skip to main content
DOE Patents title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Monoclonal antibodies for the separate detection of halodeoxyuridines and method for their use

Abstract

Monoclonal antibodies are described which have specific affinities for halogenated nucleoside analogs and are preferentially selective for one particular halogen. Such antibodies, when incorporated into immunochemical reagents, may be used to identify and independently quantify the cell division character of more than one population or subpopulation in flow cytometric measurements. Independent assessment of division activity in cell sub-populations facilitates selection of appropriate time and dose for administration of anti-proliferative agents. The hybridomas which secrete halogen selective antibodies and the method of making them are described. 14 figures.

Inventors:
; ;
Issue Date:
OSTI Identifier:
7082358
Patent Number(s):
5053336
Application Number:
PPN: US 7-380638
Assignee:
University of California, Oakland, CA (United States)
DOE Contract Number:  
W-7405-ENG-48
Resource Type:
Patent
Resource Relation:
Patent File Date: 17 Jul 1989
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; MONOCLONAL ANTIBODIES; SPECIFICITY; NUCLEOSIDES; AFFINITY; CELL FLOW SYSTEMS; IMMUNOLOGY; ANTIBODIES; NUCLEOTIDES; ORGANIC COMPOUNDS; RIBOSIDES; 550200* - Biochemistry

Citation Formats

Vanderlaan, M, Watkins, B E, and Stanker, L H. Monoclonal antibodies for the separate detection of halodeoxyuridines and method for their use. United States: N. p., 1991. Web.
Vanderlaan, M, Watkins, B E, & Stanker, L H. Monoclonal antibodies for the separate detection of halodeoxyuridines and method for their use. United States.
Vanderlaan, M, Watkins, B E, and Stanker, L H. Tue . "Monoclonal antibodies for the separate detection of halodeoxyuridines and method for their use". United States.
@article{osti_7082358,
title = {Monoclonal antibodies for the separate detection of halodeoxyuridines and method for their use},
author = {Vanderlaan, M and Watkins, B E and Stanker, L H},
abstractNote = {Monoclonal antibodies are described which have specific affinities for halogenated nucleoside analogs and are preferentially selective for one particular halogen. Such antibodies, when incorporated into immunochemical reagents, may be used to identify and independently quantify the cell division character of more than one population or subpopulation in flow cytometric measurements. Independent assessment of division activity in cell sub-populations facilitates selection of appropriate time and dose for administration of anti-proliferative agents. The hybridomas which secrete halogen selective antibodies and the method of making them are described. 14 figures.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {1991},
month = {10}
}