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Title: Discovery and Structure-Guided Optimization of Diarylmethanesulfonamide Disrupters of Glucokinase–Glucokinase Regulatory Protein (GK–GKRP) Binding: Strategic Use of a N → S (n N → σ* S–X ) Interaction for Conformational Constraint

Authors:
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+ Show Author Affiliations
  1. Medicinal Chemistry, ‡Molecular Structure and Characterization, §Pharmacokinetics and Drug Metabolism, ∥Metabolic Disorders Research, and ⊥Pathology, Amgen, One Amgen Center Drive, Thousand Oaks, California 91320-1799, United States
Publication Date:
Sponsoring Org.:
USDOE
OSTI Identifier:
1227324
Grant/Contract Number:  
AC02-05CH11231
Resource Type:
Published Article
Journal Name:
Journal of Medicinal Chemistry
Additional Journal Information:
Journal Name: Journal of Medicinal Chemistry Journal Volume: 58 Journal Issue: 24; Journal ID: ISSN 0022-2623
Publisher:
American Chemical Society
Country of Publication:
United States
Language:
English

Citation Formats

Pennington, Lewis D., Bartberger, Michael D., Croghan, Michael D., Andrews, Kristin L., Ashton, Kate S., Bourbeau, Matthew P., Chen, Jie, Chmait, Samer, Cupples, Rod, Fotsch, Christopher, Helmering, Joan, Hong, Fang-Tsao, Hungate, Randall W., Jordan, Steven R., Kong, Ke, Liu, Longbin, Michelsen, Klaus, Moyer, Carolyn, Nishimura, Nobuko, Norman, Mark H., Reichelt, Andreas, Siegmund, Aaron C., Sivits, Glenn, Tadesse, Seifu, Tegley, Christopher M., Van, Gwyneth, Yang, Kevin C., Yao, Guomin, Zhang, Jiandong, Lloyd, David J., Hale, Clarence, and St. Jean, Jr., David J. Discovery and Structure-Guided Optimization of Diarylmethanesulfonamide Disrupters of Glucokinase–Glucokinase Regulatory Protein (GK–GKRP) Binding: Strategic Use of a N → S (n N → σ* S–X ) Interaction for Conformational Constraint. United States: N. p., 2015. Web. doi:10.1021/acs.jmedchem.5b01367.
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Pennington, Lewis D., Bartberger, Michael D., Croghan, Michael D., Andrews, Kristin L., Ashton, Kate S., Bourbeau, Matthew P., Chen, Jie, Chmait, Samer, Cupples, Rod, Fotsch, Christopher, Helmering, Joan, Hong, Fang-Tsao, Hungate, Randall W., Jordan, Steven R., Kong, Ke, Liu, Longbin, Michelsen, Klaus, Moyer, Carolyn, Nishimura, Nobuko, Norman, Mark H., Reichelt, Andreas, Siegmund, Aaron C., Sivits, Glenn, Tadesse, Seifu, Tegley, Christopher M., Van, Gwyneth, Yang, Kevin C., Yao, Guomin, Zhang, Jiandong, Lloyd, David J., Hale, Clarence, & St. Jean, Jr., David J. Discovery and Structure-Guided Optimization of Diarylmethanesulfonamide Disrupters of Glucokinase–Glucokinase Regulatory Protein (GK–GKRP) Binding: Strategic Use of a N → S (n N → σ* S–X ) Interaction for Conformational Constraint. United States. https://doi.org/10.1021/acs.jmedchem.5b01367
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Pennington, Lewis D., Bartberger, Michael D., Croghan, Michael D., Andrews, Kristin L., Ashton, Kate S., Bourbeau, Matthew P., Chen, Jie, Chmait, Samer, Cupples, Rod, Fotsch, Christopher, Helmering, Joan, Hong, Fang-Tsao, Hungate, Randall W., Jordan, Steven R., Kong, Ke, Liu, Longbin, Michelsen, Klaus, Moyer, Carolyn, Nishimura, Nobuko, Norman, Mark H., Reichelt, Andreas, Siegmund, Aaron C., Sivits, Glenn, Tadesse, Seifu, Tegley, Christopher M., Van, Gwyneth, Yang, Kevin C., Yao, Guomin, Zhang, Jiandong, Lloyd, David J., Hale, Clarence, and St. Jean, Jr., David J. Tue . "Discovery and Structure-Guided Optimization of Diarylmethanesulfonamide Disrupters of Glucokinase–Glucokinase Regulatory Protein (GK–GKRP) Binding: Strategic Use of a N → S (n N → σ* S–X ) Interaction for Conformational Constraint". United States. https://doi.org/10.1021/acs.jmedchem.5b01367.
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@article{osti_1227324,
title = {Discovery and Structure-Guided Optimization of Diarylmethanesulfonamide Disrupters of Glucokinase–Glucokinase Regulatory Protein (GK–GKRP) Binding: Strategic Use of a N → S (n N → σ* S–X ) Interaction for Conformational Constraint},
author = {Pennington, Lewis D. and Bartberger, Michael D. and Croghan, Michael D. and Andrews, Kristin L. and Ashton, Kate S. and Bourbeau, Matthew P. and Chen, Jie and Chmait, Samer and Cupples, Rod and Fotsch, Christopher and Helmering, Joan and Hong, Fang-Tsao and Hungate, Randall W. and Jordan, Steven R. and Kong, Ke and Liu, Longbin and Michelsen, Klaus and Moyer, Carolyn and Nishimura, Nobuko and Norman, Mark H. and Reichelt, Andreas and Siegmund, Aaron C. and Sivits, Glenn and Tadesse, Seifu and Tegley, Christopher M. and Van, Gwyneth and Yang, Kevin C. and Yao, Guomin and Zhang, Jiandong and Lloyd, David J. and Hale, Clarence and St. Jean, Jr., David J.},
abstractNote = {},
doi = {10.1021/acs.jmedchem.5b01367},
journal = {Journal of Medicinal Chemistry},
number = 24,
volume = 58,
place = {United States},
year = {Tue Dec 01 00:00:00 EST 2015},
month = {Tue Dec 01 00:00:00 EST 2015}
}
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https://doi.org/10.1021/acs.jmedchem.5b01367
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