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Title: Radiopharmaceutical composition containing tantalum-178 and process therefor

Abstract

A physiologically acceptable solution of tantalum-178 having an activity of 0.1 to 200 millicuries per milliliter of tantalum-178 solution is provided. The solution is obtained from tungsten-178 bound to a column of an anion exchange resin which forms tantalum-178 in situ by eluting the column with a hydrochloric acid solution containing hydrogen peroxide to form an acidic solution of tantalum-178. The acidic solution of tantalum-178 then is neutralized.

Inventors:
 [1];  [2];  [3];  [4]
  1. Medfield, MA
  2. Chestnut Hill, MA
  3. Westwood, MA
  4. East Lansing, MI
Issue Date:
Research Org.:
Massachusetts Inst. of Technology (MIT), Cambridge, MA (United States)
OSTI Identifier:
866963
Patent Number(s):
4830848
Application Number:
07/027,573
Assignee:
Massachusetts Institute of Technology (Cambridge, MA)
Patent Classifications (CPCs):
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
DOE Contract Number:  
AC02-76EV04115
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
radiopharmaceutical; composition; containing; tantalum-178; process; physiologically; acceptable; solution; activity; 200; millicuries; milliliter; provided; obtained; tungsten-178; bound; column; anion; exchange; resin; forms; situ; eluting; hydrochloric; acid; hydrogen; peroxide; form; acidic; neutralized; containing hydrogen; hydrogen peroxide; hydrochloric acid; anion exchange; acid solution; solution containing; exchange resin; composition containing; acidic solution; radiopharmaceutical composition; pharmaceutical composition; acceptable solution; physiologically acceptable; /424/206/252/

Citation Formats

Neirinckx, Rudi D, Holman, B Leonard, Davis, Michael A, and Harris, Gale I. Radiopharmaceutical composition containing tantalum-178 and process therefor. United States: N. p., 1989. Web.
Neirinckx, Rudi D, Holman, B Leonard, Davis, Michael A, & Harris, Gale I. Radiopharmaceutical composition containing tantalum-178 and process therefor. United States.
Neirinckx, Rudi D, Holman, B Leonard, Davis, Michael A, and Harris, Gale I. Tue . "Radiopharmaceutical composition containing tantalum-178 and process therefor". United States. https://www.osti.gov/servlets/purl/866963.
@article{osti_866963,
title = {Radiopharmaceutical composition containing tantalum-178 and process therefor},
author = {Neirinckx, Rudi D and Holman, B Leonard and Davis, Michael A and Harris, Gale I},
abstractNote = {A physiologically acceptable solution of tantalum-178 having an activity of 0.1 to 200 millicuries per milliliter of tantalum-178 solution is provided. The solution is obtained from tungsten-178 bound to a column of an anion exchange resin which forms tantalum-178 in situ by eluting the column with a hydrochloric acid solution containing hydrogen peroxide to form an acidic solution of tantalum-178. The acidic solution of tantalum-178 then is neutralized.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {1989},
month = {5}
}