Search Menu
DOE PAGES title logo U.S. Department of Energy
Office of Scientific and Technical Information
Search Scholarly Publications

Title: Addition of CFCl3 to Aromatic Aldehydes via in Situ Grignard Reaction

Journal Article · · Molecules
 [1];  [2];  [1]
  1. Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)
  2. Independent Researcher, Guwahati (India)
+ Show Author Affiliations

In the case of synthetic modification of trichlorofluoromethane (CFCl3) to non-volatile and useful fluorinated precursors, we realized that it is a cost-effective and an environmentally benign strategy for the safe consumption/destruction of the ozone depleting potential of the reagent. In our report, we present a novel method for in situ Grignard reaction using magnesium powder and CFCl3 for synthesis of dichlorofluoromethyl aromatic alcohols.

Research Organization:
Oak Ridge National Laboratory (ORNL), Oak Ridge, TN (United States). Center for Nanophase Materials Sciences (CNMS)
Sponsoring Organization:
USDOE Office of Science (SC)
Grant/Contract Number:
AC05-00OR22725
OSTI ID:
1265863
Journal Information:
Molecules, Journal Name: Molecules Journal Issue: 8 Vol. 20; ISSN MOLEFW; ISSN 1420-3049
Publisher:
MDPICopyright Statement
Country of Publication:
United States
Language:
English

References (28)

A LiCl-Mediated Br/Mg Exchange Reaction for the Preparation of Functionalized Aryl- and Heteroarylmagnesium Compounds from Organic Bromides journal June 2004
Amorphous Aluminum Bromide Fluoride (ABF) journal December 2004
Addition of CFCl3 to Aromatic Aldehydes under Ultrasonic Irradiation. journal July 2006
New Synthetic Routes Towards Various α-Fluorinated Aryl Ketones and Their Enantioselective Reductions Using Baker′s Yeast. journal May 2007
Chemistry of Trichlorofluoromethane:  Synthesis of Chlorofluoromethyl Phenyl Sulfone and Fluoromethyl Phenyl Sulfone and Some of Their Reactions journal January 2001
Chlorofluorocarbene from reaction of fluorotrichloromethane with reduced titanium. Synthesis of 1-chloro-1-fluorocyclopropanes journal January 1990
Fluorochloro-, fluorobromo-, and monofluorocarbene generation via organolithium reagents journal March 1977
Interconversion of chlorofluorocarbons in plasmas journal January 1995
Addition of CFCl3to Aromatic Aldehydes under Ultrasonic Irradiation journal January 2006
Highly Enantiomerically Enrichedα-Haloalkyl Grignard Reagents journal September 2000
A LiCl-Mediated Br/Mg Exchange Reaction for the Preparation of Functionalized Aryl- and Heteroarylmagnesium Compounds from Organic Bromides journal June 2004
Amorphous Aluminum Bromide Fluoride (ABF) journal December 2004
Addition of CFCl3 to Aromatic Aldehydes under Ultrasonic Irradiation. journal July 2006
A Novel Approach to 2-Chloro-2-fluorostyrenes journal January 2003
Reductive addition of polychlorofluoroalkanes to fluorocarbonyl compounds journal June 1996
Reductive addition of trichlorofluoromethane to ketones initiated by the Mg/LiC1 system journal April 1994
Direct electroreduction or use of an electrogenerated base : two ways for the coupling of polyhalogenated compounds with aldehydes or ketones. journal February 1997
Reductive alkylation of perfluorocarboxylic acid esters with CCl3F or CCl4 and synthesis of higher linear perfluoroketones journal December 2004
New synthetic routes towards various α-fluorinated aryl ketones and their enantioselective reductions using baker's yeast journal January 2007
A remarkably simple preparation of (trifluoromethyl)cadmium and -zinc reagents directly from difluorodihalomethanes journal August 1985
Chemistry of Trichlorofluoromethane:  Synthesis of Chlorofluoromethyl Phenyl Sulfone and Fluoromethyl Phenyl Sulfone and Some of Their Reactions journal January 2001
Chlorofluorocarbene from reaction of fluorotrichloromethane with reduced titanium. Synthesis of 1-chloro-1-fluorocyclopropanes journal January 1990
Fluorochloro-, fluorobromo-, and monofluorocarbene generation via organolithium reagents journal March 1977
Interconversion of chlorofluorocarbons in plasmas journal January 1995
1, 1-Diaryl- and 1-Aryl-2-chloro-2-fluoroethylenes journal May 1967
Hydrophobic Vitamin B12. Part 20: Supernucleophilicity of Co(I) Heptamethyl Cobyrinate toward Various Organic Halides journal May 2005
A Facile Procedure for the Generation of Dichlorocarbene from the Reaction of Carbon Tetrachloride and Magnesium using Ultrasonic Irradiation journal July 2003
The Halogen/Magnesium-Exchange Using iPrMgCl·LiCl and Related Exchange Reagents journal January 2014

Similar Records

Related Subjects

37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY
CFCl3
aromatic aldehydes
grignard reaction
in-situ process
magnesium