Micro-machined calorimetric biosensors

Doktycz, Mitchel J; Smith, Stephen F; Oden, Patrick I; Bryan, William L; Moore, James A; Thundat, Thomas G; Warmack, Robert J

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Title: Micro-machined calorimetric biosensors

Abstract

A method and apparatus are provided for detecting and monitoring micro-volumetric enthalpic changes caused by molecular reactions. Micro-machining techniques are used to create very small thermally isolated masses incorporating temperature-sensitive circuitry. The thermally isolated masses are provided with a molecular layer or coating, and the temperature-sensitive circuitry provides an indication when the molecules of the coating are involved in an enthalpic reaction. The thermally isolated masses may be provided singly or in arrays and, in the latter case, the molecular coatings may differ to provide qualitative and/or quantitative assays of a substance.

Inventors:

Doktycz, Mitchel J ^[1]; Britton, Jr., Charles L. ^[2]; Smith, Stephen F ^[3]; Oden, Patrick I ^[4]; Bryan, William L ^[1]; Moore, James A ^[5]; Thundat, Thomas G ^[1]; Warmack, Robert J ^[1]

Knoxville, TN
(Alcoa, TN)
Loudon, TN
Plano, TX
Powell, TN

Issue Date:: Tue Jan 01 00:00:00 EST 2002

Research Org.:: Oak Ridge National Laboratory (ORNL), Oak Ridge, TN (United States)

OSTI Identifier:: 874661

Patent Number(s):: 6436346

Assignee:: U T Battelle, LLC (Oak Ridge, TN)

Patent Classifications (CPCs):: G - PHYSICS G01 - MEASURING G01K - MEASURING TEMPERATURE

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G - PHYSICS G01 - MEASURING G01K - MEASURING TEMPERATURE
G01K17/006 - {Microcalorimeters, e.g. using silicon microstructures}

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DOE Contract Number:: AC05-96OR22464

Resource Type:: Patent

Country of Publication:: United States

Language:: English

Subject:: micro-machined; calorimetric; biosensors; method; apparatus; provided; detecting; monitoring; micro-volumetric; enthalpic; changes; caused; molecular; reactions; micro-machining; techniques; create; thermally; isolated; masses; incorporating; temperature-sensitive; circuitry; layer; coating; provides; indication; molecules; involved; reaction; singly; arrays; latter; coatings; provide; qualitative; andor; quantitative; assays; substance; thermally isolate; /422/73/374/436/438/

Citation Formats


                    Doktycz, Mitchel J, Britton, Jr., Charles L., Smith, Stephen F, Oden, Patrick I, Bryan, William L, Moore, James A, Thundat, Thomas G, and Warmack, Robert J. Micro-machined calorimetric biosensors.  United States: N. p., 2002. 
        Web.

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                    Doktycz, Mitchel J, Britton, Jr., Charles L., Smith, Stephen F, Oden, Patrick I, Bryan, William L, Moore, James A, Thundat, Thomas G, & Warmack, Robert J. Micro-machined calorimetric biosensors.  United States.

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                    Doktycz, Mitchel J, Britton, Jr., Charles L., Smith, Stephen F, Oden, Patrick I, Bryan, William L, Moore, James A, Thundat, Thomas G, and Warmack, Robert J. Tue .  
        "Micro-machined calorimetric biosensors".  United States.  https://www.osti.gov/servlets/purl/874661.

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@article{osti_874661,

  title        = {Micro-machined calorimetric biosensors},

  author       = {Doktycz, Mitchel J and Britton, Jr., Charles L. and Smith, Stephen F and Oden, Patrick I and Bryan, William L and Moore, James A and Thundat, Thomas G and Warmack, Robert J},

  abstractNote = {A method and apparatus are provided for detecting and monitoring micro-volumetric enthalpic changes caused by molecular reactions. Micro-machining techniques are used to create very small thermally isolated masses incorporating temperature-sensitive circuitry. The thermally isolated masses are provided with a molecular layer or coating, and the temperature-sensitive circuitry provides an indication when the molecules of the coating are involved in an enthalpic reaction. The thermally isolated masses may be provided singly or in arrays and, in the latter case, the molecular coatings may differ to provide qualitative and/or quantitative assays of a substance.},

  doi          = {},

  journal      = {},
number       = ,

  volume       = ,

  place        = {United States},

  year         = {Tue Jan 01 00:00:00 EST 2002},

  month        = {Tue Jan 01 00:00:00 EST 2002}

}

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Works referenced in this record:

A vibrating probe thermal biochemical sensor
journal, January 1996

Towe, Bruce C.; Guilbeau, Eric J.
Biosensors and Bioelectronics, Vol. 11, Issue 3
https://doi.org/10.1016/0956-5663(96)88411-9

An integrated silicon thermopile as biosensor for the thermal monitoring of glucose, urea and penicillin
journal, January 1993

Bataillard, P.; Steffgen, E.; Haemmerli, S.
Biosensors and Bioelectronics, Vol. 8, Issue 2
https://doi.org/10.1016/0956-5663(93)80057-V

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Title: Micro-machined calorimetric biosensors

Abstract

Citation Formats

A vibrating probe thermal biochemical sensor journal, January 1996

An integrated silicon thermopile as biosensor for the thermal monitoring of glucose, urea and penicillin journal, January 1993

A vibrating probe thermal biochemical sensor
journal, January 1996

An integrated silicon thermopile as biosensor for the thermal monitoring of glucose, urea and penicillin
journal, January 1993