Abstract
An 11 gold atom (undecagold) cluster was covalently attached to specific sites on Fab', F(ab'){sub 2} and whole IgG molecules such that each carried 11-33 gold atoms without significant loss of native immunospecificity. Gold cluster labeled 17-1A monoclonal F(ab'){sub 2} antibody fragments showed 80% immunoreactivity compared to native antibody fragments in binding to human colon carcinoma cells in vitro. Radioactive gold in vivo biodistribution in nude mice with human tumors are also reported. By using clusters, potentially a larger destructive payload can be carried per antibody. (author).
Hainfeld, J F;
Foley, C J;
Srivastava, S C;
Mausner, L F;
Feng, N I;
Meinken, G E;
Steplewski, Z
[1]
- Brookhaven National Lab., Upton, NY (USA) Wistar Inst. of Anatomy and Biology, Philadelphia, PA (USA)
Citation Formats
Hainfeld, J F, Foley, C J, Srivastava, S C, Mausner, L F, Feng, N I, Meinken, G E, and Steplewski, Z.
Radioactive gold cluster immunoconjugates: potential agents for cancer therapy.
United Kingdom: N. p.,
1990.
Web.
doi:10.1016/0883-2897(90)90054-5.
Hainfeld, J F, Foley, C J, Srivastava, S C, Mausner, L F, Feng, N I, Meinken, G E, & Steplewski, Z.
Radioactive gold cluster immunoconjugates: potential agents for cancer therapy.
United Kingdom.
https://doi.org/10.1016/0883-2897(90)90054-5
Hainfeld, J F, Foley, C J, Srivastava, S C, Mausner, L F, Feng, N I, Meinken, G E, and Steplewski, Z.
1990.
"Radioactive gold cluster immunoconjugates: potential agents for cancer therapy."
United Kingdom.
https://doi.org/10.1016/0883-2897(90)90054-5.
@misc{etde_6640736,
title = {Radioactive gold cluster immunoconjugates: potential agents for cancer therapy}
author = {Hainfeld, J F, Foley, C J, Srivastava, S C, Mausner, L F, Feng, N I, Meinken, G E, and Steplewski, Z}
abstractNote = {An 11 gold atom (undecagold) cluster was covalently attached to specific sites on Fab', F(ab'){sub 2} and whole IgG molecules such that each carried 11-33 gold atoms without significant loss of native immunospecificity. Gold cluster labeled 17-1A monoclonal F(ab'){sub 2} antibody fragments showed 80% immunoreactivity compared to native antibody fragments in binding to human colon carcinoma cells in vitro. Radioactive gold in vivo biodistribution in nude mice with human tumors are also reported. By using clusters, potentially a larger destructive payload can be carried per antibody. (author).}
doi = {10.1016/0883-2897(90)90054-5}
journal = []
volume = {17:3}
journal type = {AC}
place = {United Kingdom}
year = {1990}
month = {Jan}
}
title = {Radioactive gold cluster immunoconjugates: potential agents for cancer therapy}
author = {Hainfeld, J F, Foley, C J, Srivastava, S C, Mausner, L F, Feng, N I, Meinken, G E, and Steplewski, Z}
abstractNote = {An 11 gold atom (undecagold) cluster was covalently attached to specific sites on Fab', F(ab'){sub 2} and whole IgG molecules such that each carried 11-33 gold atoms without significant loss of native immunospecificity. Gold cluster labeled 17-1A monoclonal F(ab'){sub 2} antibody fragments showed 80% immunoreactivity compared to native antibody fragments in binding to human colon carcinoma cells in vitro. Radioactive gold in vivo biodistribution in nude mice with human tumors are also reported. By using clusters, potentially a larger destructive payload can be carried per antibody. (author).}
doi = {10.1016/0883-2897(90)90054-5}
journal = []
volume = {17:3}
journal type = {AC}
place = {United Kingdom}
year = {1990}
month = {Jan}
}