Methods for assisting recovery of damaged brain and spinal cord and treating various diseases using arrays of x-ray microplanar beams
Abstract
A method of assisting recovery of an injury site of the central nervous system (CNS) or treating a disease includes providing a therapeutic dose of X-ray radiation to a target volume through an array of parallel microplanar beams. The dose to treat CNS injury temporarily removes regeneration inhibitors from the irradiated site. Substantially unirradiated cells surviving between beams migrate to the in-beam portion and assist recovery. The dose may be staggered in fractions over sessions using angle-variable intersecting microbeam arrays (AVIMA). Additional doses are administered by varying the orientation of the beams. The method is enhanced by injecting stem cells into the injury site. One array or the AVIMA method is applied to ablate selected cells in a target volume associated with disease for palliative or curative effect. Atrial fibrillation is treated by irradiating the atrial wall to destroy myocardial cells while continuously rotating the subject.
- Inventors:
-
- Yaphank, NY
- Rocky Point, NY
- Holden, MA
- Monteroduni, IT
- Shoreham, NY
- Issue Date:
- Research Org.:
- Brookhaven National Laboratory (BNL), Upton, NY (United States)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 985214
- Patent Number(s):
- 7746979
- Application Number:
- 11/884,158
- Assignee:
- The United States of America as represented by the United States Department of Energy (Washington, DC)
- Patent Classifications (CPCs):
-
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61N - ELECTROTHERAPY
- DOE Contract Number:
- AC02-98CH10886
- Resource Type:
- Patent
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 62 RADIOLOGY AND NUCLEAR MEDICINE
Citation Formats
Dilmanian, F Avraham, Anchel, David J, Gaudette, Glenn, Romanelli, Pantaleo, and Hainfeld, James. Methods for assisting recovery of damaged brain and spinal cord and treating various diseases using arrays of x-ray microplanar beams. United States: N. p., 2010.
Web.
Dilmanian, F Avraham, Anchel, David J, Gaudette, Glenn, Romanelli, Pantaleo, & Hainfeld, James. Methods for assisting recovery of damaged brain and spinal cord and treating various diseases using arrays of x-ray microplanar beams. United States.
Dilmanian, F Avraham, Anchel, David J, Gaudette, Glenn, Romanelli, Pantaleo, and Hainfeld, James. Tue .
"Methods for assisting recovery of damaged brain and spinal cord and treating various diseases using arrays of x-ray microplanar beams". United States. https://www.osti.gov/servlets/purl/985214.
@article{osti_985214,
title = {Methods for assisting recovery of damaged brain and spinal cord and treating various diseases using arrays of x-ray microplanar beams},
author = {Dilmanian, F Avraham and Anchel, David J and Gaudette, Glenn and Romanelli, Pantaleo and Hainfeld, James},
abstractNote = {A method of assisting recovery of an injury site of the central nervous system (CNS) or treating a disease includes providing a therapeutic dose of X-ray radiation to a target volume through an array of parallel microplanar beams. The dose to treat CNS injury temporarily removes regeneration inhibitors from the irradiated site. Substantially unirradiated cells surviving between beams migrate to the in-beam portion and assist recovery. The dose may be staggered in fractions over sessions using angle-variable intersecting microbeam arrays (AVIMA). Additional doses are administered by varying the orientation of the beams. The method is enhanced by injecting stem cells into the injury site. One array or the AVIMA method is applied to ablate selected cells in a target volume associated with disease for palliative or curative effect. Atrial fibrillation is treated by irradiating the atrial wall to destroy myocardial cells while continuously rotating the subject.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Tue Jun 29 00:00:00 EDT 2010},
month = {Tue Jun 29 00:00:00 EDT 2010}
}
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