Waveguides for performing enzymatic reactions
Abstract
The present invention is directed to a method and an apparatus for analysis of an analyte. The method involves providing a zero-mode waveguide which includes a cladding surrounding a core where the cladding is configured to preclude propagation of electromagnetic energy of a frequency less than a cutoff frequency longitudinally through the core of the zero-mode waveguide. The analyte is positioned in the core of the zero-mode waveguide and is then subjected, in the core of the zero-mode wave guide, to activating electromagnetic radiation of a frequency less than the cut-off frequency under conditions effective to permit analysis of the analyte in an effective observation volume which is more compact than if the analysis were carried out in the absence of the zero-mode waveguide.
- Inventors:
-
- Ithaca, NY
- Issue Date:
- Research Org.:
- Cornell Univ., Ithaca, NY (United States)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 919405
- Patent Number(s):
- 7292742
- Assignee:
- Cornell Research Foundation, Inc. (Ithaca, NY)
- Patent Classifications (CPCs):
-
B - PERFORMING OPERATIONS B82 - NANOTECHNOLOGY B82Y - SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES
C - CHEMISTRY C12 - BIOCHEMISTRY C12Q - MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
- Resource Type:
- Patent
- Country of Publication:
- United States
- Language:
- English
Citation Formats
Levene, Michael J., Korlach, Jonas, Turner, Stephen W., Craighead, Harold G., and Webb, Watt W.. Waveguides for performing enzymatic reactions. United States: N. p., 2007.
Web.
Levene, Michael J., Korlach, Jonas, Turner, Stephen W., Craighead, Harold G., & Webb, Watt W.. Waveguides for performing enzymatic reactions. United States.
Levene, Michael J., Korlach, Jonas, Turner, Stephen W., Craighead, Harold G., and Webb, Watt W.. Tue .
"Waveguides for performing enzymatic reactions". United States. https://www.osti.gov/servlets/purl/919405.
@article{osti_919405,
title = {Waveguides for performing enzymatic reactions},
author = {Levene, Michael J. and Korlach, Jonas and Turner, Stephen W. and Craighead, Harold G. and Webb, Watt W.},
abstractNote = {The present invention is directed to a method and an apparatus for analysis of an analyte. The method involves providing a zero-mode waveguide which includes a cladding surrounding a core where the cladding is configured to preclude propagation of electromagnetic energy of a frequency less than a cutoff frequency longitudinally through the core of the zero-mode waveguide. The analyte is positioned in the core of the zero-mode waveguide and is then subjected, in the core of the zero-mode wave guide, to activating electromagnetic radiation of a frequency less than the cut-off frequency under conditions effective to permit analysis of the analyte in an effective observation volume which is more compact than if the analysis were carried out in the absence of the zero-mode waveguide.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2007},
month = {11}
}
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