Abstract
Immobilizing organic–inorganic hybrid composites onto the implant surface is a promising strategy to improve host acceptance of the implant. The objective of this present study was to obtain a unique macroporous titanium-surface with the organic–mineral composite coatings consisting of gelatin methacrylate hydrogel (GelMA) and hydroxyapatite (HA). A 3-(trimethoxysilyl) propyl methacrylate (TMSPMA) layer was first coated onto the titanium surface, and surface was then covalently functionalized with GelMA using a photochemical method. Mineralization of the GelMA coating on the titanium surface was subsequently carried out by a biomimetic method. After 3-day mineralization, a large number of mineral phases comprising spherical amorphous nanoparticles were found randomly deposited inside GelMA matrix. The resulting mineralized hydrogel composites exhibited a unique rough surface of macroporous structure. The structure of the prepared GelMA/HA composite coating was studied by field emission scanning electron microscopy (FESEM), energy dispersive X-ray spectra (EDS), attenuated total refraction Fourier transform infrared spectroscopy (ATR-FTIR), X-ray photoelectron spectroscopy (XPS) and X-ray diffraction (XRD). Water contact angle measurement revealed the hydrophilicity properties of composite coatings. GelMA/HA on titanium after the TMSPMA treatment is very stable when tested in vitro with a PBS solution at 37 °C, due to the role of TMSPMA as a molecular
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Tan, Guoxin;
[1]
Zhou, Lei;
[1]
Ning, Chengyun;
[2]
Tan, Ying;
[1]
Ni, Guoxin;
[3]
Liao, Jingwen;
Yu, Peng;
Chen, Xiaofeng
[2]
- School of Chemical Engineering and Light Industry, Guangdong University of Technology, Guangzhou, 510006 (China)
- College of Materials Science and Technology, South China University of Technology, Guangzhou, 510641 (China)
- Department of Orthopedics and Traumatology, Nanfang Hospital, Southern Medical University, Guangzhou, 510515 (China)
Citation Formats
Tan, Guoxin, Zhou, Lei, Ning, Chengyun, Tan, Ying, Ni, Guoxin, Liao, Jingwen, Yu, Peng, and Chen, Xiaofeng.
Biomimetically-mineralized composite coatings on titanium functionalized with gelatin methacrylate hydrogels.
Netherlands: N. p.,
2013.
Web.
doi:10.1016/J.APSUSC.2013.04.088.
Tan, Guoxin, Zhou, Lei, Ning, Chengyun, Tan, Ying, Ni, Guoxin, Liao, Jingwen, Yu, Peng, & Chen, Xiaofeng.
Biomimetically-mineralized composite coatings on titanium functionalized with gelatin methacrylate hydrogels.
Netherlands.
https://doi.org/10.1016/J.APSUSC.2013.04.088
Tan, Guoxin, Zhou, Lei, Ning, Chengyun, Tan, Ying, Ni, Guoxin, Liao, Jingwen, Yu, Peng, and Chen, Xiaofeng.
2013.
"Biomimetically-mineralized composite coatings on titanium functionalized with gelatin methacrylate hydrogels."
Netherlands.
https://doi.org/10.1016/J.APSUSC.2013.04.088.
@misc{etde_22297177,
title = {Biomimetically-mineralized composite coatings on titanium functionalized with gelatin methacrylate hydrogels}
author = {Tan, Guoxin, Zhou, Lei, Ning, Chengyun, Tan, Ying, Ni, Guoxin, Liao, Jingwen, Yu, Peng, and Chen, Xiaofeng}
abstractNote = {Immobilizing organic–inorganic hybrid composites onto the implant surface is a promising strategy to improve host acceptance of the implant. The objective of this present study was to obtain a unique macroporous titanium-surface with the organic–mineral composite coatings consisting of gelatin methacrylate hydrogel (GelMA) and hydroxyapatite (HA). A 3-(trimethoxysilyl) propyl methacrylate (TMSPMA) layer was first coated onto the titanium surface, and surface was then covalently functionalized with GelMA using a photochemical method. Mineralization of the GelMA coating on the titanium surface was subsequently carried out by a biomimetic method. After 3-day mineralization, a large number of mineral phases comprising spherical amorphous nanoparticles were found randomly deposited inside GelMA matrix. The resulting mineralized hydrogel composites exhibited a unique rough surface of macroporous structure. The structure of the prepared GelMA/HA composite coating was studied by field emission scanning electron microscopy (FESEM), energy dispersive X-ray spectra (EDS), attenuated total refraction Fourier transform infrared spectroscopy (ATR-FTIR), X-ray photoelectron spectroscopy (XPS) and X-ray diffraction (XRD). Water contact angle measurement revealed the hydrophilicity properties of composite coatings. GelMA/HA on titanium after the TMSPMA treatment is very stable when tested in vitro with a PBS solution at 37 °C, due to the role of TMSPMA as a molecular bridge. It was expected that the macroporous GelMA/HA composite coatings might potentially promote and accelerate titanium (Ti)-based implants osseointegration for bone repair and regeneration.}
doi = {10.1016/J.APSUSC.2013.04.088}
journal = []
volume = {279}
journal type = {AC}
place = {Netherlands}
year = {2013}
month = {Aug}
}
title = {Biomimetically-mineralized composite coatings on titanium functionalized with gelatin methacrylate hydrogels}
author = {Tan, Guoxin, Zhou, Lei, Ning, Chengyun, Tan, Ying, Ni, Guoxin, Liao, Jingwen, Yu, Peng, and Chen, Xiaofeng}
abstractNote = {Immobilizing organic–inorganic hybrid composites onto the implant surface is a promising strategy to improve host acceptance of the implant. The objective of this present study was to obtain a unique macroporous titanium-surface with the organic–mineral composite coatings consisting of gelatin methacrylate hydrogel (GelMA) and hydroxyapatite (HA). A 3-(trimethoxysilyl) propyl methacrylate (TMSPMA) layer was first coated onto the titanium surface, and surface was then covalently functionalized with GelMA using a photochemical method. Mineralization of the GelMA coating on the titanium surface was subsequently carried out by a biomimetic method. After 3-day mineralization, a large number of mineral phases comprising spherical amorphous nanoparticles were found randomly deposited inside GelMA matrix. The resulting mineralized hydrogel composites exhibited a unique rough surface of macroporous structure. The structure of the prepared GelMA/HA composite coating was studied by field emission scanning electron microscopy (FESEM), energy dispersive X-ray spectra (EDS), attenuated total refraction Fourier transform infrared spectroscopy (ATR-FTIR), X-ray photoelectron spectroscopy (XPS) and X-ray diffraction (XRD). Water contact angle measurement revealed the hydrophilicity properties of composite coatings. GelMA/HA on titanium after the TMSPMA treatment is very stable when tested in vitro with a PBS solution at 37 °C, due to the role of TMSPMA as a molecular bridge. It was expected that the macroporous GelMA/HA composite coatings might potentially promote and accelerate titanium (Ti)-based implants osseointegration for bone repair and regeneration.}
doi = {10.1016/J.APSUSC.2013.04.088}
journal = []
volume = {279}
journal type = {AC}
place = {Netherlands}
year = {2013}
month = {Aug}
}