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Photoacoustic removal of occlusions from blood vessels

Patent ·
OSTI ID:874634
 [1];  [2];  [3];  [4];  [5]
  1. Livermore, CA
  2. Danville, CA
  3. Berkeley, CA
  4. Orinda, CA
  5. San Francisco, CA
+ Show Author Affiliations

Partial or total occlusions of fluid passages within the human body are removed by positioning an array of optical fibers in the passage and directing treatment radiation pulses along the fibers, one at a time, to generate a shock wave and hydrodynamics flows that strike and emulsify the occlusions. A preferred application is the removal of blood clots (thrombin and embolic) from small cerebral vessels to reverse the effects of an ischemic stroke. The operating parameters and techniques are chosen to minimize the amount of heating of the fragile cerebral vessel walls occurring during this photo acoustic treatment. One such technique is the optical monitoring of the existence of hydrodynamics flow generating vapor bubbles when they are expected to occur and stopping the heat generating pulses propagated along an optical fiber that is not generating such bubbles.

Research Organization:
Lawrence Livermore National Laboratory (LLNL), Livermore, CA
DOE Contract Number:
W-7405-ENG-48
Assignee:
The Regents of the University of California (Oakland, CA); Endovasix, Inc. (Belmont, CA)
Patent Number(s):
US 6428531
OSTI ID:
874634
Country of Publication:
United States
Language:
English

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