Search Menu
DOE PAGES title logo U.S. Department of Energy
Office of Scientific and Technical Information
Search Scholarly Publications

Title: Seeing through walls at the nanoscale: Microwave microscopy of enclosed objects and processes in liquids

Abstract

Here, noninvasive in situ nanoscale imaging in liquid environments is a current imperative in the analysis of delicate biomedical objects and electrochemical processes at reactive liquid–solid interfaces. Microwaves of a few gigahertz frequencies offer photons with energies of ≈10 μeV, which can affect neither electronic states nor chemical bonds in condensed matter. Here, we describe an implementation of scanning near-field microwave microscopy for imaging in liquids using ultrathin molecular impermeable membranes separating scanning probes from samples enclosed in environmental cells. We imaged a model electroplating reaction as well as individual live cells. Through a side-by-side comparison of the microwave imaging with scanning electron microscopy, we demonstrate the advantage of microwaves for artifact-free imaging.

Authors:
 [1];  [2];  [3];  [2];  [2]
+ Show Author Affiliations
  1. National Institute of Standards and Technology, Gaithersburg, MD (United States); Univ. of Maryland, College Park, MD (United States)
  2. Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)
  3. National Institute of Standards and Technology, Gaithersburg, MD (United States)
Publication Date:
Research Org.:
Oak Ridge National Laboratory (ORNL), Oak Ridge, TN (United States)
Sponsoring Org.:
USDOE Office of Science (SC)
OSTI Identifier:
1247944
Grant/Contract Number:  
AC05-00OR22725
Resource Type:
Accepted Manuscript
Journal Name:
ACS Nano
Additional Journal Information:
Journal Volume: 10; Journal Issue: 3; Journal ID: ISSN 1936-0851
Publisher:
American Chemical Society
Country of Publication:
United States
Language:
English
Subject:
77 NANOSCIENCE AND NANOTECHNOLOGY; in situ imaging; radiolysis-free in-liquid imaging; encapsulation; near-field microwave microscopy

Citation Formats

Velmurugan, Jeyavel, Kalinin, Sergei V., Kolmakov, Andrei, Tselev, Alexander, and Ievlev, Anton V. Seeing through walls at the nanoscale: Microwave microscopy of enclosed objects and processes in liquids. United States: N. p., 2016. Web. doi:10.1021/acsnano.5b07919.
Copy to clipboard
Velmurugan, Jeyavel, Kalinin, Sergei V., Kolmakov, Andrei, Tselev, Alexander, & Ievlev, Anton V. Seeing through walls at the nanoscale: Microwave microscopy of enclosed objects and processes in liquids. United States. https://doi.org/10.1021/acsnano.5b07919
Copy to clipboard
Velmurugan, Jeyavel, Kalinin, Sergei V., Kolmakov, Andrei, Tselev, Alexander, and Ievlev, Anton V. Thu . "Seeing through walls at the nanoscale: Microwave microscopy of enclosed objects and processes in liquids". United States. https://doi.org/10.1021/acsnano.5b07919. https://www.osti.gov/servlets/purl/1247944.
Copy to clipboard
@article{osti_1247944,
title = {Seeing through walls at the nanoscale: Microwave microscopy of enclosed objects and processes in liquids},
author = {Velmurugan, Jeyavel and Kalinin, Sergei V. and Kolmakov, Andrei and Tselev, Alexander and Ievlev, Anton V.},
abstractNote = {Here, noninvasive in situ nanoscale imaging in liquid environments is a current imperative in the analysis of delicate biomedical objects and electrochemical processes at reactive liquid–solid interfaces. Microwaves of a few gigahertz frequencies offer photons with energies of ≈10 μeV, which can affect neither electronic states nor chemical bonds in condensed matter. Here, we describe an implementation of scanning near-field microwave microscopy for imaging in liquids using ultrathin molecular impermeable membranes separating scanning probes from samples enclosed in environmental cells. We imaged a model electroplating reaction as well as individual live cells. Through a side-by-side comparison of the microwave imaging with scanning electron microscopy, we demonstrate the advantage of microwaves for artifact-free imaging.},
doi = {10.1021/acsnano.5b07919},
journal = {ACS Nano},
number = 3,
volume = 10,
place = {United States},
year = {Thu Feb 11 00:00:00 EST 2016},
month = {Thu Feb 11 00:00:00 EST 2016}
}
Copy to clipboard
Journal Article:
Free Publicly Available Full Text
Publisher's Version of Record
https://doi.org/10.1021/acsnano.5b07919
Copyright Statement
Other availability
Search WorldCat Search WorldCat to find libraries that may hold this journal
Citation Metrics:
Cited by: 35 works
Citation information provided by
Web of Science
Save / Share:
Export Metadata
Save to My Library
You must Sign In or Create an Account in order to save documents to your library.

Works referenced in this record:

An apparatus for imaging liquids, cells, and other wet samples in the scanning electron microscopy
journal, July 2004

  • Thiberge, S.; Zik, O.; Moses, E.
  • Review of Scientific Instruments, Vol. 75, Issue 7
  • DOI: 10.1063/1.1763262

Electron microscopy of specimens in liquid
journal, October 2011

  • de Jonge, Niels; Ross, Frances M.
  • Nature Nanotechnology, Vol. 6, Issue 11, p. 695-704
  • DOI: 10.1038/nnano.2011.161

Electron transparent graphene windows for environmental scanning electron microscopy in liquids and dense gases
journal, November 2012

Observation of biological samples using a scanning microwave microscope
journal, January 2005

Near-Field Optics: Microscopy, Spectroscopy, and Surface Modification Beyond the Diffraction Limit
journal, July 1992

In Situ Spatial and Time-Resolved Studies of Electrochemical Reactions by Scanning Transmission X-ray Microscopy
journal, June 2005

  • Guay, Daniel; Stewart-Ornstein, Jacob; Zhang, Xuerong
  • Analytical Chemistry, Vol. 77, Issue 11
  • DOI: 10.1021/ac048077j

Lattice light-sheet microscopy: Imaging molecules to embryos at high spatiotemporal resolution
journal, October 2014

Three-dimensional microwave tomography: initial experimental imaging of animals
journal, January 2002

  • Semenov, S. Y.; Svenson, R. H.; Bulyshev, A. E.
  • IEEE Transactions on Biomedical Engineering, Vol. 49, Issue 1
  • DOI: 10.1109/10.972840

Detection of defects buried in metallic samples by scanning microwave microscopy
journal, March 2011

Diffusion‐Controlled Multisweep Cyclic Voltammetry: III . Deposition of Silver on Stationary and Rotating‐Disk Electrodes
journal, July 1984

  • Andricacos, P. C.; Ross, P. N.
  • Journal of The Electrochemical Society, Vol. 131, Issue 7
  • DOI: 10.1149/1.2115887

Spatial resolution, information limit, and contrast transfer in piezoresponse force microscopy
journal, June 2006

Reactions of electrons in glycerol
journal, June 1972

  • Kajiwara, Takashi; Thomas, J. K.
  • The Journal of Physical Chemistry, Vol. 76, Issue 12
  • DOI: 10.1021/j100656a005

Tomographic effects of near-field microwave microscopy in the investigation of muscle cells interacting with multi-walled carbon nanotubes
journal, November 2012

  • Farina, Marco; Di Donato, Andrea; Monti, Tamara
  • Applied Physics Letters, Vol. 101, Issue 20
  • DOI: 10.1063/1.4767518

High-speed AFM and nano-visualization of biomolecular processes
journal, December 2007

  • Ando, Toshio; Uchihashi, Takayuki; Kodera, Noriyuki
  • Pflügers Archiv - European Journal of Physiology, Vol. 456, Issue 1
  • DOI: 10.1007/s00424-007-0406-0

Nanoscale Measurement of the Dielectric Constant of Supported Lipid Bilayers in Aqueous Solutions with Electrostatic Force Microscopy
journal, March 2013

Batch-fabricated cantilever probes with electrical shielding for nanoscale dielectric and conductivity imaging
journal, October 2012

Electrochemical formation and reduction of silver oxides in alkaline media
journal, December 1980

  • Droog, John M. M.; Huisman, Fred
  • Journal of Electroanalytical Chemistry and Interfacial Electrochemistry, Vol. 115, Issue 2
  • DOI: 10.1016/S0022-0728(80)80326-3

Subsurface Near-Field Scanning Tomography
journal, May 2007

Microwave imaging via space-time beamforming for early detection of breast cancer
journal, August 2003

  • Bond, E. J.; Hagness, S. C.
  • IEEE Transactions on Antennas and Propagation, Vol. 51, Issue 8
  • DOI: 10.1109/TAP.2003.815446

A flat Universe from high-resolution maps of the cosmic microwave background radiation
journal, April 2000

  • de Bernardis, P.; Ade, P. A. R.; Bock, J. J.
  • Nature, Vol. 404, Issue 6781
  • DOI: 10.1038/35010035

Anodic silver (II) oxides investigated by combined electrochemistry, ex situ XPS and in situ X-ray absorption spectroscopy: EXAFS and XPS of anodic Ag(II)-oxides
journal, September 2009

  • Lützenkirchen-Hecht, Dirk; Strehblow, Hans-Henning
  • Surface and Interface Analysis, Vol. 41, Issue 10
  • DOI: 10.1002/sia.3106

Graphene oxide windows for in situ environmental cell photoelectron spectroscopy
journal, August 2011

  • Kolmakov, Andrei; Dikin, Dmitriy A.; Cote, Laura J.
  • Nature Nanotechnology, Vol. 6, Issue 10
  • DOI: 10.1038/nnano.2011.130

High-Resolution EM of Colloidal Nanocrystal Growth Using Graphene Liquid Cells
journal, April 2012

Atomic-force-microscope-compatible near-field scanning microwave microscope with separated excitation and sensing probes
journal, June 2007

  • Lai, K.; Ji, M. B.; Leindecker, N.
  • Review of Scientific Instruments, Vol. 78, Issue 6
  • DOI: 10.1063/1.2746768

Electron–Water Interactions and Implications for Liquid Cell Electron Microscopy
journal, September 2014

  • Schneider, Nicholas M.; Norton, Michael M.; Mendel, Brian J.
  • The Journal of Physical Chemistry C, Vol. 118, Issue 38
  • DOI: 10.1021/jp507400n

Distance control for a near-field scanning microwave microscope in liquid using a quartz tuning fork
journal, April 2005

  • Kim, Songhui; Yoo, Hyunjun; Lee, Kiejin
  • Applied Physics Letters, Vol. 86, Issue 15
  • DOI: 10.1063/1.1904713

Soft X-ray microscopy and spectroscopy at the molecular environmental science beamline at the Advanced Light Source
journal, February 2006

  • Bluhm, H.; Andersson, K.; Araki, T.
  • Journal of Electron Spectroscopy and Related Phenomena, Vol. 150, Issue 2-3
  • DOI: 10.1016/j.elspec.2005.07.005

(Invited) Scanning Probe Microscopes for Subsurface Imaging
journal, March 2014

Scanning Electrochemical Microscopy
journal, July 2008

Confocal microwave imaging for breast cancer detection: localization of tumors in three dimensions
journal, August 2002

  • Fear, E. C.; Li, X.; Hagness, S. C.
  • IEEE Transactions on Biomedical Engineering, Vol. 49, Issue 8
  • DOI: 10.1109/TBME.2002.800759

High Resolution Scanning Microwave Microscopy for Applications in Liquid Environment
journal, November 2012

  • Farina, M.; Di Donato, A.; Mencarelli, D.
  • IEEE Microwave and Wireless Components Letters, Vol. 22, Issue 11
  • DOI: 10.1109/LMWC.2012.2225607

Scanning electron microscopy of cells and tissues under fully hydrated conditions
journal, February 2004

  • Thiberge, S.; Nechushtan, A.; Sprinzak, D.
  • Proceedings of the National Academy of Sciences, Vol. 101, Issue 10
  • DOI: 10.1073/pnas.0400088101

High-frequency electromagnetic dynamics properties of THP1 cells using scanning microwave microscopy
journal, November 2011

Electrochemical nucleation from molten salts—I. Diffusion controlled electrodeposition of silver from alkali molten nitrates
journal, November 1974

Nanoscale Electric Permittivity of Single Bacterial Cells at Gigahertz Frequencies by Scanning Microwave Microscopy
journal, December 2015

Three decades of active microwave imaging achievements, difficulties and future challenges
conference, August 2010

  • Bolomey, Jean-Charles; Jofre, Lluis
  • 2010 IEEE International Conference on Wireless Information Technology and Systems (ICWITS)
  • DOI: 10.1109/ICWITS.2010.5611904
    Sort by:
    [ × clear filter / sort ]

    Works referencing / citing this record:

    Scanning microwave microscopy applied to semiconducting GaAs structures
    journal, February 2018

    • Buchter, Arne; Hoffmann, Johannes; Delvallée, Alexandra
    • Review of Scientific Instruments, Vol. 89, Issue 2
    • DOI: 10.1063/1.5015966

    Quantitative measurements of nanoscale permittivity and conductivity using tuning-fork-based microwave impedance microscopy
    journal, April 2018

    • Wu, Xiaoyu; Hao, Zhenqi; Wu, Di
    • Review of Scientific Instruments, Vol. 89, Issue 4
    • DOI: 10.1063/1.5022997

    Anomalously low dielectric constant of confined water
    journal, June 2018

    In-situ near-field probe microscopy of plasma processing
    journal, December 2018

    • Tselev, Alexander; Fagan, Jeffrey; Kolmakov, Andrei
    • Applied Physics Letters, Vol. 113, Issue 26
    • DOI: 10.1063/1.5049592

    Electron energy loss spectroscopy of wall charges in plasma-facing dielectrics
    text, January 2019

    Electron energy loss spectroscopy of wall charges in plasma-facing dielectrics
    journal, September 2019

    • Thiessen, E.; Bronold, F. X.; Fehske, H.
    • Plasma Sources Science and Technology, Vol. 28, Issue 9
    • DOI: 10.1088/1361-6595/ab2d6b

    Anomalously low dielectric constant of confined water
    text, January 2018

    Microwave Sensors for Breast Cancer Detection
    journal, February 2018

    Spatial Resolution and Capacitive Coupling in the Characterization of Nanowire Nanocomposites by Scanning Dielectric Microscopy
    journal, July 2021

    • Balakrishnan, Harishankar; Fabregas, Rene; Millan-Solsona, Ruben
    • Microscopy and Microanalysis, Vol. 27, Issue 5
    • DOI: 10.1017/s1431927621012319

    Full-wave modeling of broadband near field scanning microwave microscopy
    journal, November 2017

    Multimodal imaging technology by integrated scanning electron, force, and microwave microscopy and its application to study microscaled capacitors
    journal, March 2018

    • Haenssler, Olaf C.; Fatikow, Sergej; Theron, Didier
    • Journal of Vacuum Science & Technology B, Nanotechnology and Microelectronics: Materials, Processing, Measurement, and Phenomena, Vol. 36, Issue 2
    • DOI: 10.1116/1.5006161

    Microwave Sensors for Breast Cancer Detection
    journal, February 2018

      Sort by:
      [ × clear filter / sort ]

      Similar Records in DOE PAGES and OSTI.GOV collections: