Biomimetic peptoid polymers

Zuckermann, Ronald N.; Chu, Tammy K.; Nam, Ki Tae

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A - human necessities
A01 - agriculture
A21 - baking
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Title: Biomimetic peptoid polymers

Abstract

The present invention provides for novel peptoid oligomers that are capable of self-assembling into two-dimensional sheet structures. The peptoid oligomers can have alternately hydrophilic or polar side-chains and hydrophobic or apolar side-chains. The peptoid oligomers, and the two-dimensional sheet structures, can be applied to biological applications where the peptoid plays a role as a biological scaffold or building block. Also, the two-dimensional sheet structures of the present invention can be used as two-dimensional nanostructures in device applications.

Inventors:: Zuckermann, Ronald N.; Chu, Tammy K.; Nam, Ki Tae

Issue Date:: Tue Jul 07 00:00:00 EDT 2015

Research Org.:: Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)

Sponsoring Org.:: USDOE

OSTI Identifier:: 1190920

Patent Number(s):: 9073977

Application Number:: 13/022,548

Assignee:: The Regents of the University of California (Oakland, CA)

Patent Classifications (CPCs):: C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07K - PEPTIDES

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C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07K - PEPTIDES
C07K1/13 - Labelling of peptides
C07K14/001 - {by chemical synthesis}
C07K7/06 - having 5 to 11 amino acids
C07K7/08 - having 12 to 20 amino acids

Show less

DOE Contract Number:: AC02-05CH11231

Resource Type:: Patent

Resource Relation:: Patent File Date: 2011 Feb 07

Country of Publication:: United States

Language:: English

Subject:: 59 BASIC BIOLOGICAL SCIENCES; 37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY; 77 NANOSCIENCE AND NANOTECHNOLOGY

Citation Formats


                    Zuckermann, Ronald N., Chu, Tammy K., and Nam, Ki Tae. Biomimetic peptoid polymers.  United States: N. p., 2015. 
        Web.

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                    Zuckermann, Ronald N., Chu, Tammy K., & Nam, Ki Tae. Biomimetic peptoid polymers.  United States.

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                    Zuckermann, Ronald N., Chu, Tammy K., and Nam, Ki Tae. Tue .  
        "Biomimetic peptoid polymers".  United States.  https://www.osti.gov/servlets/purl/1190920.

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@article{osti_1190920,

  title        = {Biomimetic peptoid polymers},

  author       = {Zuckermann, Ronald N. and Chu, Tammy K. and Nam, Ki Tae},

  abstractNote = {The present invention provides for novel peptoid oligomers that are capable of self-assembling into two-dimensional sheet structures. The peptoid oligomers can have alternately hydrophilic or polar side-chains and hydrophobic or apolar side-chains. The peptoid oligomers, and the two-dimensional sheet structures, can be applied to biological applications where the peptoid plays a role as a biological scaffold or building block. Also, the two-dimensional sheet structures of the present invention can be used as two-dimensional nanostructures in device applications.},

  doi          = {},

  journal      = {},
number       = ,

  volume       = ,

  place        = {United States},

  year         = {Tue Jul 07 00:00:00 EDT 2015},

  month        = {Tue Jul 07 00:00:00 EDT 2015}

}

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Works referenced in this record:

Synthesis of N-substituted oligomers
patent, March 1999

Zuckermann, Ronald N.; Goff, Dane; Ng, Simon
US Patent Document 5,877,278
URL: https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/5877278

Chimeric antisense oligonucleotides and cell transfecting formulations thereof
patent, January 2004

Innis, Michael A.; Reinhard, Christoph; Zuckermann, Ronald N.
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Biological sample component purification and differential display
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Zuckermann, Ronald N.; Beausoleil, Eric; Wachowicz, Matthew
US Patent Document 6,783,929
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Polypeptoid pulmonary surfactants
patent, May 2005

Barron, Annelise E.; Zuckermann, Ronald N.; Wu, Cindy W.
US Patent Document 6,887,845
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Fluorogenic dyes
patent, April 2006

Suich, Daniel J.; Zuckermann, Ronald N.
US Patent Document 7,026,166
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Peptoids incorporating chemoselective functionalities
patent, April 2006

Horn, Thomas; Zuckermann, Ronald N.
US Patent Document 7,030,216
URL: https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/7030216

Microarrays on mirrored substrates for performing proteomic analyses
patent, December 2006

Charych, Deborah H.; Beausoleil, Eric; Zuckermann, Ronald N.
US Patent Document 7,153,682
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Peptoids incorporating chemoselective functionalities
patent, August 2008

Horn, Thomas; Zuckermann, Ronald N.
US Patent Document 7,408,023
URL: https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/7408023

Oligonucleotide transfection screening method
patent, September 2008

Zuckermann, Ronald N.; Reinhard, Christoph; Jefferson, Anne
US Patent Document 7,422,861
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Prion-specific peptoid reagents
patent, November 2010

Peretz, David; Connolly, Michael; Zuckermann, Ronald N.
US Patent Document 7,834,144
URL: https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/7834144

Polypeptoid pulmonary surfactants
patent, February 2012

Barron, Annelise E.; Zuckermann, Ronald N.; Wu, Cindy W.
US Patent Document 8,114,830
URL: https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/8114830

Polypeptoid pulmonary surfactants
patent, March 2014

Barron, Annelise E.; Zuckermann, Ronald N.; Wu, Cindy W.
US Patent Document 8,673,842
URL: https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/8673842

Cell transfecting formulations of small interfering RNA related compositions and methods of making and use
patent, July 2014

Burkoth, Timothy S.; Jefferson, Anne; Reinhard, Christoph
US Patent Document 8,772,255
URL: https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/8772255

Prion-specific peptoid reagents
patent-application, April 2007

Peretz, David; Connolly, Michael; Zuckermann, Ronald
US Patent Application 11/518091; 20070087972
URL: https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20070087972

Optical imaging of endometriosis
patent-application, May 2007

Klaveness, Jo; Johannesen, Edvin; Tolleshaug, Helge
US Patent Application 10/573604; 20070116646
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Peptoids: a modular approach to drug discovery.
journal, October 1992

Simon, R. J.; Kania, R. S.; Zuckermann, R. N.
Proceedings of the National Academy of Sciences, Vol. 89, Issue 20
https://doi.org/10.1073/pnas.89.20.9367

NMR determination of the major solution conformation of a peptoid pentamer with chiral side chains
journal, April 1998

Armand, P.; Kirshenbaum, K.; Goldsmith, R. A.
Proceedings of the National Academy of Sciences, Vol. 95, Issue 8
https://doi.org/10.1073/pnas.95.8.4309

Peptoid Oligomers with α-Chiral, Aromatic Side Chains: Sequence Requirements for the Formation of Stable Peptoid Helices
journal, July 2001

Wu, Cindy W.; Sanborn, Tracy J.; Huang, Kai
Journal of the American Chemical Society, Vol. 123, Issue 28
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Peptoid Oligomers with α-Chiral, Aromatic Side Chains: Effects of Chain Length on Secondary Structure
journal, April 2001

Wu, Cindy W.; Sanborn, Tracy J.; Zuckermann, Ronald N.
Journal of the American Chemical Society, Vol. 123, Issue 13
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Extreme stability of helices formed by water-soluble poly-N-substituted glycines (polypeptoids) with ?-chiral side chains
journal, December 2001

Sanborn, Tracy J.; Wu, Cindy W.; Zuckermann, Ronald N.
Biopolymers, Vol. 63, Issue 1
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Folding a Nonbiological Polymer into a Compact Multihelical Structure
journal, August 2005

Lee, Byoung-Chul; Zuckermann, Ronald N.; Dill, Ken A.
Journal of the American Chemical Society, Vol. 127, Issue 31
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Biomimetic Nanostructures: Creating a High-Affinity Zinc-Binding Site in a Folded Nonbiological Polymer
journal, July 2008

Lee, Byoung-Chul; Chu, Tammy K.; Dill, Ken A.
Journal of the American Chemical Society, Vol. 130, Issue 27
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[25] Synthesis of N-substituted glycine peptoid libraries
book, January 1996

Figliozzi, Gianine M.; Goldsmith, Richard; Ng, Simon C.
Combinatorial Chemistry
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Alexa Dyes, a Series of New Fluorescent Dyes that Yield Exceptionally Bright, Photostable Conjugates
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Panchuk-Voloshina, Nataliya; Haugland, Rosaria P.; Bishop-Stewart, Janell
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The design, synthesis, and evaluation of molecules that enable or enhance cellular uptake: Peptoid molecular transporters
journal, November 2000

Wender, P. A.; Mitchell, D. J.; Pattabiraman, K.
Proceedings of the National Academy of Sciences, Vol. 97, Issue 24, p. 13003-13008
https://doi.org/10.1073/pnas.97.24.13003

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Similar Records

Title: Biomimetic peptoid polymers

Abstract

Citation Formats

Synthesis of N-substituted oligomers patent, March 1999

Chimeric antisense oligonucleotides and cell transfecting formulations thereof patent, January 2004

Biological sample component purification and differential display patent, August 2004

Polypeptoid pulmonary surfactants patent, May 2005

Fluorogenic dyes patent, April 2006

Peptoids incorporating chemoselective functionalities patent, April 2006

Microarrays on mirrored substrates for performing proteomic analyses patent, December 2006

Peptoids incorporating chemoselective functionalities patent, August 2008

Oligonucleotide transfection screening method patent, September 2008

Prion-specific peptoid reagents patent, November 2010

Polypeptoid pulmonary surfactants patent, February 2012

Polypeptoid pulmonary surfactants patent, March 2014

Cell transfecting formulations of small interfering RNA related compositions and methods of making and use patent, July 2014

Prion-specific peptoid reagents patent-application, April 2007

Optical imaging of endometriosis patent-application, May 2007

Peptoids: a modular approach to drug discovery. journal, October 1992

NMR determination of the major solution conformation of a peptoid pentamer with chiral side chains journal, April 1998

Peptoid Oligomers with α-Chiral, Aromatic Side Chains: Sequence Requirements for the Formation of Stable Peptoid Helices journal, July 2001

Peptoid Oligomers with α-Chiral, Aromatic Side Chains: Effects of Chain Length on Secondary Structure journal, April 2001

Extreme stability of helices formed by water-soluble poly-N-substituted glycines (polypeptoids) with ?-chiral side chains journal, December 2001

Folding a Nonbiological Polymer into a Compact Multihelical Structure journal, August 2005

Biomimetic Nanostructures: Creating a High-Affinity Zinc-Binding Site in a Folded Nonbiological Polymer journal, July 2008

[25] Synthesis of N-substituted glycine peptoid libraries book, January 1996

Alexa Dyes, a Series of New Fluorescent Dyes that Yield Exceptionally Bright, Photostable Conjugates journal, September 1999

The design, synthesis, and evaluation of molecules that enable or enhance cellular uptake: Peptoid molecular transporters journal, November 2000

Synthesis of N-substituted oligomers
patent, March 1999

Chimeric antisense oligonucleotides and cell transfecting formulations thereof
patent, January 2004

Biological sample component purification and differential display
patent, August 2004

Polypeptoid pulmonary surfactants
patent, May 2005

Fluorogenic dyes
patent, April 2006

Peptoids incorporating chemoselective functionalities
patent, April 2006

Microarrays on mirrored substrates for performing proteomic analyses
patent, December 2006

Peptoids incorporating chemoselective functionalities
patent, August 2008

Oligonucleotide transfection screening method
patent, September 2008

Prion-specific peptoid reagents
patent, November 2010

Polypeptoid pulmonary surfactants
patent, February 2012

Polypeptoid pulmonary surfactants
patent, March 2014

Cell transfecting formulations of small interfering RNA related compositions and methods of making and use
patent, July 2014

Prion-specific peptoid reagents
patent-application, April 2007

Optical imaging of endometriosis
patent-application, May 2007

Peptoids: a modular approach to drug discovery.
journal, October 1992

NMR determination of the major solution conformation of a peptoid pentamer with chiral side chains
journal, April 1998

Peptoid Oligomers with α-Chiral, Aromatic Side Chains: Sequence Requirements for the Formation of Stable Peptoid Helices
journal, July 2001

Peptoid Oligomers with α-Chiral, Aromatic Side Chains: Effects of Chain Length on Secondary Structure
journal, April 2001

Extreme stability of helices formed by water-soluble poly-N-substituted glycines (polypeptoids) with ?-chiral side chains
journal, December 2001

Folding a Nonbiological Polymer into a Compact Multihelical Structure
journal, August 2005

Biomimetic Nanostructures: Creating a High-Affinity Zinc-Binding Site in a Folded Nonbiological Polymer
journal, July 2008

[25] Synthesis of N-substituted glycine peptoid libraries
book, January 1996

Alexa Dyes, a Series of New Fluorescent Dyes that Yield Exceptionally Bright, Photostable Conjugates
journal, September 1999

The design, synthesis, and evaluation of molecules that enable or enhance cellular uptake: Peptoid molecular transporters
journal, November 2000