{
  "date" : "2010-04-15",
  "identifier_doecontract" : "",
  "subject" : "36 MATERIALS SCIENCE; 60 APPLIED LIFE SCIENCES; AMINO ACIDS; APPROXIMATIONS; BIOLOGICAL MATERIALS; CALCIUM PHOSPHATES; CELL PROLIFERATION; CEMENTS; CERAMICS; COMPOSITE MATERIALS; GELATIN; OLIGOSACCHARIDES; POWDERS; SKELETON; SOLIDS; TENSILE PROPERTIES",
  "description" : "A bone substitute material was developed consisting of a chitosan oligosaccharide (COS) solution in a liquid phase and gelatin (GLT) containing calcium phosphate powder in a solid phase. The physicochemical and biocompatible properties of the hybrid cements were evaluated. The addition of COS to cement did not affect the setting time or diametral tensile strength of the hybrid cements, whereas GLT significantly prolonged the setting time and decreased the strength slightly. The setting reaction was inhibited by the addition of GLT to the initial mixture, but not by COS. However, the presence of GLT appreciably improved the anti-washout properties of the hybrid cement compared with COS. COS may promote the cement's biocompatibility as an approximate twofold increase in cell proliferation for 10% COS-containing cements was observed on day 3 as compared with the controls. The combination of GLT and COS was chosen due to the benefits achieved from several synergistic effects and for their clinical applications. Cement with 5% GLT and 10% COS may be a better choice among cements in terms of anti-washout properties and biological activity.",
  "language" : "English",
  "identifier_report" : "",
  "publisher_sponsor" : "",
  "publisher_country" : "Netherlands",
  "source" : "NLN",
  "purl" : "",
  "title" : "Physicochemical properties and biocompatibility of chitosan oligosaccharide/gelatin/calcium phosphate hybrid cements",
  "type" : "Journal Article",
  "subject_related" : "",
  "relation" : "Journal Name: Materials Chemistry and Physics; Journal Volume: 120; Journal Issue: 2-3; Other Information: Copyright (c) 2009 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.; Country of input: International Atomic Energy Agency (IAEA)",
  "entry_date" : "2013-04-12",
  "subject_list" : [ "36 MATERIALS SCIENCE", "60 APPLIED LIFE SCIENCES", "AMINO ACIDS", "APPROXIMATIONS", "BIOLOGICAL MATERIALS", "CALCIUM PHOSPHATES", "CELL PROLIFERATION", "CEMENTS", "CERAMICS", "COMPOSITE MATERIALS", "GELATIN", "OLIGOSACCHARIDES", "POWDERS", "SKELETON", "SOLIDS", "TENSILE PROPERTIES" ],
  "publisher_availability" : "Available from http://dx.doi.org/10.1016/j.matchemphys.2009.11.007",
  "rights" : "",
  "announced_date" : "2013-03-07",
  "type_qualifier" : "",
  "has_fulltext" : false,
  "coverage" : "",
  "identifier" : "PII: S0254-0584(09)00686-5",
  "journal_volume" : "120",
  "creator" : "Chiang, Ting-Yi [Department of Dental Laboratory Technology, Central Taiwan University of Science and Technology, Taichung 406, Taiwan (China)]; Ho, Chia-Che [Institute of Oral Biology and Biomaterials Science, Chung-Shan Medical University, Taichung 402, Taiwan (China)]; Chen, David Chan-Hen [Institute of Veterinary Microbiology, National Chung-Hsing University, Taichung 402, Taiwan (China)]; Lai, Meng-Heng [Institute of Oral Biology and Biomaterials Science, Chung-Shan Medical University, Taichung 402, Taiwan (China)]; Ding, Shinn-Jyh [Institute of Oral Biology and Biomaterials Science, Chung-Shan Medical University, Taichung 402, Taiwan (China)]; Department of Dentistry, Chung-Shan Medical University Hospital, Taichung 402, Taiwan (China)]",
  "site_ownership_code" : "NLN",
  "osti_id" : "22060866",
  "journal_issue" : "2-3",
  "resource_type" : "JOUR",
  "format" : "Medium: X; Size: page(s) 282-288",
  "journal_name" : [ ],
  "contributing_organizations" : "",
  "citation_location" : "https://www.osti.gov/etdeweb/biblio/22060866",
  "publication_year" : 2010,
  "subject_list_commas" : "36 MATERIALS SCIENCE, 60 APPLIED LIFE SCIENCES, AMINO ACIDS, APPROXIMATIONS, BIOLOGICAL MATERIALS, CALCIUM PHOSPHATES, CELL PROLIFERATION, CEMENTS, CERAMICS, COMPOSITE MATERIALS, GELATIN, OLIGOSACCHARIDES, POWDERS, SKELETON, SOLIDS, TENSILE PROPERTIES",
  "publisher" : "",
  "identifier_other" : "Journal ID: ISSN 0254-0584; CODEN: MCHPDR; Other: PII: S0254-0584(09)00686-5; TRN: NL10R4188020054",
  "publisher_research" : "",
  "creators_list" : [ "Chiang, Ting-Yi [Department of Dental Laboratory Technology, Central Taiwan University of Science and Technology, Taichung 406, Taiwan (China)]", "Ho, Chia-Che [Institute of Oral Biology and Biomaterials Science, Chung-Shan Medical University, Taichung 402, Taiwan (China)]", "Chen, David Chan-Hen [Institute of Veterinary Microbiology, National Chung-Hsing University, Taichung 402, Taiwan (China)]", "Lai, Meng-Heng [Institute of Oral Biology and Biomaterials Science, Chung-Shan Medical University, Taichung 402, Taiwan (China)]", "Ding, Shinn-Jyh [Institute of Oral Biology and Biomaterials Science, Chung-Shan Medical University, Taichung 402, Taiwan (China)]", "Department of Dentistry, Chung-Shan Medical University Hospital, Taichung 402, Taiwan (China)]" ],
  "doi" : "https://doi.org/10.1016/J.MATCHEMPHYS.2009.11.007"
}