Global to push GA events into
skip to main content

Title: Methods of treating Parkinson's disease using viral vectors

Methods of delivering viral vectors, particularly recombinant adeno-associated virus (rAAV) virions, to the central nervous system (CNS) using convection enhanced delivery (CED) are provided. The rAAV virions include a nucleic acid sequence encoding a therapeutic polypeptide. The methods can be used for treating CNS disorders such as for treating Parkinson's Disease.
Inventors:
;
Issue Date:
OSTI Identifier:
1332285
Assignee:
The Regents of the University of California (Oakland, CA) LBNL
Patent Number(s):
9,492,415
Application Number:
13/647,155
Contract Number:
AC03-76SF00098; AC02-05CH11231
Resource Relation:
Patent File Date: 2012 Oct 08
Research Org:
Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)
Sponsoring Org:
USDOE
Country of Publication:
United States
Language:
English
Subject:
60 APPLIED LIFE SCIENCES; 59 BASIC BIOLOGICAL SCIENCES

Works referenced in this record:

Application of Gene Therapy for Parkinson's Disease: Nonhuman Primate Experience
book, January 1997

Adeno-associated virus vectors
journal, October 1992

A novel MPTP primate model of Parkinson's disease: neurochemical and clinical changes
journal, September 1998

Mechanism of MPTP toxicity: more answers, more questions
journal, January 1985

Effect of ischemic cerebral volume changes on behavior
journal, August 1997

Viral Gene Delivery Selectively Restores Feeding and Prevents Lethality of Dopamine-Deficient Mice
journal, January 1999