Monoclonal antibodies for the separate detection of halodeoxyuridines and method for their use
Abstract
Monoclonal antibodies are described which have specific affinities for halogenated nucleoside analogs and are preferentially selective for one particular halogen. Such antibodies, when incorporated into immunochemical reagents, may be used to identify and independently quantify the cell division character of more than one population or subpopulation in flow cytometric measurements. Independent assessment of division activity in cell sub-populations facilitates selection of appropriate time and dose for administration of anti-proliferative agents. The hybridomas which secrete halogen selective antibodies and the method of making them are described. 14 figures.
- Inventors:
- Issue Date:
- OSTI Identifier:
- 7082358
- Patent Number(s):
- 5053336
- Application Number:
- PPN: US 7-380638
- Assignee:
- University of California, Oakland, CA (United States)
- DOE Contract Number:
- W-7405-ENG-48
- Resource Type:
- Patent
- Resource Relation:
- Patent File Date: 17 Jul 1989
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 59 BASIC BIOLOGICAL SCIENCES; MONOCLONAL ANTIBODIES; SPECIFICITY; NUCLEOSIDES; AFFINITY; CELL FLOW SYSTEMS; IMMUNOLOGY; ANTIBODIES; NUCLEOTIDES; ORGANIC COMPOUNDS; RIBOSIDES; 550200* - Biochemistry
Citation Formats
Vanderlaan, M, Watkins, B E, and Stanker, L H. Monoclonal antibodies for the separate detection of halodeoxyuridines and method for their use. United States: N. p., 1991.
Web.
Vanderlaan, M, Watkins, B E, & Stanker, L H. Monoclonal antibodies for the separate detection of halodeoxyuridines and method for their use. United States.
Vanderlaan, M, Watkins, B E, and Stanker, L H. Tue .
"Monoclonal antibodies for the separate detection of halodeoxyuridines and method for their use". United States.
@article{osti_7082358,
title = {Monoclonal antibodies for the separate detection of halodeoxyuridines and method for their use},
author = {Vanderlaan, M and Watkins, B E and Stanker, L H},
abstractNote = {Monoclonal antibodies are described which have specific affinities for halogenated nucleoside analogs and are preferentially selective for one particular halogen. Such antibodies, when incorporated into immunochemical reagents, may be used to identify and independently quantify the cell division character of more than one population or subpopulation in flow cytometric measurements. Independent assessment of division activity in cell sub-populations facilitates selection of appropriate time and dose for administration of anti-proliferative agents. The hybridomas which secrete halogen selective antibodies and the method of making them are described. 14 figures.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Tue Oct 01 00:00:00 EDT 1991},
month = {Tue Oct 01 00:00:00 EDT 1991}
}
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