Method of treating depression

Henn, Fritz

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Title: Method of treating depression

Abstract

Methods for treatment of depression-related mood disorders in mammals, particularly humans are disclosed. The methods of the invention include administration of compounds capable of enhancing glutamate transporter activity in the brain of mammals suffering from depression. ATP-sensitive K.sup.+ channel openers and .beta.-lactam antibiotics are used to enhance glutamate transport and to treat depression-related mood disorders and depressive symptoms.

Inventors:

Henn, Fritz ^[1]

East Patchogue, NY

Issue Date:: Tue Jan 24 00:00:00 EST 2012

Research Org.:: Brookhaven Science Associates, LLC (Upton, NY)

Sponsoring Org.:: USDOE

OSTI Identifier:: 1034635

Patent Number(s):: 8101600

Application Number:: 12/641,968

Assignee:: Brookhaven Science Associates, LLC (Upton, NY)

Patent Classifications (CPCs):: A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61P - SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

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A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
A61K31/13 - Amines {
A61K31/44 - Non condensed pyridines
A61K31/54 - having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame

A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61P - SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
A61P25/24 - Antidepressants

C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07D - HETEROCYCLIC COMPOUNDS
C07D211/72 - with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
C07D285/22 - condensed with one six-membered ring

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DOE Contract Number:: AC02-98CH10886

Resource Type:: Patent

Country of Publication:: United States

Language:: English

Subject:: 60 APPLIED LIFE SCIENCES

Citation Formats


                    Henn, Fritz. Method of treating depression.  United States: N. p., 2012. 
        Web.

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                    Henn, Fritz. Method of treating depression.  United States.

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                    Henn, Fritz. Tue .  
        "Method of treating depression".  United States.  https://www.osti.gov/servlets/purl/1034635.

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@article{osti_1034635,

  title        = {Method of treating depression},

  author       = {Henn, Fritz},

  abstractNote = {Methods for treatment of depression-related mood disorders in mammals, particularly humans are disclosed. The methods of the invention include administration of compounds capable of enhancing glutamate transporter activity in the brain of mammals suffering from depression. ATP-sensitive K.sup.+ channel openers and .beta.-lactam antibiotics are used to enhance glutamate transport and to treat depression-related mood disorders and depressive symptoms.},

  doi          = {},

  journal      = {},
number       = ,

  volume       = ,

  place        = {United States},

  year         = {Tue Jan 24 00:00:00 EST 2012},

  month        = {Tue Jan 24 00:00:00 EST 2012}

}

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Works referenced in this record:

Effect of potassium channel modulators in mouse forced swimming test
journal, April 1999

Galeotti, Nicoletta; Ghelardini, Carla; Caldari, Bernardetta
British Journal of Pharmacology, Vol. 126, Issue 7
https://doi.org/10.1038/sj.bjp.0702467

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Title: Method of treating depression

Abstract

Citation Formats

Effect of potassium channel modulators in mouse forced swimming test journal, April 1999

Effect of potassium channel modulators in mouse forced swimming test
journal, April 1999