Abstract
Objective: To assess the continuous process of nerve regeneration in acute peripheral nerve traction injury treated with mesenchymal stem cells (MSCs) transplantation using MRI. Materials and methods: 1 week after acute nerve traction injury was established in the sciatic nerve of 48 New Zealand white rabbits, 5 × 10{sup 5} MSCs and vehicle alone were grafted to the acutely distracted sciatic nerves each in 24 animals. Serial MRI and T1 and T2 measurements of the injured nerves were performed with a 1.5-T scanner and functional recovery was recorded over a 10-week follow-up period, with histological assessments performed at regular intervals. Results: Compared with vehicle control, nerves grafted with MSCs had better functional recovery and showed improved nerve regeneration, with a sustained increase of T1 and T2 values during the phase of regeneration. Conclusion: MRI could be used to monitor the enhanced nerve regeneration in acute peripheral nerve traction injury treated with MSC transplantation, reflected by a prolonged increase in T1 and T2 values of the injured nerves.
Duan, Xiao-Hui;
[1]
Cheng, Li-Na;
[1]
Zhang, Fang;
[1]
Liu, Jun;
[2]
Guo, Ruo-Mi;
[1]
Zhong, Xiao-Mei;
[1]
Wen, Xue-Hua;
[1]
Shen, Jun
[1]
- Department of Radiology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, No. 107 Yanjiang Road West, Guangzhou 510120, Guangdong (China)
- Department of Neurology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, No. 107 Yanjiang Road West, Guangzhou 510120, Guangdong (China)
Citation Formats
Duan, Xiao-Hui, Cheng, Li-Na, Zhang, Fang, Liu, Jun, Guo, Ruo-Mi, Zhong, Xiao-Mei, Wen, Xue-Hua, and Shen, Jun.
In vivo MRI monitoring nerve regeneration of acute peripheral nerve traction injury following mesenchymal stem cell transplantation.
Netherlands: N. p.,
2012.
Web.
doi:10.1016/J.EJRAD.2011.06.050.
Duan, Xiao-Hui, Cheng, Li-Na, Zhang, Fang, Liu, Jun, Guo, Ruo-Mi, Zhong, Xiao-Mei, Wen, Xue-Hua, & Shen, Jun.
In vivo MRI monitoring nerve regeneration of acute peripheral nerve traction injury following mesenchymal stem cell transplantation.
Netherlands.
https://doi.org/10.1016/J.EJRAD.2011.06.050
Duan, Xiao-Hui, Cheng, Li-Na, Zhang, Fang, Liu, Jun, Guo, Ruo-Mi, Zhong, Xiao-Mei, Wen, Xue-Hua, and Shen, Jun.
2012.
"In vivo MRI monitoring nerve regeneration of acute peripheral nerve traction injury following mesenchymal stem cell transplantation."
Netherlands.
https://doi.org/10.1016/J.EJRAD.2011.06.050.
@misc{etde_22267518,
title = {In vivo MRI monitoring nerve regeneration of acute peripheral nerve traction injury following mesenchymal stem cell transplantation}
author = {Duan, Xiao-Hui, Cheng, Li-Na, Zhang, Fang, Liu, Jun, Guo, Ruo-Mi, Zhong, Xiao-Mei, Wen, Xue-Hua, and Shen, Jun}
abstractNote = {Objective: To assess the continuous process of nerve regeneration in acute peripheral nerve traction injury treated with mesenchymal stem cells (MSCs) transplantation using MRI. Materials and methods: 1 week after acute nerve traction injury was established in the sciatic nerve of 48 New Zealand white rabbits, 5 × 10{sup 5} MSCs and vehicle alone were grafted to the acutely distracted sciatic nerves each in 24 animals. Serial MRI and T1 and T2 measurements of the injured nerves were performed with a 1.5-T scanner and functional recovery was recorded over a 10-week follow-up period, with histological assessments performed at regular intervals. Results: Compared with vehicle control, nerves grafted with MSCs had better functional recovery and showed improved nerve regeneration, with a sustained increase of T1 and T2 values during the phase of regeneration. Conclusion: MRI could be used to monitor the enhanced nerve regeneration in acute peripheral nerve traction injury treated with MSC transplantation, reflected by a prolonged increase in T1 and T2 values of the injured nerves.}
doi = {10.1016/J.EJRAD.2011.06.050}
journal = []
issue = {9}
volume = {81}
journal type = {AC}
place = {Netherlands}
year = {2012}
month = {Sep}
}
title = {In vivo MRI monitoring nerve regeneration of acute peripheral nerve traction injury following mesenchymal stem cell transplantation}
author = {Duan, Xiao-Hui, Cheng, Li-Na, Zhang, Fang, Liu, Jun, Guo, Ruo-Mi, Zhong, Xiao-Mei, Wen, Xue-Hua, and Shen, Jun}
abstractNote = {Objective: To assess the continuous process of nerve regeneration in acute peripheral nerve traction injury treated with mesenchymal stem cells (MSCs) transplantation using MRI. Materials and methods: 1 week after acute nerve traction injury was established in the sciatic nerve of 48 New Zealand white rabbits, 5 × 10{sup 5} MSCs and vehicle alone were grafted to the acutely distracted sciatic nerves each in 24 animals. Serial MRI and T1 and T2 measurements of the injured nerves were performed with a 1.5-T scanner and functional recovery was recorded over a 10-week follow-up period, with histological assessments performed at regular intervals. Results: Compared with vehicle control, nerves grafted with MSCs had better functional recovery and showed improved nerve regeneration, with a sustained increase of T1 and T2 values during the phase of regeneration. Conclusion: MRI could be used to monitor the enhanced nerve regeneration in acute peripheral nerve traction injury treated with MSC transplantation, reflected by a prolonged increase in T1 and T2 values of the injured nerves.}
doi = {10.1016/J.EJRAD.2011.06.050}
journal = []
issue = {9}
volume = {81}
journal type = {AC}
place = {Netherlands}
year = {2012}
month = {Sep}
}