Radiopharmaceutical composition containing tantalum-178 and process therefor
Abstract
A physiologically acceptable solution of tantalum-178 having an activity of 0.1 to 200 millicuries per milliliter of tantalum-178 solution is provided. The solution is obtained from tungsten-178 bound to a column of an anion exchange resin which forms tantalum-178 in situ by eluting the column with a hydrochloric acid solution containing hydrogen peroxide to form an acidic solution of tantalum-178. The acidic solution of tantalum-178 then is neutralized.
- Inventors:
-
- Medfield, MA
- Chestnut Hill, MA
- Westwood, MA
- East Lansing, MI
- Issue Date:
- Research Org.:
- Massachusetts Inst. of Technology (MIT), Cambridge, MA (United States)
- OSTI Identifier:
- 866963
- Patent Number(s):
- 4830848
- Application Number:
- 07/027,573
- Assignee:
- Massachusetts Institute of Technology (Cambridge, MA)
- Patent Classifications (CPCs):
-
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
- DOE Contract Number:
- AC02-76EV04115
- Resource Type:
- Patent
- Country of Publication:
- United States
- Language:
- English
- Subject:
- radiopharmaceutical; composition; containing; tantalum-178; process; physiologically; acceptable; solution; activity; 200; millicuries; milliliter; provided; obtained; tungsten-178; bound; column; anion; exchange; resin; forms; situ; eluting; hydrochloric; acid; hydrogen; peroxide; form; acidic; neutralized; containing hydrogen; hydrogen peroxide; hydrochloric acid; anion exchange; acid solution; solution containing; exchange resin; composition containing; acidic solution; radiopharmaceutical composition; pharmaceutical composition; acceptable solution; physiologically acceptable; /424/206/252/
Citation Formats
Neirinckx, Rudi D, Holman, B Leonard, Davis, Michael A, and Harris, Gale I. Radiopharmaceutical composition containing tantalum-178 and process therefor. United States: N. p., 1989.
Web.
Neirinckx, Rudi D, Holman, B Leonard, Davis, Michael A, & Harris, Gale I. Radiopharmaceutical composition containing tantalum-178 and process therefor. United States.
Neirinckx, Rudi D, Holman, B Leonard, Davis, Michael A, and Harris, Gale I. Tue .
"Radiopharmaceutical composition containing tantalum-178 and process therefor". United States. https://www.osti.gov/servlets/purl/866963.
@article{osti_866963,
title = {Radiopharmaceutical composition containing tantalum-178 and process therefor},
author = {Neirinckx, Rudi D and Holman, B Leonard and Davis, Michael A and Harris, Gale I},
abstractNote = {A physiologically acceptable solution of tantalum-178 having an activity of 0.1 to 200 millicuries per milliliter of tantalum-178 solution is provided. The solution is obtained from tungsten-178 bound to a column of an anion exchange resin which forms tantalum-178 in situ by eluting the column with a hydrochloric acid solution containing hydrogen peroxide to form an acidic solution of tantalum-178. The acidic solution of tantalum-178 then is neutralized.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Tue May 16 00:00:00 EDT 1989},
month = {Tue May 16 00:00:00 EDT 1989}
}