Magnetic relaxometry as applied to sensitive cancer detection and localization

Journal Article · Tue Jun 02 00:00:00 EDT 2015 · Biomedizinische Technik

DOI: https://doi.org/10.1515/bmt-2015-0053 · OSTI ID:1227725

De Haro, Leyma P. ^[1]; Karaulanov, Todor ^[1]; Vreeland, Erika C. ^[1]; Anderson, Bill ^[1]; Hathaway, Helen J. ^[2]; Huber, Dale L. ^[3]; Matlashov, Andrei N. ^[4]; Nettles, Christopher P. ^[1]; Price, Andrew D. ^[1]; Monson, Todd C. ^[3]; Flynn, Edward R. ^[1]

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1. Senior Scientific LLC, Albuquerque, NM (United States)
2. Univ. of New Mexico School of Medicine, Albuquerque, NM (United States)
3. Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)
4. Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

Abstract Here we describe superparamagnetic relaxometry (SPMR), a technology that utilizes highly sensitive magnetic sensors and superparamagnetic nanoparticles for cancer detection. Using SPMR, we sensitively and specifically detect nanoparticles conjugated to biomarkers for various types of cancer. SPMR offers high contrast In SPMR measurements, a brief magnetizing pulse is used to align superparamagnetic nanoparticles of a discrete size. Following the pulse, an array of superconducting quantum interference detectors (SQUID) sensors detect the decaying magnetization field. NP size is chosen so that, when bound, the induced field decays in seconds. They are functionalized with specific biomarkers and incubated with cancer cells As a result, superparamagnetic NPs developed here have small size dispersion. Cell incubation studies measure specificity for different cell lines and antibodies with very high contrast.

• Research Organization: Los Alamos National Laboratory (LANL), Los Alamos, NM (United States)
• Sponsoring Organization: USDOE
• Grant/Contract Number: AC52-06NA25396
• OSTI ID: 1227725
• Report Number(s): LA-UR--15-21938
• Journal Information: Biomedizinische Technik, Journal Name: Biomedizinische Technik Journal Issue: 5 Vol. 60; ISSN 0013-5585
• Publisher: De GruyterCopyright Statement
• Country of Publication: United States
• Language: English