Lipid composition for the delivery of therapeutic cargos
Abstract
A construct includes a core comprising an external surface and a plurality of pores, a cargo disposed in a pore of the plurality of pores, the cargo comprising a CRISPR Cas9 component or a nucleic acid sequence encoding a CRISPR Cas9 component; and a coating coupled to the core, wherein the coating comprises a cationic lipid, a pegylated lipid, a zwitterionic lipid, and a sterol. The coating may comprise a molar ratio of about 1 cationic lipid to 1 zwitterionic lipid to 0.9 sterol to 0.15 PEGylated lipid, wherein each molar ratio optionally varies by about plus or minus 10%. A method of treatment is also provided.
- Inventors:
- Issue Date:
- Research Org.:
- Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)
- Sponsoring Org.:
- USDOE National Nuclear Security Administration (NNSA)
- OSTI Identifier:
- 1925045
- Patent Number(s):
- 11433121
- Application Number:
- 16/839,194
- Assignee:
- National Technology & Engineering Solutions of Sandia, LLC (Albuquerque, NM)
- Patent Classifications (CPCs):
-
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
C - CHEMISTRY C12 - BIOCHEMISTRY C12N - MICROORGANISMS OR ENZYMES
- DOE Contract Number:
- NA0003525
- Resource Type:
- Patent
- Resource Relation:
- Patent File Date: 04/03/2020
- Country of Publication:
- United States
- Language:
- English
Citation Formats
Negrete, Oscar, LaBauve, Annette Estelle, Schoeniger, Joseph S., and Saada, Edwin A. Lipid composition for the delivery of therapeutic cargos. United States: N. p., 2022.
Web.
Negrete, Oscar, LaBauve, Annette Estelle, Schoeniger, Joseph S., & Saada, Edwin A. Lipid composition for the delivery of therapeutic cargos. United States.
Negrete, Oscar, LaBauve, Annette Estelle, Schoeniger, Joseph S., and Saada, Edwin A. Tue .
"Lipid composition for the delivery of therapeutic cargos". United States. https://www.osti.gov/servlets/purl/1925045.
@article{osti_1925045,
title = {Lipid composition for the delivery of therapeutic cargos},
author = {Negrete, Oscar and LaBauve, Annette Estelle and Schoeniger, Joseph S. and Saada, Edwin A.},
abstractNote = {A construct includes a core comprising an external surface and a plurality of pores, a cargo disposed in a pore of the plurality of pores, the cargo comprising a CRISPR Cas9 component or a nucleic acid sequence encoding a CRISPR Cas9 component; and a coating coupled to the core, wherein the coating comprises a cationic lipid, a pegylated lipid, a zwitterionic lipid, and a sterol. The coating may comprise a molar ratio of about 1 cationic lipid to 1 zwitterionic lipid to 0.9 sterol to 0.15 PEGylated lipid, wherein each molar ratio optionally varies by about plus or minus 10%. A method of treatment is also provided.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Tue Sep 06 00:00:00 EDT 2022},
month = {Tue Sep 06 00:00:00 EDT 2022}
}
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