Overlapping patterns of brain activation to food and cocaine cues in cocaine abusers: Association to striatal D2/D3 receptors
Abstract
Cocaine, through its activation of dopamine (DA) signaling, usurps pathways that process natural rewards. However, the extent to which there is overlap between the networks that process natural and drug rewards and whether DA signaling associated with cocaine abuse influences these networks have not been investigated in humans. We measured brain activation responses to food and cocaine cues with fMRI, and D2/D3 receptors in the striatum with [11C]raclopride and PET in 20 active cocaine abusers. Compared to neutral cues, food and cocaine cues increasingly engaged cerebellum, orbitofrontal, inferior frontal and premotor cortices and insula and disengaged cuneus and default mode network (DMN). These fMRI signals were proportional to striatal D2/D3 receptors. Surprisingly cocaine and food cues also deactivated ventral striatum and hypothalamus. Compared to food cues, cocaine cues produced lower activation in insula and postcentral gyrus, and less deactivation in hypothalamus and DMN regions. Activation in cortical regions and cerebellum increased in proportion to the valence of the cues, and activation to food cues in somatosensory and orbitofrontal cortices also increased in proportion to body mass. Longer exposure to cocaine was associated with lower activation to both cues in occipital cortex and cerebellum, which could reflect the decreases in D2/D3more »
- Authors:
-
- National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD (United States)
- Brookhaven National Lab. (BNL), Upton, NY (United States)
- National Institute on Drug Abuse, Bethesda, MD (United States)
- New York Univ., New York, NY (United States)
- National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD (United States); National Institute on Drug Abuse, Bethesda, MD (United States)
- Publication Date:
- Research Org.:
- Brookhaven National Laboratory (BNL), Upton, NY (United States)
- Sponsoring Org.:
- USDOE; National Inst. of Alcohol Abuse and Alcoholism (NIAAA)
- OSTI Identifier:
- 1281081
- Grant/Contract Number:
- 2RO1AA09481
- Resource Type:
- Accepted Manuscript
- Journal Name:
- Human Brain Mapping
- Additional Journal Information:
- Journal Volume: 36; Journal Issue: 1; Journal ID: ISSN 1065-9471
- Publisher:
- Wiley
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 60 APPLIED LIFE SCIENCES; 59 BASIC BIOLOGICAL SCIENCES; reward; addiction; obesity; fMRI; PET
Citation Formats
Tomasi, Dardo, Wang, Gene -Jack, Wang, Ruiliang, Caparelli, Elisabeth C., Logan, Jean, and Volkow, Nora D. Overlapping patterns of brain activation to food and cocaine cues in cocaine abusers: Association to striatal D2/D3 receptors. United States: N. p., 2014.
Web. doi:10.1002/hbm.22617.
Tomasi, Dardo, Wang, Gene -Jack, Wang, Ruiliang, Caparelli, Elisabeth C., Logan, Jean, & Volkow, Nora D. Overlapping patterns of brain activation to food and cocaine cues in cocaine abusers: Association to striatal D2/D3 receptors. United States. https://doi.org/10.1002/hbm.22617
Tomasi, Dardo, Wang, Gene -Jack, Wang, Ruiliang, Caparelli, Elisabeth C., Logan, Jean, and Volkow, Nora D. Wed .
"Overlapping patterns of brain activation to food and cocaine cues in cocaine abusers: Association to striatal D2/D3 receptors". United States. https://doi.org/10.1002/hbm.22617. https://www.osti.gov/servlets/purl/1281081.
@article{osti_1281081,
title = {Overlapping patterns of brain activation to food and cocaine cues in cocaine abusers: Association to striatal D2/D3 receptors},
author = {Tomasi, Dardo and Wang, Gene -Jack and Wang, Ruiliang and Caparelli, Elisabeth C. and Logan, Jean and Volkow, Nora D.},
abstractNote = {Cocaine, through its activation of dopamine (DA) signaling, usurps pathways that process natural rewards. However, the extent to which there is overlap between the networks that process natural and drug rewards and whether DA signaling associated with cocaine abuse influences these networks have not been investigated in humans. We measured brain activation responses to food and cocaine cues with fMRI, and D2/D3 receptors in the striatum with [11C]raclopride and PET in 20 active cocaine abusers. Compared to neutral cues, food and cocaine cues increasingly engaged cerebellum, orbitofrontal, inferior frontal and premotor cortices and insula and disengaged cuneus and default mode network (DMN). These fMRI signals were proportional to striatal D2/D3 receptors. Surprisingly cocaine and food cues also deactivated ventral striatum and hypothalamus. Compared to food cues, cocaine cues produced lower activation in insula and postcentral gyrus, and less deactivation in hypothalamus and DMN regions. Activation in cortical regions and cerebellum increased in proportion to the valence of the cues, and activation to food cues in somatosensory and orbitofrontal cortices also increased in proportion to body mass. Longer exposure to cocaine was associated with lower activation to both cues in occipital cortex and cerebellum, which could reflect the decreases in D2/D3 receptors associated with chronicity. In conclusion, these findings show that cocaine cues activate similar, though not identical, pathways to those activated by food cues and that striatal D2/D3 receptors modulate these responses, suggesting that chronic cocaine exposure might influence brain sensitivity not just to drugs but also to food cues.},
doi = {10.1002/hbm.22617},
journal = {Human Brain Mapping},
number = 1,
volume = 36,
place = {United States},
year = {Wed Aug 20 00:00:00 EDT 2014},
month = {Wed Aug 20 00:00:00 EDT 2014}
}
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Cannabis Addiction and the Brain: a Review
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