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Characterization of highly scattering media by measurement of diffusely backscattered polarized light

Patent ·
OSTI ID:872798
 [1];  [2];  [2]
  1. Brooklyn, NY
  2. Los Alamos, NM
+ Show Author Affiliations

An apparatus and method for recording spatially dependent intensity patterns of polarized light that is diffusely backscattered from highly scattering media are described. These intensity patterns can be used to differentiate different turbid media, such as polystyrene-sphere and biological-cell suspensions. Polarized light from a He-Ne laser (.lambda.=543 nm) is focused onto the surface of the scattering medium, and a surface area of approximately 4.times.4 cm centered on the light input point is imaged through polarization analysis optics onto a CCD camera. A variety of intensity patterns may be observed by varying the polarization state of the incident laser light and changing the analyzer configuration to detect different polarization components of the backscattered light. Experimental results for polystyrene-sphere and Intralipid suspensions demonstrate that the radial and azimuthal variations of the observed pattern depend on the concentration, size, and anisotropy factor, g, of the particles constituting the scattering medium. Measurements performed on biological cell suspensions show that intensity patterns can be used to differentiate between suspensions of cancerous and non-cancerous cells. Introduction of the Mueller-matrix for diffusely backscattered light, permits the selection of a subset of measurements which comprehensively describes the optical properties of backscattering media.

Research Organization:
Los Alamos National Laboratory (LANL), Los Alamos, NM
DOE Contract Number:
W-7405-ENG-36
Assignee:
Regents of University of California (Los Alamos, NM)
Patent Number(s):
US 6011626
OSTI ID:
872798
Country of Publication:
United States
Language:
English

References (13)

Polarized light transmission through skin using video reflectometry: toward optical tomography of superficial tissue layers conference May 1996
Time resolved depolarization of multiple backscattered light from random media journal December 1989
Diffuse backscattering Mueller matricesof highly scattering media journal January 1997
Video reflectometry to specify optical properties of tissue in vivo conference July 2017
Contribution of the mitochondrial compartment to the optical properties of the rat liver: a theoretical and practical approach journal December 1994
Photon pathlength distribution from polarized backscattering in random media journal August 1996
Stokes vectors, Mueller matrices, and polarized scattered light journal May 1985
Spatially resolved absolute diffuse reflectance measurements for noninvasive determination of the optical scattering and absorption coefficients of biological tissue journal January 1996
Polarized Light Examination and Photography of the Skin journal July 1991
Polarized light scattering from biological systems: A technique for cell differentiation journal June 1981
Influence of particle size and concentration on the diffuse backscattering of polarized light from tissue phantoms and biological cell suspensions journal January 1997
Application of polarization effects in light scattering: a new biophysical tool. journal February 1976
A diffusion theory model of spatially resolved, steady-state diffuse reflectance for the noninvasive determination of tissue optical properties in vivo journal July 1992

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