skip to main content
DOE Patents title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Micro-machined calorimetric biosensors

Abstract

A method and apparatus are provided for detecting and monitoring micro-volumetric enthalpic changes caused by molecular reactions. Micro-machining techniques are used to create very small thermally isolated masses incorporating temperature-sensitive circuitry. The thermally isolated masses are provided with a molecular layer or coating, and the temperature-sensitive circuitry provides an indication when the molecules of the coating are involved in an enthalpic reaction. The thermally isolated masses may be provided singly or in arrays and, in the latter case, the molecular coatings may differ to provide qualitative and/or quantitative assays of a substance.

Inventors:
 [1];  [2];  [3];  [4];  [1];  [5];  [1];  [1]
  1. (Knoxville, TN)
  2. (Alcoa, TN)
  3. (Loudon, TN)
  4. (Plano, TX)
  5. (Powell, TN)
Issue Date:
Research Org.:
LOCKHEED MARTIN ENERGY RES COR
OSTI Identifier:
874661
Patent Number(s):
6436346
Assignee:
U T Battelle, LLC (Oak Ridge, TN) ORNL
DOE Contract Number:  
AC05-96OR22464
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
micro-machined; calorimetric; biosensors; method; apparatus; provided; detecting; monitoring; micro-volumetric; enthalpic; changes; caused; molecular; reactions; micro-machining; techniques; create; thermally; isolated; masses; incorporating; temperature-sensitive; circuitry; layer; coating; provides; indication; molecules; involved; reaction; singly; arrays; latter; coatings; provide; qualitative; andor; quantitative; assays; substance; thermally isolate; /422/73/374/436/438/

Citation Formats

Doktycz, Mitchel J., Britton, Jr., Charles L., Smith, Stephen F., Oden, Patrick I., Bryan, William L., Moore, James A., Thundat, Thomas G., and Warmack, Robert J. Micro-machined calorimetric biosensors. United States: N. p., 2002. Web.
Doktycz, Mitchel J., Britton, Jr., Charles L., Smith, Stephen F., Oden, Patrick I., Bryan, William L., Moore, James A., Thundat, Thomas G., & Warmack, Robert J. Micro-machined calorimetric biosensors. United States.
Doktycz, Mitchel J., Britton, Jr., Charles L., Smith, Stephen F., Oden, Patrick I., Bryan, William L., Moore, James A., Thundat, Thomas G., and Warmack, Robert J. Tue . "Micro-machined calorimetric biosensors". United States. https://www.osti.gov/servlets/purl/874661.
@article{osti_874661,
title = {Micro-machined calorimetric biosensors},
author = {Doktycz, Mitchel J. and Britton, Jr., Charles L. and Smith, Stephen F. and Oden, Patrick I. and Bryan, William L. and Moore, James A. and Thundat, Thomas G. and Warmack, Robert J.},
abstractNote = {A method and apparatus are provided for detecting and monitoring micro-volumetric enthalpic changes caused by molecular reactions. Micro-machining techniques are used to create very small thermally isolated masses incorporating temperature-sensitive circuitry. The thermally isolated masses are provided with a molecular layer or coating, and the temperature-sensitive circuitry provides an indication when the molecules of the coating are involved in an enthalpic reaction. The thermally isolated masses may be provided singly or in arrays and, in the latter case, the molecular coatings may differ to provide qualitative and/or quantitative assays of a substance.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2002},
month = {1}
}

Patent:

Save / Share: