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Title: Biosensor-based engineering of biosynthetic pathways

Abstract

Biosynthetic pathways provide an enzymatic route from inexpensive renewable resources to valuable metabolic products such as pharmaceuticals and plastics. However, designing these pathways is challenging due to the complexities of biology. Advances in the design and construction of genetic variants has enabled billions of cells, each possessing a slightly different metabolic design, to be rapidly generated. However, our ability to measure the quality of these designs lags by several orders of magnitude. Recent research has enabled cells to report their own success in chemical production through the use of genetically encoded biosensors. A new engineering discipline is emerging around the creation and application of biosensors. Biosensors, implemented in selections and screens to identify productive cells, are paving the way for a new era of biotechnological progress.

Authors:
 [1];  [1];  [1]
  1. Harvard Univ., Boston, MA (United States). Wyss Inst. For Biologically Inspired Engineering
Publication Date:
Research Org.:
Harvard Univ., Boston, MA (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1242558
Alternate Identifier(s):
OSTI ID: 1429374
Grant/Contract Number:  
FG02-02ER63445
Resource Type:
Published Article
Journal Name:
Current Opinion in Biotechnology
Additional Journal Information:
Journal Volume: 42; Journal Issue: C; Journal ID: ISSN 0958-1669
Publisher:
Elsevier
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; 36 MATERIALS SCIENCE

Citation Formats

Rogers, Jameson K., Taylor, Noah D., and Church, George M.. Biosensor-based engineering of biosynthetic pathways. United States: N. p., 2016. Web. doi:10.1016/j.copbio.2016.03.005.
Rogers, Jameson K., Taylor, Noah D., & Church, George M.. Biosensor-based engineering of biosynthetic pathways. United States. doi:10.1016/j.copbio.2016.03.005.
Rogers, Jameson K., Taylor, Noah D., and Church, George M.. Fri . "Biosensor-based engineering of biosynthetic pathways". United States. doi:10.1016/j.copbio.2016.03.005.
@article{osti_1242558,
title = {Biosensor-based engineering of biosynthetic pathways},
author = {Rogers, Jameson K. and Taylor, Noah D. and Church, George M.},
abstractNote = {Biosynthetic pathways provide an enzymatic route from inexpensive renewable resources to valuable metabolic products such as pharmaceuticals and plastics. However, designing these pathways is challenging due to the complexities of biology. Advances in the design and construction of genetic variants has enabled billions of cells, each possessing a slightly different metabolic design, to be rapidly generated. However, our ability to measure the quality of these designs lags by several orders of magnitude. Recent research has enabled cells to report their own success in chemical production through the use of genetically encoded biosensors. A new engineering discipline is emerging around the creation and application of biosensors. Biosensors, implemented in selections and screens to identify productive cells, are paving the way for a new era of biotechnological progress.},
doi = {10.1016/j.copbio.2016.03.005},
journal = {Current Opinion in Biotechnology},
number = C,
volume = 42,
place = {United States},
year = {2016},
month = {3}
}

Journal Article:
Free Publicly Available Full Text
Publisher's Version of Record
DOI: 10.1016/j.copbio.2016.03.005

Citation Metrics:
Cited by: 26 works
Citation information provided by
Web of Science

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