Method for determining surface properties of microparticles
Abstract
Second harmonic generation (SHG), sum frequency generation (SFG) and difference frequency generation (DFG) can be used for surface analysis or characterization of microparticles having a non-metallic surface feature. The microparticles can be centrosymmetric or such that non-metallic molecules of interest are centrosymmetrically distributed inside and outside the microparticles but not at the surface of the microparticles where the asymmetry aligns the molecules. The signal is quadratic in incident laser intensity or proportional to the product of two incident laser intensities for SFG, it is sharply peaked at the second harmonic wavelength, quadratic in the density of molecules adsorbed onto the microparticle surface, and linear in microparticles density. In medical or pharmacological applications, molecules of interest may be of drugs or toxins, for example.
- Inventors:
-
- Ridgewood, NJ
- Issue Date:
- Research Org.:
- Columbia Univ., New York, NY (United States)
- OSTI Identifier:
- 872968
- Patent Number(s):
- 6055051
- Assignee:
- Trustees of Columbia University in City of New York (New York, NY)
- Patent Classifications (CPCs):
-
G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- DOE Contract Number:
- FG02-91ER14226
- Resource Type:
- Patent
- Country of Publication:
- United States
- Language:
- English
- Subject:
- method; determining; surface; properties; microparticles; harmonic; generation; shg; frequency; sfg; difference; dfg; analysis; characterization; non-metallic; feature; centrosymmetric; molecules; centrosymmetrically; distributed; inside; outside; asymmetry; aligns; signal; quadratic; incident; laser; intensity; proportional; product; intensities; sharply; peaked; wavelength; density; adsorbed; microparticle; linear; medical; pharmacological; applications; drugs; toxins; example; surface feature; incident laser; surface properties; difference frequency; surface analysis; laser intensities; frequency generation; harmonic generation; particle surface; metallic surface; determining surface; /356/
Citation Formats
Eisenthal, Kenneth B. Method for determining surface properties of microparticles. United States: N. p., 2000.
Web.
Eisenthal, Kenneth B. Method for determining surface properties of microparticles. United States.
Eisenthal, Kenneth B. Sat .
"Method for determining surface properties of microparticles". United States. https://www.osti.gov/servlets/purl/872968.
@article{osti_872968,
title = {Method for determining surface properties of microparticles},
author = {Eisenthal, Kenneth B},
abstractNote = {Second harmonic generation (SHG), sum frequency generation (SFG) and difference frequency generation (DFG) can be used for surface analysis or characterization of microparticles having a non-metallic surface feature. The microparticles can be centrosymmetric or such that non-metallic molecules of interest are centrosymmetrically distributed inside and outside the microparticles but not at the surface of the microparticles where the asymmetry aligns the molecules. The signal is quadratic in incident laser intensity or proportional to the product of two incident laser intensities for SFG, it is sharply peaked at the second harmonic wavelength, quadratic in the density of molecules adsorbed onto the microparticle surface, and linear in microparticles density. In medical or pharmacological applications, molecules of interest may be of drugs or toxins, for example.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Sat Jan 01 00:00:00 EST 2000},
month = {Sat Jan 01 00:00:00 EST 2000}
}