Title: Method of detoxifying animal suffering from overdose

Abstract

A method for accumulating drugs or other chemicals within synthetic, lipid-like vesicles by means of a pH gradient imposed on the vesicles just prior to use is described. The method is suited for accumulating molecules with basic or acid moieties which are permeable to the vesicles membranes in their uncharged form and for molecules that contain charge moieties that are hydrophobic ions and can therefore cross the vesicle membranes in their charged form. The method is advantageous over prior art methods for encapsulating biologically active materials within vesicles in that it achieves very high degrees of loading with simple procedures that are economical and require little technical expertise, furthermore kits which can be stored for prolonged periods prior to use without impairment of the capacity to achieve drug accumulation are described. A related application of the method consists of using this technology to detoxify animals that have been exposed to poisons with basic, weak acid or hydrophobic charge groups within their molecular structure.

Inventors:

Mehlhorn, Rolf J ^[1]

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1. Richmond, CA

Issue Date:

1997-01-01

Research Org.:

Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)

OSTI Identifier:

870908

Patent Number(s):

5622713

Assignee:

Regents of University of California (Alameda, CA)

Patent Classifications (CPCs):

A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

Y - NEW / CROSS SECTIONAL TECHNOLOGIES Y10 - TECHNICAL SUBJECTS COVERED BY FORMER USPC Y10T - TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION

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A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

A61K9/1278 - {Post-loading, e.g. by ion or pH gradient}

Y - NEW / CROSS SECTIONAL TECHNOLOGIES Y10 - TECHNICAL SUBJECTS COVERED BY FORMER USPC Y10T - TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION

Y10T428/2984 - Microcapsule with fluid core [includes liposome]

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DOE Contract Number:  

AC03-76SF00098

Resource Type:

Patent

Country of Publication:

United States

Language:

English

Subject:

method; detoxifying; animal; suffering; overdose; accumulating; drugs; chemicals; synthetic; lipid-like; vesicles; means; ph; gradient; imposed; prior; described; suited; molecules; basic; acid; moieties; permeable; membranes; uncharged; form; contain; charge; hydrophobic; vesicle; charged; advantageous; methods; encapsulating; biologically; active; materials; achieves; degrees; loading; simple; procedures; economical; require; technical; expertise; furthermore; kits; stored; prolonged; periods; impairment; capacity; achieve; drug; accumulation; related; application; consists; technology; detoxify; animals; exposed; poisons; weak; molecular; structure; method consists; biologically active; active material; active materials; weak acid; prolonged period; periods prior; molecular structure; prolonged periods; ph gradient; gradient imposed; accumulating drugs; lipid-like vesicles; /424/264/428/514/