Supramolecular polymerization of a prebiotic nucleoside provides insights into the creation of sequence-controlled polymers
Abstract
The self-assembly of a nucleoside on Au(111) was studied to ascertain whether polymerization on well-defined substrates constitutes a promising approach for making sequence-controlled polymers. Scanning tunneling microscopy and density functional theory were used to investigate the self-assembly on Au(111) of (RS)-N9-(2,3-dihydroxypropyl)adenine (DHPA), a plausibly prebiotic nucleoside analog of adenosine. It is found that DHPA molecules self-assemble into a hydrogen-bonded polymer that grows almost exclusively along the herringbone reconstruction pattern, has a two component sequence that is repeated over hundreds of nanometers, and is erasable with electron-induced excitation. Although the sequence is simple, more complicated ones are envisioned if two or more nucleoside types are combined. Because polymerization occurs on a substrate in a dry environment, the success of each combination can be gauged with high-resolution imaging and accurate modeling techniques. The resulting characteristics make nucleoside self-assembly on a substrate an attractive approach for designing sequence-controlled polymers. Moreover, by choosing plausibly prebiotic nucleosides, insights may be provided into how nature created the first sequence-controlled polymers capable of storing information. Such insights, in turn, can inspire new ways of synthesizing sequence-controlled polymers.
- Authors:
-
- Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)
- Universidad Autonoma del Estado de Hidalgo, Mexico; Autonomous Univ. of the State of Hidalgo (Mexico)
- Tokyo Inst. of Technology (Japan); Inst. for Advanced Study, Princeton, NJ (United States); Blue Marble Space Inst. of Science, Washington, DC (United States); Georgia Inst. of Technology, Atlanta, GA (United States)
- Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Huazhong Univ. of Science and Technology, Wuhan (China)
- Publication Date:
- Research Org.:
- Oak Ridge National Laboratory (ORNL), Oak Ridge, TN (United States). Oak Ridge Leadership Computing Facility (OLCF); Oak Ridge National Laboratory (ORNL), Oak Ridge, TN (United States). Center for Nanophase Materials Sciences (CNMS)
- Sponsoring Org.:
- USDOE Office of Science (SC)
- OSTI Identifier:
- 1238003
- Grant/Contract Number:
- AC05-00OR22725
- Resource Type:
- Accepted Manuscript
- Journal Name:
- Scientific Reports
- Additional Journal Information:
- Journal Volume: 6; Journal ID: ISSN 2045-2322
- Publisher:
- Nature Publishing Group
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY
Citation Formats
Wang, Jun, Bonnesen, Peter V, Rangel, E., Vallejo, E., Sanchez-Castillo, Ariadna, Cleaves, II, H. James, Baddorf, Arthur P, Sumpter, Bobby G, Pan, Minghu, Maksymovych, Petro, and Fuentes-Cabrera, Miguel A. Supramolecular polymerization of a prebiotic nucleoside provides insights into the creation of sequence-controlled polymers. United States: N. p., 2016.
Web. doi:10.1038/srep18891.
Wang, Jun, Bonnesen, Peter V, Rangel, E., Vallejo, E., Sanchez-Castillo, Ariadna, Cleaves, II, H. James, Baddorf, Arthur P, Sumpter, Bobby G, Pan, Minghu, Maksymovych, Petro, & Fuentes-Cabrera, Miguel A. Supramolecular polymerization of a prebiotic nucleoside provides insights into the creation of sequence-controlled polymers. United States. https://doi.org/10.1038/srep18891
Wang, Jun, Bonnesen, Peter V, Rangel, E., Vallejo, E., Sanchez-Castillo, Ariadna, Cleaves, II, H. James, Baddorf, Arthur P, Sumpter, Bobby G, Pan, Minghu, Maksymovych, Petro, and Fuentes-Cabrera, Miguel A. Mon .
"Supramolecular polymerization of a prebiotic nucleoside provides insights into the creation of sequence-controlled polymers". United States. https://doi.org/10.1038/srep18891. https://www.osti.gov/servlets/purl/1238003.
@article{osti_1238003,
title = {Supramolecular polymerization of a prebiotic nucleoside provides insights into the creation of sequence-controlled polymers},
author = {Wang, Jun and Bonnesen, Peter V and Rangel, E. and Vallejo, E. and Sanchez-Castillo, Ariadna and Cleaves, II, H. James and Baddorf, Arthur P and Sumpter, Bobby G and Pan, Minghu and Maksymovych, Petro and Fuentes-Cabrera, Miguel A},
abstractNote = {The self-assembly of a nucleoside on Au(111) was studied to ascertain whether polymerization on well-defined substrates constitutes a promising approach for making sequence-controlled polymers. Scanning tunneling microscopy and density functional theory were used to investigate the self-assembly on Au(111) of (RS)-N9-(2,3-dihydroxypropyl)adenine (DHPA), a plausibly prebiotic nucleoside analog of adenosine. It is found that DHPA molecules self-assemble into a hydrogen-bonded polymer that grows almost exclusively along the herringbone reconstruction pattern, has a two component sequence that is repeated over hundreds of nanometers, and is erasable with electron-induced excitation. Although the sequence is simple, more complicated ones are envisioned if two or more nucleoside types are combined. Because polymerization occurs on a substrate in a dry environment, the success of each combination can be gauged with high-resolution imaging and accurate modeling techniques. The resulting characteristics make nucleoside self-assembly on a substrate an attractive approach for designing sequence-controlled polymers. Moreover, by choosing plausibly prebiotic nucleosides, insights may be provided into how nature created the first sequence-controlled polymers capable of storing information. Such insights, in turn, can inspire new ways of synthesizing sequence-controlled polymers.},
doi = {10.1038/srep18891},
journal = {Scientific Reports},
number = ,
volume = 6,
place = {United States},
year = {Mon Jan 04 00:00:00 EST 2016},
month = {Mon Jan 04 00:00:00 EST 2016}
}
Web of Science
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