Agents for replacement of NAD+/NADH system in enzymatic reactions

Fish, Richard H.; Kerr, John B.; Lo, Christine H.

Title: Agents for replacement of NAD+/NADH system in enzymatic reactions

Patent · Tue Apr 06 00:00:00 EDT 2004

OSTI ID:1174800

Fish, Richard H.; Kerr, John B.; Lo, Christine H.

Novel agents acting as co-factors for replacement of NAD(P).sup.+ /NAD(P)H co-enzyme systems in enzymatic oxido-reductive reactions. Agents mimicking the action of NAD(P).sup.+ /NAD(P)H system in enzymatic oxidation/reduction of substrates into reduced or oxidized products. A method for selection and preparation of the mimicking agents for replacement of NAD(P).sup.+ /NAD(P)H system and a device comprising co-factors for replacement of NAD(P).sup.+ /NAD(P)H system.

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Research Organization:: Univ. of California, Oakland, CA (United States); Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)

Sponsoring Organization:: USDOE

DOE Contract Number:: AC03-76SF00098

Assignee:: University Of California, The Regents Of

Patent Number(s):: 6,716,596

Application Number:: 09/805,726

OSTI ID:: 1174800

Country of Publication:: United States

Language:: English

References (8)

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Bioorganometallic Chemistry. 13. Regioselective Reduction of NAD ⁺ Models, 1-Benzylnicotinamde Triflate and β-Nicotinamide Ribose-5‘-methyl Phosphate, with in Situ Generated [Cp*Rh(Bpy)H] ⁺ : Structure−Activity Relationships, Kinetics, and Mechanistic Aspects in the Formation of the 1,4-NADH Derivatives ^† Lo, H. Christine; Leiva, Carmen; Buriez, Olivier Inorganic Chemistry, Vol. 40, Issue 26 https://doi.org/10.1021/ic010562z	journal	December 2001
Identification of novel reduced pyridinium derivatives as synthetic co-factors for the enzyme DT diaphorase (NAD(P)H dehydrogenase (quinone), EC 1.6.99.2) Friedlos, Frank; Jarman, Michael; Davies, Lawrence C. Biochemical Pharmacology, Vol. 44, Issue 1 https://doi.org/10.1016/0006-2952(92)90033-F	journal	July 1992
Thermal and photochemical regeneration of nicotinamide cofactors and a nicotinamide model compound using a water-soluble rhodium phosphine catalyst Willner, Itamar; Maidan, Ruben; Shapira, Michal Journal of the Chemical Society, Perkin Transactions 2, Issue 4 https://doi.org/10.1039/p29900000559	journal	January 1990
Direct electron transfer from modified glassy carbon electrodes carrying covalently immobilised mediators to a dissolved viologen accepting pyridine nucleotide oxidoreductase and dihydrolipoamide dehydrogenase Paxinos, A. S.; Günther, H.; Schmedding, D. J. M. Bioelectrochemistry and Bioenergetics, Vol. 25, Issue 3 https://doi.org/10.1016/0302-4598(91)80007-P	journal	June 1991
Polymer-modified electrodes with pendant [RhIII(C5Me5)(L)Cl]+-complexes formed by γ-irradiation cross-linking Höfer, Eva; Steckhan, Eberhard; Ramos, Brigitte Journal of Electroanalytical Chemistry, Vol. 402, Issue 1-2 https://doi.org/10.1016/0022-0728(95)04243-1	journal	February 1996
Red-ox transformations of NAD+ model compounds Miller, Maria; Czochralska, Barbara; Shugar, David Bioelectrochemistry and Bioenergetics, Vol. 9, Issue 3 https://doi.org/10.1016/0302-4598(82)80018-4	journal	July 1982
Production of pyruvate from (R)-lactate in an enzyme–membrane reactor with coupled electrochemical regeneration of the artificial mediator anthraquinone-2,6-disulfonate Hekmat, Dariusch; Danninger, Johann; Simon, Helmut Enzyme and Microbial Technology, Vol. 24, Issue 8-9 https://doi.org/10.1016/S0141-0229(98)00135-5	journal	June 1999

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