Neutron Diffraction Reveals Hydrogen Bonds Critical for cGMP-Selective Activation: Insights for cGMP-Dependent Protein Kinase Agonist Design

Journal Article · Wed Oct 22 04:00:00 UTC 2014 · Biochemistry

DOI: https://doi.org/10.1021/bi501012v · OSTI ID:1163250

Huang, Gilbert Y. ^[1]; Gerlits, Oksana O. ^[2]; Blakeley, Matthew P. ^[3]; Sankaran, Banumathi ^[4]; Kovalevsky, Andrey Y. ^[2]; Kim, Choel ^[5]

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1. Verna and Mars McClean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77004, United States
2. Biology and Soft Matter Division, Oak Ridge National Laboratory, Oak Ridge, Tennessee 37831, United States
3. Institute Laue-Langevin, 71 Avenue des Martyrs, 38000, Grenoble, France
4. Berkeley Center for Structural Biology, Lawrence Berkeley National Laboratory, Berkeley, California, United States
5. Verna and Mars McClean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77004, United States, Department of Pharmacology, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77004, United States

Not Available

• Sponsoring Organization: USDOE Office of Science (SC), Basic Energy Sciences (BES)
• OSTI ID: 1163250
• Journal Information: Biochemistry, Journal Name: Biochemistry Journal Issue: 43 Vol. 53; ISSN 0006-2960
• Publisher: American Chemical SocietyCopyright Statement
• Country of Publication: United States
• Language: English