Biosensor-based engineering of biosynthetic pathways
Abstract
Biosynthetic pathways provide an enzymatic route from inexpensive renewable resources to valuable metabolic products such as pharmaceuticals and plastics. However, designing these pathways is challenging due to the complexities of biology. Advances in the design and construction of genetic variants has enabled billions of cells, each possessing a slightly different metabolic design, to be rapidly generated. However, our ability to measure the quality of these designs lags by several orders of magnitude. Recent research has enabled cells to report their own success in chemical production through the use of genetically encoded biosensors. A new engineering discipline is emerging around the creation and application of biosensors. Biosensors, implemented in selections and screens to identify productive cells, are paving the way for a new era of biotechnological progress.
- Authors:
-
- Harvard Univ., Boston, MA (United States). Wyss Inst. For Biologically Inspired Engineering
- Publication Date:
- Research Org.:
- Harvard Univ., Cambridge, MA (United States)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1242558
- Alternate Identifier(s):
- OSTI ID: 1429374
- Grant/Contract Number:
- FG02-02ER63445
- Resource Type:
- Published Article
- Journal Name:
- Current Opinion in Biotechnology
- Additional Journal Information:
- Journal Name: Current Opinion in Biotechnology Journal Volume: 42 Journal Issue: C; Journal ID: ISSN 0958-1669
- Publisher:
- Elsevier
- Country of Publication:
- United Kingdom
- Language:
- English
- Subject:
- 59 BASIC BIOLOGICAL SCIENCES; 36 MATERIALS SCIENCE
Citation Formats
Rogers, Jameson K., Taylor, Noah D., and Church, George M. Biosensor-based engineering of biosynthetic pathways. United Kingdom: N. p., 2016.
Web. doi:10.1016/j.copbio.2016.03.005.
Rogers, Jameson K., Taylor, Noah D., & Church, George M. Biosensor-based engineering of biosynthetic pathways. United Kingdom. https://doi.org/10.1016/j.copbio.2016.03.005
Rogers, Jameson K., Taylor, Noah D., and Church, George M. Fri .
"Biosensor-based engineering of biosynthetic pathways". United Kingdom. https://doi.org/10.1016/j.copbio.2016.03.005.
@article{osti_1242558,
title = {Biosensor-based engineering of biosynthetic pathways},
author = {Rogers, Jameson K. and Taylor, Noah D. and Church, George M.},
abstractNote = {Biosynthetic pathways provide an enzymatic route from inexpensive renewable resources to valuable metabolic products such as pharmaceuticals and plastics. However, designing these pathways is challenging due to the complexities of biology. Advances in the design and construction of genetic variants has enabled billions of cells, each possessing a slightly different metabolic design, to be rapidly generated. However, our ability to measure the quality of these designs lags by several orders of magnitude. Recent research has enabled cells to report their own success in chemical production through the use of genetically encoded biosensors. A new engineering discipline is emerging around the creation and application of biosensors. Biosensors, implemented in selections and screens to identify productive cells, are paving the way for a new era of biotechnological progress.},
doi = {10.1016/j.copbio.2016.03.005},
journal = {Current Opinion in Biotechnology},
number = C,
volume = 42,
place = {United Kingdom},
year = {Fri Mar 18 00:00:00 EDT 2016},
month = {Fri Mar 18 00:00:00 EDT 2016}
}
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https://doi.org/10.1016/j.copbio.2016.03.005
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