Radioactive gold cluster immunoconjugates: potential agents for cancer therapy Hainfeld, J F; Foley, C J; Srivastava, S C; Mausner, L F; Feng, N I; Meinken, G E; Steplewski, Z [Brookhaven National Lab., Upton, NY (USA) Wistar Inst. of Anatomy and Biology, Philadelphia, PA (USA)] 62 RADIOLOGY AND NUCLEAR MEDICINE; MONOCLONAL ANTIBODIES; GOLD 199; RADIOPHARMACEUTICALS; NEOPLASMS; IN VIVO; MICE; RADIOIMMUNOASSAY; RADIOTHERAPY; TISSUE DISTRIBUTION; ANIMALS; ANTIBODIES; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BIOASSAY; DAYS LIVING RADIOISOTOPES; DIAGNOSTIC TECHNIQUES; DISEASES; DISTRIBUTION; DRUGS; GOLD ISOTOPES; HEAVY NUCLEI; IMMUNOASSAY; IMMUNOLOGY; ISOTOPE APPLICATIONS; ISOTOPES; LABELLED COMPOUNDS; MAMMALS; MEDICINE; NUCLEAR MEDICINE; NUCLEI; ODD-EVEN NUCLEI; RADIOASSAY; RADIOIMMUNODETECTION; RADIOIMMUNOLOGY; RADIOISOTOPES; RADIOLOGY; RODENTS; THERAPY; TRACER TECHNIQUES; VERTEBRATES; 550604* - Medicine- Unsealed Radionuclides in Therapy- (1980-) An 11 gold atom (undecagold) cluster was covalently attached to specific sites on Fab', F(ab'){sub 2} and whole IgG molecules such that each carried 11-33 gold atoms without significant loss of native immunospecificity. Gold cluster labeled 17-1A monoclonal F(ab'){sub 2} antibody fragments showed 80% immunoreactivity compared to native antibody fragments in binding to human colon carcinoma cells in vitro. Radioactive gold in vivo biodistribution in nude mice with human tumors are also reported. By using clusters, potentially a larger destructive payload can be carried per antibody. (author). United Kingdom 1990-01-01 English Journal Article Journal Name: Nuclear Medicine and Biology; (UK); Journal Volume: 17:3 Medium: X; Size: Pages: 287-294 https://doi.org/10.1016/0883-2897(90)90054-5 CNN: GM 31975; CA 21124 [] 17:3 Journal ID: ISSN 0883-2897; CODEN: NMBIE; Other: CNN: GM 31975; CA 21124 GBN; AIX-21-075598; EDB-90-142530 2010-12-30 6640736