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Title: Palladium-catalyzed Br/D exchange of arenes: Selective deuterium incorporation with versatile functional group tolerance and high efficiency

There is a facile method for introducing one or more deuterium atoms onto an aromatic nucleus via Br/D exchange with high functional group tolerance and high incorporation efficiency is disclosed. Deuterium-labeled aryl chlorides and aryl borates which could be used as substrates in cross-coupling reactions to construct more complicated deuterium-labeled compounds can also be synthesized by this method.
Authors:
 [1] ;  [1] ;  [1]
  1. Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States). Center for Nanophase Materials Science
Publication Date:
Grant/Contract Number:
AC05-00OR22725
Type:
Accepted Manuscript
Journal Name:
Organic Chemistry Frontiers (Online)
Additional Journal Information:
Journal Name: Organic Chemistry Frontiers (Online); Journal Volume: 2; Journal Issue: 9; Journal ID: ISSN 2052-4129
Publisher:
Royal Society of Chemistry
Research Org:
Oak Ridge National Laboratory (ORNL), Oak Ridge, TN (United States). Center for Nanophase Materials Sciences (CNMS)
Sponsoring Org:
USDOE Office of Science (SC)
Country of Publication:
United States
Language:
English
Subject:
37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY
OSTI Identifier:
1210145

Zhang, Honghai -Hai, Bonnesen, Peter V., and Hong, Kunlun. Palladium-catalyzed Br/D exchange of arenes: Selective deuterium incorporation with versatile functional group tolerance and high efficiency. United States: N. p., Web. doi:10.1039/C5QO00181A.
Zhang, Honghai -Hai, Bonnesen, Peter V., & Hong, Kunlun. Palladium-catalyzed Br/D exchange of arenes: Selective deuterium incorporation with versatile functional group tolerance and high efficiency. United States. doi:10.1039/C5QO00181A.
Zhang, Honghai -Hai, Bonnesen, Peter V., and Hong, Kunlun. 2015. "Palladium-catalyzed Br/D exchange of arenes: Selective deuterium incorporation with versatile functional group tolerance and high efficiency". United States. doi:10.1039/C5QO00181A. https://www.osti.gov/servlets/purl/1210145.
@article{osti_1210145,
title = {Palladium-catalyzed Br/D exchange of arenes: Selective deuterium incorporation with versatile functional group tolerance and high efficiency},
author = {Zhang, Honghai -Hai and Bonnesen, Peter V. and Hong, Kunlun},
abstractNote = {There is a facile method for introducing one or more deuterium atoms onto an aromatic nucleus via Br/D exchange with high functional group tolerance and high incorporation efficiency is disclosed. Deuterium-labeled aryl chlorides and aryl borates which could be used as substrates in cross-coupling reactions to construct more complicated deuterium-labeled compounds can also be synthesized by this method.},
doi = {10.1039/C5QO00181A},
journal = {Organic Chemistry Frontiers (Online)},
number = 9,
volume = 2,
place = {United States},
year = {2015},
month = {7}
}