENCES; insulin resistance; pancreatic islets; proteome; proliferation; metabolism; function
Citation Formats
El Ouaamari, Abdelfattah, Zhou, Jian -Ying, Liew, Chong Wee, Shirakawa, Jun, Dirice, Ercument, Gedeon, Nicholas, Kahraman, Sevim, De Jesus, Dario F., Bhatt, Shweta, Kim, Jong -Seo, Clauss, Therese R. W., Camp, II, David G., Smith, Richard D., Qian, Wei -Jun, and Kulkarni, Rohit N. Compensatory islet response to insulin resistance revealed by quantitative proteomics. United States: N. p., 2015.
Web. doi:10.1021/acs.jproteome.5b00587.
El Ouaamari, Abdelfattah, Zhou, Jian -Ying, Liew, Chong Wee, Shirakawa, Jun, Dirice, Ercument, Gedeon, Nicholas, Kahraman, Sevim, De Jesus, Dario F., Bhatt, Shweta, Kim, Jong -Seo, Clauss, Therese R. W., Camp, II, David G., Smith, Richard D., Qian, Wei -Jun, & Kulkarni, Rohit N. Compensatory islet response to insulin resistance revealed by quantitative proteomics. United States. https://doi.org/10.1021/acs.jproteome.5b00587
El Ouaamari, Abdelfattah, Zhou, Jian -Ying, Liew, Chong Wee, Shirakawa, Jun, Dirice, Ercument, Gedeon, Nicholas, Kahraman, Sevim, De Jesus, Dario F., Bhatt, Shweta, Kim, Jong -Seo, Clauss, Therese R. W., Camp, II, David G., Smith, Richard D., Qian, Wei -Jun, and Kulkarni, Rohit N. Tue .
"Compensatory islet response to insulin resistance revealed by quantitative proteomics". United States. https://doi.org/10.1021/acs.jproteome.5b00587. https://www.osti.gov/servlets/purl/1287492.
@article{osti_1287492,
title = {Compensatory islet response to insulin resistance revealed by quantitative proteomics},
author = {El Ouaamari, Abdelfattah and Zhou, Jian -Ying and Liew, Chong Wee and Shirakawa, Jun and Dirice, Ercument and Gedeon, Nicholas and Kahraman, Sevim and De Jesus, Dario F. and Bhatt, Shweta and Kim, Jong -Seo and Clauss, Therese R. W. and Camp, II, David G. and Smith, Richard D. and Qian, Wei -Jun and Kulkarni, Rohit N.},
abstractNote = {Compensatory islet response is a distinct feature of the pre-diabetic insulin resistant state in humans and rodents. To identify alterations in the islet proteome that characterize the adaptive response, we analyzed islets from five-month-old male control, high-fat diet fed (HFD) or obese ob/ob mice by LC-MS(/MS) and quantified ~1,100 islet proteins (at least two peptides) with a false discovery rate <1%. Significant alterations in abundance were observed for ~350 proteins between groups. A majority of alterations were common to both models, and the changes of a subset of ~40 proteins and 12 proteins were verified by targeted quantification using selected reaction monitoring and Western blots, respectively. The insulin resistant islets in both groups exhibited reduced expression of proteins controlling energy metabolism, oxidative phosphorylation, hormone processing, and secretory pathways. Conversely, an increased expression of molecules involved in protein synthesis and folding suggested effects in endoplasmic reticulum stress response, cell survival, and proliferation in both insulin resistant models. In conclusion, we report a unique comparison of the islet proteome that is focused on the compensatory response in two insulin resistant rodent models that are not overtly diabetic. In conclusion, these data provide a valuable resource of candidate proteins to the scientific community to undertake further studies aimed at enhancing β-cell mass in patients with diabetes. The data are available via the MassIVE repository, with accession MSV000079093.},
doi = {10.1021/acs.jproteome.5b00587},
journal = {Journal of Proteome Research},
number = 8,
volume = 14,
place = {United States},
year = {Tue Jul 07 00:00:00 EDT 2015},
month = {Tue Jul 07 00:00:00 EDT 2015}
}
Web of Science
Works referenced in this record:
Global Prevalence of Diabetes: Estimates for the year 2000 and projections for 2030
journal, April 2004
- Wild, S.; Roglic, G.; Green, A.
- Diabetes Care, Vol. 27, Issue 5
The Emerging Genetic Architecture of Type 2 Diabetes
journal, September 2008
- Doria, Alessandro; Patti, Mary-Elizabeth; Kahn, C. Ronald
- Cell Metabolism, Vol. 8, Issue 3
Chronic high glucose induced INS-1β cell mitochondrial dysfunction: A comparative mitochondrial proteome with SILAC
journal, October 2013
- Chen, Xiulan; Cui, Ziyou; Wei, Shasha
- PROTEOMICS, Vol. 13, Issue 20
Five Stages of Evolving Beta-Cell Dysfunction During Progression to Diabetes
journal, November 2004
- Weir, G. C.; Bonner-Weir, S.
- Diabetes, Vol. 53, Issue Supplement 3
Differentially Expressed Proteins in the Pancreas of Diet-induced Diabetic Mice
journal, September 2005
- Qiu, Linghua; List, Edward O.; Kopchick, John J.
- Molecular & Cellular Proteomics, Vol. 4, Issue 9
SH2B1 in -Cells Regulates Glucose Metabolism by Promoting -Cell Survival and Islet Expansion
journal, October 2013
- Chen, Z.; Morris, D. L.; Jiang, L.
- Diabetes, Vol. 63, Issue 2
Target-decoy search strategy for increased confidence in large-scale protein identifications by mass spectrometry
journal, February 2007
- Elias, Joshua E.; Gygi, Steven P.
- Nature Methods, Vol. 4, Issue 3
DAnTE: a statistical tool for quantitative analysis of -omics data
journal, May 2008
- Polpitiya, A. D.; Qian, W. -J.; Jaitly, N.
- Bioinformatics, Vol. 24, Issue 13
Haploid Insufficiency of Suppressor Enhancer Lin12 1-like (SEL1L) Protein Predisposes Mice to High Fat Diet-induced Hyperglycemia
journal, June 2011
- Francisco, Adam B.; Singh, Rajni; Sha, Haibo
- Journal of Biological Chemistry, Vol. 286, Issue 25
Nucleobindin-2 Is a Positive Modulator of EGF-Dependent Signals Leading to Enhancement of Cell Growth and Suppression of Adipocyte Differentiation
journal, April 2012
- Tagaya, Yuko; Miura, Atsuko; Okada, Shuichi
- Endocrinology, Vol. 153, Issue 7
A Simple Procedure for Effective Quenching of Trypsin Activity and Prevention of 18 O-Labeling Back-Exchange
journal, March 2009
- Petritis, Brianne O.; Qian, Wei-Jun; Camp, David G.
- Journal of Proteome Research, Vol. 8, Issue 5
Metabolic Diapause in Pancreatic β-Cells Expressing a Gain-of-function Mutant of the Forkhead Protein Foxo1
journal, January 2007
- Buteau, Jean; Shlien, Adam; Foisy, Sylvain
- Journal of Biological Chemistry, Vol. 282, Issue 1
Small human islets comprised of more β -cells with higher insulin content than large islets
journal, March 2013
- Farhat, Bilal; Almelkar, Akshay; Ramachandran, Karthik
- Islets, Vol. 5, Issue 2
β-Cell deterioration during diabetes: what's in the gun?
journal, October 2009
- Robertson, R. Paul
- Trends in Endocrinology & Metabolism, Vol. 20, Issue 8
Tissue-Specific Knockout of the Insulin Receptor in Pancreatic β Cells Creates an Insulin Secretory Defect Similar to that in Type 2 Diabetes
journal, February 1999
- Kulkarni, Rohit N.; Brüning, Jens C.; Winnay, Jonathon N.
- Cell, Vol. 96, Issue 3
Improved LC−MS/MS Spectral Counting Statistics by Recovering Low-Scoring Spectra Matched to Confidently Identified Peptide Sequences
journal, November 2010
- Zhou, Jian-Ying; Schepmoes, Athena A.; Zhang, Xu
- Journal of Proteome Research, Vol. 9, Issue 11
Preservation of β-cell function by targeting β-cell mass
journal, April 2008
- Dekoning, E.; Bonnerweir, S.; Rabelink, T.
- Trends in Pharmacological Sciences, Vol. 29, Issue 4
Loss of Insulin Signaling in Hepatocytes Leads to Severe Insulin Resistance and Progressive Hepatic Dysfunction
journal, July 2000
- Michael, M. Dodson; Kulkarni, Rohit N.; Postic, Catherine
- Molecular Cell, Vol. 6, Issue 1
Urocortin 3 Marks Mature Human Primary and Embryonic Stem Cell-Derived Pancreatic Alpha and Beta Cells
journal, December 2012
- van der Meulen, Talitha; Xie, Ruiyu; Kelly, Olivia G.
- PLoS ONE, Vol. 7, Issue 12
Increased Islet Volume but Unchanged Islet Number in ob/ob Mice
journal, July 2003
- Bock, T.; Pakkenberg, B.; Buschard, K.
- Diabetes, Vol. 52, Issue 7
Proteomics Analysis of Cytokine-induced Dysfunction and Death in Insulin-producing INS-1E Cells: New Insights into the Pathways Involved
journal, October 2007
- D'Hertog, Wannes; Overbergh, Lut; Lage, Kasper
- Molecular & Cellular Proteomics, Vol. 6, Issue 12
Peroxiredoxin 6, a Novel Player in the Pathogenesis of Diabetes
journal, June 2014
- Pacifici, F.; Arriga, R.; Sorice, G. P.
- Diabetes, Vol. 63, Issue 10
Detection of Differential Proteomes Associated with the Development of Type 2 Diabetes in the Zucker Rat Model Using the iTRAQ Technique
journal, February 2011
- Han, Dohyun; Moon, Sungyoon; Kim, Hyunsoo
- Journal of Proteome Research, Vol. 10, Issue 2
International Trial of the Edmonton Protocol for Islet Transplantation
journal, September 2006
- Shapiro, A. M. James; Ricordi, Camillo; Hering, Bernhard J.
- New England Journal of Medicine, Vol. 355, Issue 13
Mechanisms of Compensatory -Cell Growth in Insulin-Resistant Rats: Roles of Akt Kinase
journal, July 2005
- Jetton, T. L.; Lausier, J.; LaRock, K.
- Diabetes, Vol. 54, Issue 8
Insulin receptors in beta-cells are critical for islet compensatory growth response to insulin resistance
journal, April 2007
- Okada, T.; Liew, C. W.; Hu, J.
- Proceedings of the National Academy of Sciences, Vol. 104, Issue 21
Modulation of the peroxiredoxin system by cytokines in insulin-producing RINm5F cells: Down-regulation of PRDX6 increases susceptibility of beta cells to oxidative stress
journal, July 2013
- Paula, Flavia M. M.; Ferreira, Sandra M.; Boschero, Antonio C.
- Molecular and Cellular Endocrinology, Vol. 374, Issue 1-2
Usefulness of CDK5RAP3, CCNB2, and RAGE genes for the diagnosis of lung adenocarcinoma
journal, January 2007
- Stav, D.; Bar, I.; Sandbank, J.
- The International Journal of Biological Markers, Vol. 22, Issue 2
18O-Labeled Proteome Reference as Global Internal Standards for Targeted Quantification by Selected Reaction Monitoring-Mass Spectrometry
journal, December 2011
- Kim, Jong-Seo; Fillmore, Thomas L.; Liu, Tao
- Molecular & Cellular Proteomics, Vol. 10, Issue 12
Mechanism of compensatory hyperinsulinemia in normoglycemic insulin-resistant spontaneously hypertensive rats. Augmented enzymatic activity of glucokinase in beta-cells.
journal, July 1994
- Chen, C.; Hosokawa, H.; Bumbalo, L. M.
- Journal of Clinical Investigation, Vol. 94, Issue 1
Nesfatin-1 stimulates glucagon and insulin secretion and beta cell NUCB2 is reduced in human type 2 diabetic subjects
journal, November 2011
- Riva, Matteo; Nitert, Marloes Dekker; Voss, Ulrikke
- Cell and Tissue Research, Vol. 346, Issue 3
Identification of nesfatin-1 as a satiety molecule in the hypothalamus
journal, October 2006
- Oh-I, Shinsuke; Shimizu, Hiroyuki; Satoh, Tetsurou
- Nature, Vol. 443, Issue 7112
Differential Proteomic Analysis of the Pancreas of Diabetic db/db Mice Reveals the Proteins Involved in the Development of Complications of Diabetes Mellitus
journal, May 2014
- Pérez-Vázquez, Victoriano; Guzmán-Flores, Juan; Mares-Álvarez, Daniela
- International Journal of Molecular Sciences, Vol. 15, Issue 6
Low insulin content of large islet population is present in situ and in isolated islets
journal, January 2011
- Huang, Han-Hung; Novikova, Lesya; Williams, S. Janette
- Islets, Vol. 3, Issue 1
Large-Scale Multiplexed Quantitative Discovery Proteomics Enabled by the Use of an 18 O-Labeled “Universal” Reference Sample
journal, January 2009
- Qian, Wei-Jun; Liu, Tao; Petyuk, Vladislav A.
- Journal of Proteome Research, Vol. 8, Issue 1
Altered function of insulin receptor substrate-1–deficient mouse islets and cultured β-cell lines
journal, December 1999
- Kulkarni, Rohit N.; Winnay, Jonathon N.; Daniels, Molly
- Journal of Clinical Investigation, Vol. 104, Issue 12
Sel1L is indispensable for mammalian endoplasmic reticulum-associated degradation, endoplasmic reticulum homeostasis, and survival
journal, January 2014
- Sun, Shengyi; Shi, Guojun; Han, Xuemei
- Proceedings of the National Academy of Sciences, Vol. 111, Issue 5
β-Cell Adaptation to Insulin Resistance
journal, October 2002
- Liu, Ye Qi; Jetton, Thomas L.; Leahy, Jack L.
- Journal of Biological Chemistry, Vol. 277, Issue 42
Adaptive β-cell proliferation increases early in high-fat feeding in mice, concurrent with metabolic changes, with induction of islet cyclin D2 expression
journal, July 2013
- Stamateris, Rachel E.; Sharma, Rohit B.; Hollern, Douglas A.
- American Journal of Physiology-Endocrinology and Metabolism, Vol. 305, Issue 1
Antibody-free PRISM–SRM for multiplexed protein quantification: is this the new competition for immunoassays in bioanalysis?
journal, February 2013
- Shi, Tujin; Qian, Wei-Jun
- Bioanalysis, Vol. 5, Issue 3
Levels of the conversion endoproteases PC1 (PC3) and PC2 distinguish between insulin-producing pancreatic islet β cells and non-β cells
journal, May 1994
- Neerman-Arbez, M.; Cirulli, V.; Halban, P. A.
- Biochemical Journal, Vol. 300, Issue 1
Pancreatic β Cell Dedifferentiation as a Mechanism of Diabetic β Cell Failure
journal, September 2012
- Talchai, Chutima; Xuan, Shouhong; Lin, Hua V.
- Cell, Vol. 150, Issue 6
Quantitative study of insulin secretion and clearance in normal and obese subjects.
journal, February 1988
- Polonsky, K. S.; Given, B. D.; Hirsch, L.
- Journal of Clinical Investigation, Vol. 81, Issue 2
Identification of the functional role of peroxiredoxin 6 in the progression of breast cancer
journal, November 2007
- Chang, Xin-Zhong; Li, Da-Qiang; Hou, Yi-Feng
- Breast Cancer Research, Vol. 9, Issue 6
Functional beta-cell maturation is marked by an increased glucose threshold and by expression of urocortin 3
journal, February 2012
- Blum, Barak; Hrvatin, Siniša; Schuetz, Christian
- Nature Biotechnology, Vol. 30, Issue 3
The Identification of Potential Factors Associated with the Development of Type 2 Diabetes
journal, August 2008
- Lu, Hongfang; Yang, Ying; Allister, Emma M.
- Molecular & Cellular Proteomics, Vol. 7, Issue 8
Advances in proteomics data analysis and display using an accurate mass and time tag approach
journal, January 2006
- Zimmer, Jennifer S. D.; Monroe, Matthew E.; Qian, Wei-Jun
- Mass Spectrometry Reviews, Vol. 25, Issue 3
Role of the Saturated Nonesterified Fatty Acid Palmitate in Beta Cell Dysfunction
journal, December 2012
- Maris, Michael; Robert, Sofie; Waelkens, Etienne
- Journal of Proteome Research, Vol. 12, Issue 1
Reduced Progression of Diabetic Microvascular Complications With Islet Cell Transplantation Compared With Intensive Medical Therapy
journal, January 2011
- Thompson, David M.; Meloche, Mark; Ao, Ziliang
- Transplantation, Vol. 91, Issue 3
Diet-Induced Obesity Causes Severe but Reversible Leptin Resistance in Arcuate Melanocortin Neurons
journal, March 2007
- Enriori, Pablo J.; Evans, Anne E.; Sinnayah, Puspha
- Cell Metabolism, Vol. 5, Issue 3
High Glucose Induces Dysfunction in Insulin Secretory Cells by Different Pathways: A Proteomic Approach
journal, December 2010
- Maris, Michael; Ferreira, Gabriela B.; D’Hertog, Wannes
- Journal of Proteome Research, Vol. 9, Issue 12
A Statistical Model for Identifying Proteins by Tandem Mass Spectrometry
journal, September 2003
- Nesvizhskii, Alexey I.; Keller, Andrew; Kolker, Eugene
- Analytical Chemistry, Vol. 75, Issue 17
Overexpression of a Novel Activator of PAK4, the CDK5 Kinase–Associated Protein CDK5RAP3, Promotes Hepatocellular Carcinoma Metastasis
journal, March 2011
- Mak, Grace Wing-Yan; Chan, Mandy Man-Lok; Leong, Veronica Yee-Law
- Cancer Research, Vol. 71, Issue 8
Dietary-fat-induced obesity in mice results in beta cell hyperplasia but not increased insulin release: evidence for specificity of impaired beta cell adaptation
journal, June 2005
- Hull, R. L.; Kodama, K.; Utzschneider, K. M.
- Diabetologia, Vol. 48, Issue 7
Development and Evaluation of a Micro- and Nanoscale Proteomic Sample Preparation Method
journal, December 2005
- Wang, Haixing; Qian, Wei-Jun; Mottaz, Heather M.
- Journal of Proteome Research, Vol. 4, Issue 6
Antibody-free, targeted mass-spectrometric approach for quantification of proteins at low picogram per milliliter levels in human plasma/serum
journal, September 2012
- Shi, T.; Fillmore, T. L.; Sun, X.
- Proceedings of the National Academy of Sciences, Vol. 109, Issue 38
Inhibition of Insulin Secretion as a New Drug Target in the Treatment of Metabolic Disorders
journal, June 2004
- Hansen, J.; G. Arkhammar, Per; Bodvarsdottir, Thora
- Current Medicinal Chemistry, Vol. 11, Issue 12
Nucleophosmin is essential for c-Myc nucleolar localization and c-Myc-mediated rDNA transcription
journal, June 2012
- Li, Z.; Hann, S. R.
- Oncogene, Vol. 32, Issue 15
Alterations in the Glucose-Stimulated Insulin Secretory Dose-Response Curve and in Insulin Clearance in Nondiabetic Insulin-Resistant Individuals
journal, June 1997
- Jones, Clare N. O.; Pei, Dee; Staris, Patricia
- The Journal of Clinical Endocrinology & Metabolism, Vol. 82, Issue 6
Heterozygous SOD2 Deletion Impairs Glucose-Stimulated Insulin Secretion, but Not Insulin Action, in High-Fat–Fed Mice
journal, June 2014
- Kang, Li; Dai, Chunhua; Lustig, Mary E.
- Diabetes, Vol. 63, Issue 11
Molecular and Metabolic Evidence for Mitochondrial Defects Associated With β-Cell Dysfunction in a Mouse Model of Type 2 Diabetes
journal, November 2009
- Lu, Hongfang; Koshkin, Vasilij; Allister, Emma M.
- Diabetes, Vol. 59, Issue 2
Septins: the fourth component of the cytoskeleton
journal, February 2012
- Mostowy, Serge; Cossart, Pascale
- Nature Reviews Molecular Cell Biology, Vol. 13, Issue 3
Growth factor control of pancreatic islet regeneration and function
journal, February 2009
- Assmann, Anke; Hinault, Charlotte; Kulkarni, Rohit N.
- Pediatric Diabetes, Vol. 10, Issue 1
Urocortin 3 regulates glucose-stimulated insulin secretion and energy homeostasis
journal, February 2007
- Li, C.; Chen, P.; Vaughan, J.
- Proceedings of the National Academy of Sciences, Vol. 104, Issue 10
Adaptation of islets of Langerhans to pregnancy: increased islet cell proliferation and insulin secretion correlates with the onset of placental lactogen secretion.
journal, March 1992
- Parsons, J. A.; Brelje, T. C.; Sorenson, R. L.
- Endocrinology, Vol. 130, Issue 3
Spectral Probabilities and Generating Functions of Tandem Mass Spectra: A Strike against Decoy Databases
journal, August 2008
- Kim, Sangtae; Gupta, Nitin; Pevzner, Pavel A.
- Journal of Proteome Research, Vol. 7, Issue 8
Mutational analysis of VAMP domains implicated in Ca2+-induced insulin exocytosis.
journal, December 1996
- Regazzi, R.; Sadoul, K.; Meda, P.
- The EMBO Journal, Vol. 15, Issue 24
A dual population of islets of Langerhans in bovine pancreas
journal, February 1980
- Bonner-Weir, S.; Like, A. A.
- Cell and Tissue Research, Vol. 206, Issue 1
Peroxiredoxin III protects pancreatic β cells from apoptosis
journal, August 2010
- Wolf, Gabriele; Aumann, Nicole; Michalska, Marta
- Journal of Endocrinology, Vol. 207, Issue 2
VIPER: an advanced software package to support high-throughput LC-MS peptide identification
journal, June 2007
- Monroe, Matthew E.; Tolić, Nikola; Jaitly, Navdeep
- Bioinformatics, Vol. 23, Issue 15
Development of a Novel Polygenic Model of NIDDM in Mice Heterozygous for IR and IRS-1 Null Alleles
journal, February 1997
- Brüning, Jens C.; Winnay, Jonathon; Bonner-Weir, Susan
- Cell, Vol. 88, Issue 4
Usefulness of CDK5RAP3, CCNB2 , and RAGE Genes for the Diagnosis of Lung Adenocarcinoma
journal, April 2007
- Stav, D.; Bar, I.; Sandbank, J.
- The International Journal of Biological Markers, Vol. 22, Issue 2
Works referencing / citing this record:
m6A mRNA methylation regulates human β-cell biology in physiological states and in type 2 diabetes
journal, July 2019
- De Jesus, Dario F.; Zhang, Zijie; Kahraman, Sevim
- Nature Metabolism, Vol. 1, Issue 8
Novel factors modulating human β-cell proliferation
journal, September 2016
- Shirakawa, J.; Kulkarni, R. N.
- Diabetes, Obesity and Metabolism, Vol. 18
In vivo phosphoproteomics reveals pathogenic signaling changes in diabetic islets
posted_content, October 2018
- Sacco, Francesca; Seelig, Anett; Humphrey, Sean J.
- Cell Metabolism
A proteomic signature that reflects pancreatic beta-cell function
journal, August 2018
- Curran, Aoife M.; Scott-Boyer, Marie Pier; Kaput, Jim
- PLOS ONE, Vol. 13, Issue 8
Differential proteomic analysis of white adipose tissues from T2D KKAy mice by LC-ESI-QTOF
journal, March 2017
- Ke, Ming; Wu, Hanyan; Zhu, Zhaoyang
- PROTEOMICS, Vol. 17, Issue 5
Forkhead box protein O1 (FoxO1) regulates hepatic serine protease inhibitor B1 (serpinB1) expression in a non-cell-autonomous fashion
journal, January 2019
- El Ouaamari, Abdelfattah; O-Sullivan, InSug; Shirakawa, Jun
- Journal of Biological Chemistry, Vol. 294, Issue 3
β Cell dysfunction during progression of metabolic syndrome to type 2 diabetes
journal, August 2019
- Hudish, Laura I.; Reusch, Jane E. B.; Sussel, Lori
- Journal of Clinical Investigation, Vol. 129, Issue 10
Imaging mass spectrometry enables molecular profiling of mouse and human pancreatic tissue
journal, April 2019
- Prentice, Boone M.; Hart, Nathaniel J.; Phillips, Neil
- Diabetologia, Vol. 62, Issue 6
m6A mRNA methylation regulates human β-cell biology in physiological states and in type 2 diabetes
journal, July 2019
- De Jesus, Dario F.; Zhang, Zijie; Kahraman, Sevim
- Nature Metabolism, Vol. 1, Issue 8