Methods of treating Parkinson's disease using viral vectors

Bankiewicz, Krystof; Cunningham, Janet

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Title: Methods of treating Parkinson's disease using viral vectors

Abstract

Methods of delivering viral vectors, particularly recombinant adeno-associated virus (rAAV) virions, to the central nervous system (CNS) using convection enhanced delivery (CED) are provided. The rAAV virions include a nucleic acid sequence encoding a therapeutic polypeptide. The methods can be used for treating CNS disorders such as for treating Parkinson's Disease.

Inventors:: Bankiewicz, Krystof; Cunningham, Janet

Issue Date:: 2016-11-15

Research Org.:: Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)

Sponsoring Org.:: USDOE

OSTI Identifier:: 1332285

Patent Number(s):: 9492415

Application Number:: 13/647,155

Assignee:: The Regents of the University of California (Oakland, CA)

Patent Classifications (CPCs):: A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61P - SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

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A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
A61K31/198 - Alpha-aminoacids, e.g. alanine, edetic acids [EDTA],
A61K35/761 - Adenovirus
A61K38/45 - Transferases
A61K38/51 - Lyases
A61K45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
A61K47/6901 - {Conjugates being cells, cell fragments, viruses, ghosts, red blood cells or viral vectors}
A61K48/00 - Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases
A61K48/0025 - {wherein the non-active part clearly interacts with the delivered nucleic acid}
A61K48/0075 - {characterised by an aspect of the delivery route, e.g. oral, subcutaneous}
A61K51/00 - Preparations containing radioactive substances for use in therapy or testing in vivo
A61K51/0402 - {carboxylic acid carriers, fatty acids
A61K9/5184 - {Virus capsids or envelopes enclosing drugs

A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61P - SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
A61P25/16 - Anti-Parkinson drugs

C - CHEMISTRY C12 - BIOCHEMISTRY C12N - MICROORGANISMS OR ENZYMES
C12N15/63 - Introduction of foreign genetic material using vectors
C12N15/86 - Viral vectors
C12N2750/14142 - virus or viral particle as vehicle, e.g. encapsulating small organic molecule
C12N2750/14143 - viral genome or elements thereof as genetic vector
C12N7/00 - Viruses

C - CHEMISTRY C12 - BIOCHEMISTRY C12Y - ENZYMES
C12Y401/01028 - Aromatic-L-amino-acid decarboxylase

Show less

DOE Contract Number:: AC03-76SF00098; AC02-05CH11231

Resource Type:: Patent

Resource Relation:: Patent File Date: 2012 Oct 08

Country of Publication:: United States

Language:: English

Subject:: 60 APPLIED LIFE SCIENCES; 59 BASIC BIOLOGICAL SCIENCES

Citation Formats


                    Bankiewicz, Krystof, and Cunningham, Janet. Methods of treating Parkinson's disease using viral vectors.  United States: N. p., 2016. 
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                    Bankiewicz, Krystof, & Cunningham, Janet. Methods of treating Parkinson's disease using viral vectors.  United States.

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                    Bankiewicz, Krystof, and Cunningham, Janet. Tue .  
        "Methods of treating Parkinson's disease using viral vectors".  United States.  https://www.osti.gov/servlets/purl/1332285.

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@article{osti_1332285,

  title        = {Methods of treating Parkinson's disease using viral vectors},

  author       = {Bankiewicz, Krystof and Cunningham, Janet},

  abstractNote = {Methods of delivering viral vectors, particularly recombinant adeno-associated virus (rAAV) virions, to the central nervous system (CNS) using convection enhanced delivery (CED) are provided. The rAAV virions include a nucleic acid sequence encoding a therapeutic polypeptide. The methods can be used for treating CNS disorders such as for treating Parkinson's Disease.},

  doi          = {},

  journal      = {},
number       = ,

  volume       = ,

  place        = {United States},

  year         = {2016},

  month        = {11}

}

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Similar Records

Title: Methods of treating Parkinson's disease using viral vectors

Abstract

Citation Formats

Method of treating parkinson's syndrome patent, April 1990

AAV transduction vectors patent, August 1992

Production of recombinant adeno-associated virus vectors patent, December 1992

Gene therapy patent, March 1995

Ribozymes targeted to apo(a) mRNA patent, February 1997

In vitro packaging of adeno-associated virus DNA patent, October 1997

Convection-enhanced drug delivery patent, February 1998

Method for production of neuroblasts patent, April 2000

Genetically engineered cells that produce produce L. Dopa patent, August 2000

AAV-mediated delivery of DNA to cells of the nervous system patent, January 2001

AAV-mediated delivery of DNA to cells of the nervous system patent, January 2003

Methods of treating central nervous system disorders using viral vectors patent, October 2005

Practical Aspects of the Development ofex Vivoandin VivoGene Therapy for Parkinson's Disease journal, March 1997

Application of Gene Therapy for Parkinson's Disease: Nonhuman Primate Experience book, January 1997

Adeno-associated virus vectors journal, October 1992

Ligand-targeted receptor-mediated vectors for gene delivery journal, January 1998

A novel MPTP primate model of Parkinson's disease: neurochemical and clinical changes journal, September 1998

Total synthesis of a human leukocyte interferon gene journal, August 1981

Prospects and problems of gene therapy: an update journal, October 2001

Characteristics of a Human Cell Line Transformed by DNA from Human Adenovirus Type 5 journal, July 1977

Convection-Enhanced Delivery of Adeno-Associated Virus Type 2 (AAV2) into the Striatum and Transport of AAV2 Within Monkey Brain journal, March 2006

Long-term correction of canine hemophilia B by gene transfer of blood coagulation factor IX mediated by adeno-associated viral vector journal, January 1999

Prospects for the Use of Adeno-Associated Virus as a Vector for Human Gene Therapy journal, July 1994

Mechanism of MPTP toxicity: more answers, more questions journal, January 1985

Long-term restoration of striatal l-aromatic amino acid decarboxylase activity using recombinant adeno-associated viral vector gene transfer in a rodent model of Parkinson's disease journal, August 1999

Effect of ischemic cerebral volume changes on behavior journal, August 1997

l-Dopa and Dopamine-Producing Gene Cassettes for Gene Therapy Approaches to Parkinson's Disease journal, March 1997

Gene Therapy in the United States: A Five-Year Status Report journal, September 1996

Viral Gene Delivery Selectively Restores Feeding and Prevents Lethality of Dopamine-Deficient Mice journal, January 1999

Gene therapy - promises, problems and prospects journal, September 1997

Adeno-associated virus vector-mediated transduction in the cat brain journal, September 2003

Gene Transfer by Adeno-Associated Virus Vectors into the Central Nervous System journal, March 1997

Method of treating parkinson's syndrome
patent, April 1990

AAV transduction vectors
patent, August 1992

Production of recombinant adeno-associated virus vectors
patent, December 1992

Gene therapy
patent, March 1995

Ribozymes targeted to apo(a) mRNA
patent, February 1997

In vitro packaging of adeno-associated virus DNA
patent, October 1997

Convection-enhanced drug delivery
patent, February 1998

Method for production of neuroblasts
patent, April 2000

Genetically engineered cells that produce produce L. Dopa
patent, August 2000

AAV-mediated delivery of DNA to cells of the nervous system
patent, January 2001

AAV-mediated delivery of DNA to cells of the nervous system
patent, January 2003

Methods of treating central nervous system disorders using viral vectors
patent, October 2005

Practical Aspects of the Development ofex Vivoandin VivoGene Therapy for Parkinson's Disease
journal, March 1997

Application of Gene Therapy for Parkinson's Disease: Nonhuman Primate Experience
book, January 1997

Adeno-associated virus vectors
journal, October 1992

Ligand-targeted receptor-mediated vectors for gene delivery
journal, January 1998

A novel MPTP primate model of Parkinson's disease: neurochemical and clinical changes
journal, September 1998

Total synthesis of a human leukocyte interferon gene
journal, August 1981

Prospects and problems of gene therapy: an update
journal, October 2001

Characteristics of a Human Cell Line Transformed by DNA from Human Adenovirus Type 5
journal, July 1977

Convection-Enhanced Delivery of Adeno-Associated Virus Type 2 (AAV2) into the Striatum and Transport of AAV2 Within Monkey Brain
journal, March 2006

Long-term correction of canine hemophilia B by gene transfer of blood coagulation factor IX mediated by adeno-associated viral vector
journal, January 1999

Prospects for the Use of Adeno-Associated Virus as a Vector for Human Gene Therapy
journal, July 1994

Mechanism of MPTP toxicity: more answers, more questions
journal, January 1985

Long-term restoration of striatal l-aromatic amino acid decarboxylase activity using recombinant adeno-associated viral vector gene transfer in a rodent model of Parkinson's disease
journal, August 1999

Effect of ischemic cerebral volume changes on behavior
journal, August 1997

l-Dopa and Dopamine-Producing Gene Cassettes for Gene Therapy Approaches to Parkinson's Disease
journal, March 1997

Gene Therapy in the United States: A Five-Year Status Report
journal, September 1996

Viral Gene Delivery Selectively Restores Feeding and Prevents Lethality of Dopamine-Deficient Mice
journal, January 1999

Gene therapy - promises, problems and prospects
journal, September 1997

Adeno-associated virus vector-mediated transduction in the cat brain
journal, September 2003

Gene Transfer by Adeno-Associated Virus Vectors into the Central Nervous System
journal, March 1997