Dried plum diet protects from bone loss caused by ionizing radiation

Schreurs, A. -S.; Shirazi-Fard, Y.; Shahnazari, M.; Alwood, J. S.; Truong, T. A.; Tahimic, C. G. T.; Limoli, C. L.; Turner, N. D.; Halloran, B.; Globus, R. K.

doi:10.1038/srep21343

Title: Dried plum diet protects from bone loss caused by ionizing radiation

Journal Article · Thu Feb 11 04:00:00 UTC 2016 · Scientific Reports

DOI: https://doi.org/10.1038/srep21343 · OSTI ID:1242248

Schreurs, A. -S. ^[1]; Shirazi-Fard, Y. ^[2]; Shahnazari, M. ^[2]; Alwood, J. S. ^[2]; Truong, T. A. ^[2]; Tahimic, C. G. T. ^[2]; Limoli, C. L. ^[3]; Turner, N. D. ^[4]; Halloran, B. ^[5]; Globus, R. K. ^[2]

NASA Ames Research Center, Moffett Field, CA (United States); NASA Ames Research Center
NASA Ames Research Center, Moffett Field, CA (United States)
Univ. of California, Irvine, CA (United States)
Texas A & M Univ., College Station, TX (United States)
Univ. of California, San Francisco, CA (United States)

Bone loss caused by ionizing radiation is a potential health concern for radiotherapy patients, radiation workers and astronauts. In animal studies, exposure to ionizing radiation increases oxidative damage in skeletal tissues, and results in an imbalance in bone remodeling initiated by increased bone-resorbing osteoclasts. Therefore, we evaluated various candidate interventions with antioxidant or antiinflammatory activities (antioxidant cocktail, dihydrolipoic acid, ibuprofen, dried plum) both for their ability to blunt the expression of resorption-related genes in marrow cells after irradiation with either gamma rays (photons, 2 Gy) or simulated space radiation (protons and heavy ions, 1 Gy) and to prevent bone loss. Dried plum was most effective in reducing the expression of genes related to bone resorption (Nfe2l2, Rankl, Mcp1, Opg, TNF-α) and also preventing later cancellous bone decrements caused by irradiation with either photons or heavy ions. Furthermore, dietary supplementation with DP may prevent the skeletal effects of radiation exposures either in space or on Earth.

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Research Organization:: NASA Ames Research Center, Moffett Field, CA (United States)

Sponsoring Organization:: USDOE Office of Science (SC), Biological and Environmental Research (BER) (SC-23)

Grant/Contract Number:: SC0001507

OSTI ID:: 1242248

Journal Information:: Scientific Reports, Journal Name: Scientific Reports Vol. 6; ISSN 2045-2322

Publisher:: Nature Publishing GroupCopyright Statement

Country of Publication:: United States

Language:: English

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Low-Dose, Ionizing Radiation and Age-Related Changes in Skeletal Microarchitecture Alwood, Joshua S.; Kumar, Akhilesh; Tran, Luan H. Journal of Aging Research, Vol. 2012 https://doi.org/10.1155/2012/481983	journal	January 2012
Rabbiteye blueberry prevents osteoporosis in ovariectomized rats Li, Tao; Wu, Shou-Mian; Xu, Zhi-Yuan Journal of Orthopaedic Surgery and Research, Vol. 9, Issue 1 https://doi.org/10.1186/s13018-014-0056-9	journal	August 2014
Dried Plum’s Unique Capacity to Reverse Bone Loss and Alter Bone Metabolism in Postmenopausal Osteoporosis Model Rendina, Elizabeth; Hembree, Kelsey D.; Davis, McKale R. PLoS ONE, Vol. 8, Issue 3 https://doi.org/10.1371/journal.pone.0060569	journal	March 2013
Microgravity Induces Pelvic Bone Loss through Osteoclastic Activity, Osteocytic Osteolysis, and Osteoblastic Cell Cycle Inhibition by CDKN1a/p21 Blaber, Elizabeth A.; Dvorochkin, Natalya; Lee, Chialing PLoS ONE, Vol. 8, Issue 4 https://doi.org/10.1371/journal.pone.0061372	journal	April 2013
Feeding Blueberry Diets to Young Rats Dose-Dependently Inhibits Bone Resorption through Suppression of RANKL in Stromal Cells Zhang, Jian; Lazarenko, Oxana P.; Kang, Jie PLoS ONE, Vol. 8, Issue 8 https://doi.org/10.1371/journal.pone.0070438	journal	August 2013
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Bone mineral loss induced by anticancer treatment for gynecological malignancies in premenopausal women Nishio, Keina; Tanabe, Akiko; Maruoka, Risa Endocrine Connections, Vol. 2, Issue 1 https://doi.org/10.1530/ec-12-0043	journal	March 2013
Dietary Antioxidants Protect Hematopoietic Cells and Improve Animal Survival after Total-Body Irradiation Wambi, Chris; Sanzari, Jenine; Wan, X. Steven Radiation Research, Vol. 169, Issue 4 https://doi.org/10.1667/RR1204.1	journal	April 2008
Effects of Dietary Antioxidant Supplementation on the Development of Malignant Lymphoma and Other Neoplastic Lesions in Mice Exposed to Proton or Iron-Ion Radiation Kennedy, Ann R.; Davis, James G.; Carlton, William Radiation Research, Vol. 169, Issue 6 https://doi.org/10.1667/RR1296.1	journal	June 2008
Early Increase in Osteoclast Number in Mice after Whole-Body Irradiation with 2 Gy X Rays Willey, Jeffrey S.; Lloyd, Shane A. J.; Robbins, Michael E. Radiation Research, Vol. 170, Issue 3 https://doi.org/10.1667/RR1388.1	journal	September 2008
Total-Body Irradiation of Postpubertal Mice with ¹³⁷ Cs Acutely Compromises the Microarchitecture of Cancellous Bone and Increases Osteoclasts Kondo, Hisataka; Searby, Nancy D.; Mojarrab, Rose Radiation Research, Vol. 171, Issue 3 https://doi.org/10.1667/RR1463.1	journal	March 2009
Antioxidant Diet Supplementation Starting 24 Hours after Exposure Reduces Radiation Lethality Brown, Stephen L.; Kolozsvary, Andrew; Liu, Jianguo Radiation Research, Vol. 173, Issue 4 https://doi.org/10.1667/RR1716.1	journal	April 2010
Short-Term Effects of Whole-Body Exposure to ⁵⁶ Fe Ions in Combination with Musculoskeletal Disuse on Bone Cells Yumoto, Kenji; Globus, Ruth K.; Mojarrab, Rose Radiation Research, Vol. 173, Issue 4 https://doi.org/10.1667/RR1754.1	journal	April 2010
Antioxidant-Chemoprevention Diet Ameliorates Late Effects of Total-Body Irradiation and Supplements Radioprotection by MnSOD-Plasmid Liposome Administration Epperly, Michael W.; Wang, Hong; Jones, Jeffrey A. Radiation Research, Vol. 175, Issue 6 https://doi.org/10.1667/RR2398.1	journal	June 2011
Effects of Dietary Supplements on the Space Radiation-Induced Reduction in Total Antioxidant Status in CBA Mice Guan, Jun; Stewart, Jelena; Ware, Jeffrey H. Radiation Research, Vol. 165, Issue 4 https://doi.org/10.1667/RR3523.1	journal	April 2006
Exposure to Ionizing Radiation and Development of Bone Sarcoma: New Insights Based on Atomic-Bomb Survivors of Hiroshima and Nagasaki Samartzis, Dino; Nishi, Nobuo; Hayashi, Mikiko The Journal of Bone and Joint Surgery-American Volume, Vol. 93, Issue 11 https://doi.org/10.2106/JBJS.J.00256	journal	January 2011
Sclerostin inhibition: a novel therapeutic approach in the treatment of osteoporosis Lewiecki, E. Michael; Shah, Arti; Shoback, Dolores International Journal of Women's Health https://doi.org/10.2147/IJWH.S73244	journal	June 2015
Anti-hyperglycemic effects of plum in a rat model of obesity and type 2 diabetes, Wistar fatty rat Utsunomiya, Hirotoshi; Yamakawa, Tadashi; Kamei, Junzo Biomedical Research, Vol. 26, Issue 5 https://doi.org/10.2220/biomedres.26.193	journal	January 2005
The combined effects of reduced weightbearing and ionizing radiation on splenic lymphocyte population and function Sanzari, Jenine K.; Wilson, Jolaine M.; Wagner, Erika B. International Journal of Radiation Biology, Vol. 87, Issue 10 https://doi.org/10.3109/09553002.2011.595875	journal	July 2011
Space Radiation: The Number One Risk to Astronaut Health beyond Low Earth Orbit Chancellor, Jeffery; Scott, Graham; Sutton, Jeffrey Life, Vol. 4, Issue 3 https://doi.org/10.3390/life4030491	journal	September 2014
Dietary Dried Plum Increases Bone Mass in Adult and Aged Male Mice Halloran, Bernard P.; Wronski, Thomas J.; VonHerzen, Douglas C. The Journal of Nutrition, Vol. 140, Issue 10 https://doi.org/10.3945/jn.110.124198	journal	August 2010

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Redox Signaling and Its Impact on Skeletal and Vascular Responses to Spaceflight Tahimic, Candice; Globus, Ruth International Journal of Molecular Sciences, Vol. 18, Issue 10 https://doi.org/10.3390/ijms18102153	journal	October 2017
Effects of Iron Overload and Oxidative Damage on the Musculoskeletal System in the Space Environment: Data from Spaceflights and Ground-Based Simulation Models Yang, Jiancheng; Zhang, Gejing; Dong, Dandan International Journal of Molecular Sciences, Vol. 19, Issue 9 https://doi.org/10.3390/ijms19092608	journal	September 2018
Dried Plums, Prunes and Bone Health: A Comprehensive Review Wallace, Taylor Nutrients, Vol. 9, Issue 4 https://doi.org/10.3390/nu9040401	journal	April 2017
Ionizing Radiation Exacerbates the Bone Loss Induced by Iron Overload in Mice Zhang, Jian; Qiao, Penghai; Yao, Gang Biological Trace Element Research, Vol. 196, Issue 2 https://doi.org/10.1007/s12011-019-01929-7	journal	November 2019
Radiation-Induced Bone Toxicity Okoukoni, Catherine; Farris, Michael; Hughes, Ryan T. Current Stem Cell Reports, Vol. 3, Issue 4 https://doi.org/10.1007/s40778-017-0099-z	journal	October 2017
Therapeutic ionizing radiation induced bone loss: a review of in vivo and in vitro findings Zhang, Jian; Qiu, Xinyu; Xi, Kedi Connective Tissue Research, Vol. 59, Issue 6 https://doi.org/10.1080/03008207.2018.1439482	journal	March 2018
Establishing mechanisms affecting the individual response to ionizing radiation Averbeck, Dietrich; Candéias, Serge; Chandna, Sudhir International Journal of Radiation Biology, Vol. 96, Issue 3 https://doi.org/10.1080/09553002.2019.1704908	journal	January 2020
A Moderate Daily Dose of Resveratrol Mitigates Muscle Deconditioning in a Martian Gravity Analog Mortreux, Marie; Riveros, Daniela; Bouxsein, Mary L. Frontiers in Physiology, Vol. 10 https://doi.org/10.3389/fphys.2019.00899	journal	July 2019
Effects of Iron Overload and Oxidative Damage on the Musculoskeletal System in the Space Environment: Data from Spaceflights and Ground-Based Simulation Models Yang, Jiancheng; Zhang, Gejing; Dong, Dandan International Journal of Molecular Sciences, Vol. 19, Issue 9 https://doi.org/10.3390/ijms19092608	journal	September 2018
Dried Plums, Prunes and Bone Health: A Comprehensive Review Wallace, Taylor Nutrients, Vol. 9, Issue 4 https://doi.org/10.3390/nu9040401	journal	April 2017

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