Synthetic biochemistry molecular purge valve module that maintain co-factor balance
Abstract
The disclosure provides a metabolic pathway for producing a metabolite, the metabolic pathway having a co-factor purge valve system for recycling a cofactor used in the metabolic pathway.
- Inventors:
- Issue Date:
- Research Org.:
- Univ. of California, Oakland, CA (United States)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1771578
- Patent Number(s):
- 10822623
- Application Number:
- 16/243,332
- Assignee:
- The Regents of the University of California (Oakland, CA)
- Patent Classifications (CPCs):
-
C - CHEMISTRY C12 - BIOCHEMISTRY C12N - MICROORGANISMS OR ENZYMES
C - CHEMISTRY C12 - BIOCHEMISTRY C12P - FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE {
- DOE Contract Number:
- FC02-02ER63421
- Resource Type:
- Patent
- Resource Relation:
- Patent File Date: 01/09/2019
- Country of Publication:
- United States
- Language:
- English
Citation Formats
Bowie, James U., Opgenorth, Paul H., and Korman, Tyler P. Synthetic biochemistry molecular purge valve module that maintain co-factor balance. United States: N. p., 2020.
Web.
Bowie, James U., Opgenorth, Paul H., & Korman, Tyler P. Synthetic biochemistry molecular purge valve module that maintain co-factor balance. United States.
Bowie, James U., Opgenorth, Paul H., and Korman, Tyler P. Tue .
"Synthetic biochemistry molecular purge valve module that maintain co-factor balance". United States. https://www.osti.gov/servlets/purl/1771578.
@article{osti_1771578,
title = {Synthetic biochemistry molecular purge valve module that maintain co-factor balance},
author = {Bowie, James U. and Opgenorth, Paul H. and Korman, Tyler P.},
abstractNote = {The disclosure provides a metabolic pathway for producing a metabolite, the metabolic pathway having a co-factor purge valve system for recycling a cofactor used in the metabolic pathway.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Tue Nov 03 00:00:00 EST 2020},
month = {Tue Nov 03 00:00:00 EST 2020}
}
Save to My Library
You must Sign In or Create an Account in order to save documents to your library.
Works referenced in this record:
Cofactor engineering in Saccharomyces cerevisiae: Expression of a H2O-forming NADH oxidase and impact on redox metabolism
journal, July 2006
- Heux, Stéphanie; Cachon, Rémy; Dequin, Sylvie
- Metabolic Engineering, Vol. 8, Issue 4
Metabolic Engineering of Escherichia coli: Increase of NADH Availability by Overexpressing an NAD+-Dependent Formate Dehydrogenase
journal, July 2002
- Berríos-Rivera, Susana; Bennett, George N.; San, Ka-Yiu
- Metabolic Engineering, Vol. 4, Issue 3, p. 217-229
A synthetic biochemistry molecular purge valve module that maintains redox balance
journal, June 2014
- Opgenorth, Paul H.; Korman, Tyler P.; Bowie, James U.
- Nature Communications, Vol. 5, Issue 1
A synthetic biochemistry module for production of bio-based chemicals from glucose
journal, April 2016
- Opgenorth, Paul H.; Korman, Tyler P.; Bowie, James U.
- Nature Chemical Biology, Vol. 12, Issue 6
Synthetic biochemistry molecular purge valve module that maintain co-factor balance
patent, February 2019
- Bowie, James U.; Opgenorth, Paul H.; Korman, Tyler P.
- US Patent Document 10,196,653
A synthetic biochemistry system for the in vitro production of isoprene from glycolysis intermediates : Production of Isoprene from Glycolysis Intermediates
journal, March 2014
- Korman, Tyler P.; Sahachartsiri, Bobby; Li, Dan
- Protein Science, Vol. 23, Issue 5
Microorganisms and Methods for Enhancing the Availability of Reducing Equivalents in the Presence of Methanol, and for Producing 1,4-Butanediol Related Thereto
patent-application, February 2014
- Burgard, Anthony P.; Osterhout, Robin E.; Van Dien, Stephen J.
- US Patent Application 13/975678; 20140058056
Process for the Enzymatic Regeneration of Redox Cofactors
patent-application, December 2014
- Ertl, Ortwin; Staunig, Nicole; Sut, Marta
- US Patent Application 14/376512; 20140377798
A synthetic biochemistry platform for cell free production of monoterpenes from glucose
journal, May 2017
- Korman, Tyler P.; Opgenorth, Paul H.; Bowie, James U.
- Nature Communications, Vol. 8, Issue 1
Redox driven metabolic tuning: Carbon source and aeration affect synthesis of poly(3-hydroxybutyrate) in Escherichia coli
journal, July 2010
- Nikel, Pablo I.; de Almeida, Alejandra; Giordano, Andrea M.
- Bioengineered Bugs, Vol. 1, Issue 4
A molecular rheostat maintains ATP levels to drive a synthetic biochemistry system
journal, July 2017
- Opgenorth, Paul H.; Korman, Tyler P.; Iancu, Liviu
- Nature Chemical Biology, Vol. 13, Issue 9
Enzyme-catalyzed poly(3-hydroxybutyrate) synthesis from acetate with CoA recycling and NADPH regeneration in Vitro
journal, January 2003
- Satoh, Yasuharu; Tajima, Kenji; Tannai, Hatsumi
- Journal of Bioscience and Bioengineering, Vol. 95, Issue 4