Leading-process actomyosin coordinates organelle positioning and adhesion receptor dynamics in radially migrating cerebellar granule neurons

Trivedi, Niraj; Ramahi, Joseph S.; Karakaya, Mahmut; Howell, Danielle; Kerekes, Ryan A.; Solecki, David J.

doi:10.1186/1749-8104-9-26

Title: Leading-process actomyosin coordinates organelle positioning and adhesion receptor dynamics in radially migrating cerebellar granule neurons

Journal Article · Mon Dec 01 23:00:00 EST 2014 · Neural Development

DOI: https://doi.org/10.1186/1749-8104-9-26 · OSTI ID:1286758

Trivedi, Niraj ^[1]; Ramahi, Joseph S. ^[1]; Karakaya, Mahmut ^[2]; Howell, Danielle ^[1]; Kerekes, Ryan A. ^[2]; Solecki, David J. ^[1]

St. Jude Children's Research Hospital, Memphis, TN (United States). Dept. of Developmental Neurobiology
Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)

During brain development, neurons migrate from germinal zones to their final positions to assemble neural circuits. A unique saltatory cadence involving cyclical organelle movement (e.g., centrosome motility) and leading-process actomyosin enrichment prior to nucleokinesis organizes neuronal migration. While functional evidence suggests that leading-process actomyosin is essential for centrosome motility, the role of the actin-enriched leading process in globally organizing organelle transport or traction forces remains unexplored. Our results show that myosin ii motors and F-actin dynamics are required for Golgi apparatus positioning before nucleokinesis in cerebellar granule neurons (CGNs) migrating along glial fibers. Moreover, we show that primary cilia are motile organelles, localized to the leading-process F-actin-rich domain and immobilized by pharmacological inhibition of myosin ii and F-actin dynamics. Finally, leading process adhesion dynamics are dependent on myosin ii and F-actin. In conclusion, we propose that actomyosin coordinates the overall polarity of migrating CGNs by controlling asymmetric organelle positioning and cell-cell contacts as these cells move along their glial guides.

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Research Organization:: Oak Ridge National Laboratory (ORNL), Oak Ridge, TN (United States)

Sponsoring Organization:: USDOE; ORNL work for others; American Lebanese Syrian Associated Charities (ALSAC); National Inst. of Neurological Disorders (NINDS)

Grant/Contract Number:: AC05-00OR22725

OSTI ID:: 1286758

Journal Information:: Neural Development, Journal Name: Neural Development Journal Issue: 1 Vol. 9; ISSN 1749-8104

Publisher:: BioMed CentralCopyright Statement

Country of Publication:: United States

Language:: English

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Neuron's little helper: The role of primary cilia in neurogenesis Lepanto, Paola; Badano, Jose L.; Zolessi, Flavio R. Neurogenesis, Vol. 3, Issue 1 https://doi.org/10.1080/23262133.2016.1253363	journal	January 2016
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