Abstract
A bone substitute material was developed consisting of a chitosan oligosaccharide (COS) solution in a liquid phase and gelatin (GLT) containing calcium phosphate powder in a solid phase. The physicochemical and biocompatible properties of the hybrid cements were evaluated. The addition of COS to cement did not affect the setting time or diametral tensile strength of the hybrid cements, whereas GLT significantly prolonged the setting time and decreased the strength slightly. The setting reaction was inhibited by the addition of GLT to the initial mixture, but not by COS. However, the presence of GLT appreciably improved the anti-washout properties of the hybrid cement compared with COS. COS may promote the cement's biocompatibility as an approximate twofold increase in cell proliferation for 10% COS-containing cements was observed on day 3 as compared with the controls. The combination of GLT and COS was chosen due to the benefits achieved from several synergistic effects and for their clinical applications. Cement with 5% GLT and 10% COS may be a better choice among cements in terms of anti-washout properties and biological activity.
Chiang, Ting-Yi;
[1]
Ho, Chia-Che;
[2]
Chen, David Chan-Hen;
[3]
Lai, Meng-Heng;
[2]
Ding, Shinn-Jyh;
[2]
Department of Dentistry, Chung-Shan Medical University Hospital, Taichung 402, Taiwan (China)]
- Department of Dental Laboratory Technology, Central Taiwan University of Science and Technology, Taichung 406, Taiwan (China)
- Institute of Oral Biology and Biomaterials Science, Chung-Shan Medical University, Taichung 402, Taiwan (China)
- Institute of Veterinary Microbiology, National Chung-Hsing University, Taichung 402, Taiwan (China)
Citation Formats
Chiang, Ting-Yi, Ho, Chia-Che, Chen, David Chan-Hen, Lai, Meng-Heng, Ding, Shinn-Jyh, and Department of Dentistry, Chung-Shan Medical University Hospital, Taichung 402, Taiwan (China)].
Physicochemical properties and biocompatibility of chitosan oligosaccharide/gelatin/calcium phosphate hybrid cements.
Netherlands: N. p.,
2010.
Web.
doi:10.1016/J.MATCHEMPHYS.2009.11.007.
Chiang, Ting-Yi, Ho, Chia-Che, Chen, David Chan-Hen, Lai, Meng-Heng, Ding, Shinn-Jyh, & Department of Dentistry, Chung-Shan Medical University Hospital, Taichung 402, Taiwan (China)].
Physicochemical properties and biocompatibility of chitosan oligosaccharide/gelatin/calcium phosphate hybrid cements.
Netherlands.
https://doi.org/10.1016/J.MATCHEMPHYS.2009.11.007
Chiang, Ting-Yi, Ho, Chia-Che, Chen, David Chan-Hen, Lai, Meng-Heng, Ding, Shinn-Jyh, and Department of Dentistry, Chung-Shan Medical University Hospital, Taichung 402, Taiwan (China)].
2010.
"Physicochemical properties and biocompatibility of chitosan oligosaccharide/gelatin/calcium phosphate hybrid cements."
Netherlands.
https://doi.org/10.1016/J.MATCHEMPHYS.2009.11.007.
@misc{etde_22060866,
title = {Physicochemical properties and biocompatibility of chitosan oligosaccharide/gelatin/calcium phosphate hybrid cements}
author = {Chiang, Ting-Yi, Ho, Chia-Che, Chen, David Chan-Hen, Lai, Meng-Heng, Ding, Shinn-Jyh, and Department of Dentistry, Chung-Shan Medical University Hospital, Taichung 402, Taiwan (China)]}
abstractNote = {A bone substitute material was developed consisting of a chitosan oligosaccharide (COS) solution in a liquid phase and gelatin (GLT) containing calcium phosphate powder in a solid phase. The physicochemical and biocompatible properties of the hybrid cements were evaluated. The addition of COS to cement did not affect the setting time or diametral tensile strength of the hybrid cements, whereas GLT significantly prolonged the setting time and decreased the strength slightly. The setting reaction was inhibited by the addition of GLT to the initial mixture, but not by COS. However, the presence of GLT appreciably improved the anti-washout properties of the hybrid cement compared with COS. COS may promote the cement's biocompatibility as an approximate twofold increase in cell proliferation for 10% COS-containing cements was observed on day 3 as compared with the controls. The combination of GLT and COS was chosen due to the benefits achieved from several synergistic effects and for their clinical applications. Cement with 5% GLT and 10% COS may be a better choice among cements in terms of anti-washout properties and biological activity.}
doi = {10.1016/J.MATCHEMPHYS.2009.11.007}
journal = []
issue = {2-3}
volume = {120}
journal type = {AC}
place = {Netherlands}
year = {2010}
month = {Apr}
}
title = {Physicochemical properties and biocompatibility of chitosan oligosaccharide/gelatin/calcium phosphate hybrid cements}
author = {Chiang, Ting-Yi, Ho, Chia-Che, Chen, David Chan-Hen, Lai, Meng-Heng, Ding, Shinn-Jyh, and Department of Dentistry, Chung-Shan Medical University Hospital, Taichung 402, Taiwan (China)]}
abstractNote = {A bone substitute material was developed consisting of a chitosan oligosaccharide (COS) solution in a liquid phase and gelatin (GLT) containing calcium phosphate powder in a solid phase. The physicochemical and biocompatible properties of the hybrid cements were evaluated. The addition of COS to cement did not affect the setting time or diametral tensile strength of the hybrid cements, whereas GLT significantly prolonged the setting time and decreased the strength slightly. The setting reaction was inhibited by the addition of GLT to the initial mixture, but not by COS. However, the presence of GLT appreciably improved the anti-washout properties of the hybrid cement compared with COS. COS may promote the cement's biocompatibility as an approximate twofold increase in cell proliferation for 10% COS-containing cements was observed on day 3 as compared with the controls. The combination of GLT and COS was chosen due to the benefits achieved from several synergistic effects and for their clinical applications. Cement with 5% GLT and 10% COS may be a better choice among cements in terms of anti-washout properties and biological activity.}
doi = {10.1016/J.MATCHEMPHYS.2009.11.007}
journal = []
issue = {2-3}
volume = {120}
journal type = {AC}
place = {Netherlands}
year = {2010}
month = {Apr}
}