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Title: The Salmonella type III secretion system virulence effector forms a new hexameric chaperone assembly for export of effector/chaperone complexes

Journal Article · · Journal of Bacteriology
ORCiD logo [1];  [2];  [2];  [1]
  1. Lawrence Berkeley National Laboratory, Berkeley, CA (United States), Life Sciences Division.
  2. University of British Columbia, Vancouver, British Columbia (Canada)
+ Show Author Affiliations

Bacteria hijack eukaryotic cells by injecting virulence effectors into host cytosol with a type III secretion system (T3SS). Effectors are targeted with their cognate chaperones to hexameric T3SS ATPase at the bacterial membrane's cytosolic face. In this issue of the Journal of Bacteriology, Roblin et al. (P. Roblin, F. Dewitte, V. Villeret, E. G. Biondi, and C. Bompard, J Bacteriol 197:688–698, 2015, http://dx.doi.org/10.1128/JB.02294-14) show that the T3SS chaperone SigE of Salmonella can form hexameric rings rather than dimers when bound to its cognate effector, SopB, implying a novel multimeric association for chaperone/effector complexes with their ATPase.

Research Organization:
Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)
Sponsoring Organization:
USDOE
Grant/Contract Number:
AC02-05CH11231
OSTI ID:
1215639
Journal Information:
Journal of Bacteriology, Journal Name: Journal of Bacteriology Journal Issue: 4 Vol. 197; ISSN 0021-9193
Publisher:
American Society for MicrobiologyCopyright Statement
Country of Publication:
United States
Language:
English

References (40)

Assembly and structure of the T3SS journal August 2014
The structural organization of the N-terminus domain of SopB, a virulence factor of Salmonella, depends on the nature of its protein partners journal December 2013
Real-Time Analysis of Effector Translocation by the Type III Secretion System of Enteropathogenic Escherichia coli journal February 2008
Oligomerization of the Bacterial Flagellar ATPase FliI is Controlled by its Extreme N-terminal Region journal July 2006
A Common Structural Motif in the Binding of Virulence Factors to Bacterial Secretion Chaperones journal March 2006
Type IV Pilus Structure by Cryo-Electron Microscopy and Crystallography: Implications for Pilus Assembly and Functions journal September 2006
Insights into FlaI Functions in Archaeal Motor Assembly and Motility from Structures, Conformations, and Genetics journal March 2013
Maintenance of an unfolded polypeptide by a cognate chaperone in bacterial type III secretion journal November 2001
Chaperone release and unfolding of substrates in type III secretion journal October 2005
Accurate assessment of mass, models and resolution by small-angle scattering journal April 2013
An energy transduction mechanism used in bacterial flagellar type III protein export journal September 2011
Comprehensive macromolecular conformations mapped by quantitative SAXS analyses journal April 2013
The type III secretion injectisome journal November 2006
Type IV pilus structure and bacterial pathogenicity journal May 2004
Structural and biochemical characterization of the type III secretion chaperones CesT and SigE journal October 2001
Common architecture of the flagellar type III protein export apparatus and F- and V-type ATPases journal January 2011
Architecture of the major component of the type III secretion system export apparatus journal December 2012
Structure of a pathogenic type 3 secretion system in action journal December 2013
Structural analysis of a prototypical ATPase from the type III secretion system journal January 2007
Common and distinct structural features of Salmonella injectisome and flagellar basal body journal November 2013
Oligomerization and activation of the FliI ATPase central to bacterial flagellum assembly: Flagellar ATPase journal April 2003
Real-time imaging of type III secretion: Salmonella SipA injection into host cells journal August 2005
The inner rod protein controls substrate switching and needle length in a Salmonella type III secretion system journal December 2013
Identification of the Docking Site between a Type III Secretion System ATPase and a Chaperone for Effector Cargo journal July 2014
Type III Protein Translocase: HrcN IS A PERIPHERAL MEMBRANE ATPASE THAT IS ACTIVATED BY OLIGOMERIZATION journal May 2003
Identification of the Docking Site between a Type III Secretion System ATPase and a Chaperone for Effector Cargo journal July 2014
Type III Protein Translocase: HrcN IS A PERIPHERAL MEMBRANE ATPASE THAT IS ACTIVATED BY OLIGOMERIZATION journal May 2003
Functional domains and motifs of bacterial type III effector proteins and their roles in infection journal November 2011
Bacterial Injectisomes: Needle Length Does Matter journal February 2005
YscP and YscU Switch the Substrate Specificity of the Yersinia Type III Secretion System by Regulating Export of the Inner Rod Protein YscI journal April 2008
EscO, a Functional and Structural Analog of the Flagellar FliJ Protein, Is a Positive Regulator of EscN ATPase Activity of the Enteropathogenic Escherichia coli Injectisome journal April 2014
A Salmonella Type Three Secretion Effector/Chaperone Complex Adopts a Hexameric Ring-Like Structure journal November 2014
Genetic Analysis of the Salmonella enterica Type III Secretion-Associated ATPase InvC Defines Discrete Functional Domains journal April 2004
YscP and YscU Switch the Substrate Specificity of the Yersinia Type III Secretion System by Regulating Export of the Inner Rod Protein YscI journal April 2008
EscO, a Functional and Structural Analog of the Flagellar FliJ Protein, Is a Positive Regulator of EscN ATPase Activity of the Enteropathogenic Escherichia coli Injectisome journal April 2014
A Salmonella Type Three Secretion Effector/Chaperone Complex Adopts a Hexameric Ring-Like Structure journal November 2014
Genetic Analysis of the Salmonella enterica Type III Secretion-Associated ATPase InvC Defines Discrete Functional Domains journal April 2004
Dynamics of the Type III Secretion System Activity of Enteropathogenic Escherichia coli journal July 2013
Dynamics of the Type III Secretion System Activity of Enteropathogenic Escherichia coli journal July 2013
Sequence-Based Prediction of Type III Secreted Proteins journal April 2009

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